CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Regulation of the homeodomain transcription factor WUSCHEL concentration is critical for stem cell homeostasis in Arabidopsis shoot apical meristems. WUSCHEL regulates the transcription of CLAVATA3 through a concentration-dependent activation-repression switch. CLAVATA3, a secreted peptide, activates receptor kinase signaling to repress WUSCHEL transcription. Considering the revised regulation, CLAVATA3 mediated repression of WUSCHEL transcription alone will lead to an unstable system. Here we show that CLAVATA3 signaling regulates nuclear-cytoplasmic partitioning of WUSCHEL to control nuclear levels and its diffusion into adjacent cells. Our work also reveals that WUSCHEL directly interacts with EXPORTINS via EAR-like domain which is also required for destabilizing WUSCHEL in the cytoplasm. We develop a combined experimental and computational modeling approach that integrates CLAVATA3-mediated transcriptional repression of WUSCHEL and post-translational control of nuclear levels with the WUSCHEL concentration-dependent regulation of CLAVATA3. We show that the dual control by the same signal forms a seamless connection between de novo WUSCHEL synthesis and sub-cellular partitioning in providing robustness to the WUSCHEL gradient.

An Experiment to Design an Operation and Maintenance System Integrating Apriori Association Rules for a Telecom Platform

The operation and maintenance management of telecom platforms puts more emphasis on operation and alarm monitoring and less on business flow, and it is difficult to have a seamless connection between operation and maintenance and sales. To improve the cooperative efficiency and the informatization level of telecom platform operation and maintenance, a new operation and maintenance system integrating Apriori association rules for a telecom platform is proposed. In this paper, the Apriori algorithm is firstly used to analyse the fault correlation of the operation and maintenance system of the telecommunications platform to get the alarm message. Then, the fault risk of the operation and maintenance platform is evaluated intelligently by the system-business alarm causality model. Finally, based on the fixed end and the mobile end, the dynamic presentation of the system running state and alarm monitoring, device query and positioning, and online and offline inspection are implemented and designed, respectively. Experimental results show that the proposed operation and maintenance systems integrating Apriori association rules for the telecom platform innovate the cooperative mode between the operations and sales team, and the average time reduces to 3.9 minutes from 4.7 minutes and the risk forecasting accuracy increases from 8% to 26%. The assumed method can significantly improve the operational efficiency and intelligent level of the telecom platform’s system and business.

Universal Transceivers: Opportunities and Future Directions for the Internet of Everything (IoE)

The Internet of Everything (IoE) is a recently introduced information and communication technology (ICT) framework promising for extending the human connectivity to the entire universe, which itself can be regarded as a natural IoE, an interconnected network of everything we perceive. The countless number of opportunities that can be enabled by IoE through a blend of heterogeneous ICT technologies across different scales and environments and a seamless interface with the natural IoE impose several fundamental challenges, such as interoperability, ubiquitous connectivity, energy efficiency, and miniaturization. The key to address these challenges is to advance our communication technology to match the multi-scale, multi-modal, and dynamic features of the natural IoE. To this end, we introduce a new communication device concept, namely the universal IoE transceiver, that encompasses transceiver architectures that are characterized by multi-modality in communication (with modalities such as molecular, RF/THz, optical and acoustic) and in energy harvesting (with modalities such as mechanical, solar, biochemical), modularity, tunability, and scalability. Focusing on these fundamental traits, we provide an overview of the opportunities that can be opened up by micro/nanoscale universal transceiver architectures towards realizing the IoE applications. We also discuss the most pressing challenges in implementing such transceivers and briefly review the open research directions. Our discussion is particularly focused on the opportunities and challenges pertaining to the IoE physical layer, which can enable the efficient and effective design of higher-level techniques. We believe that such universal transceivers can pave the way for seamless connection and communication with the universe at a deeper level and pioneer the construction of the forthcoming IoE landscape.Index Terms– Internet of Everything, Universal IoE Transceiver, Interoperability, Multi-modality, Hybrid Energy Harvesting, Molecular Communications, THz Communications, Graphene and related nanomaterials.

Defining a Model for Integrating Indoor and Outdoor Network Data to Support Seamless Navigation Applications

Spaces are continuous realms where human beings freely navigate, such as from indoor to outdoor and optionally to another indoor space. However, currently available data models to represent space for navigation do not entirely reflect this continuity of freedom and movement. Data conversion or complications in implementation hinder current approaches to link indoor space with outdoor space due to the variety of present data models. Furthermore, this representation of indoor–outdoor connection becomes oversimplified during the integration process. Consequently, location-based applications based on these datasets are limited in conveying mobility within these spaces and aiding navigation activity. This paper defines a framework for integrating indoor and outdoor navigable space to enable seamless navigation. This model enables the connection between indoor and outdoor navigation networks. We describe the connections between these networks through spatial relationships, which can be generalized to represent various cases of indoor–outdoor transitional spaces. Using sample datasets, we demonstrate the framework’s potential to provide a seamless connection between indoor and outdoor space in a route analysis experiment.

Ethical Individualism and the Prospect of Confucian Political Theory

In his recent book, Shaun O’Dwyer defends liberal democracy as the only legitimate mode of political system in the East Asian context by critiquing various proposals of Confucian democracy and meritocracy. Underlying O’Dwyer’s critique of Confucian political theory is the seamless connection between ethical individualism (à la Kant), pragmatic democracy (à la Dewey), and political liberalism (à la Rawls), which in his view cannot be adequately accommodated by any version of Confucian political theory, unless it abandons its Confucian essence. This paper argues that the relation between these three philosophical components are far more complex than is rendered by O’Dwyer and that Confucian democracy can be justified on ethical, pragmatic, and progressive grounds.

Volumetric Lattice Boltzmann Method for Wall Stresses of Image-based Pulsatile Flows

Image-based computational fluid dynamics (CFD) has become a new capability for determining wall stresses of pulsatile flows. However, a computational platform that directly connects image information to pulsatile wall stresses is lacking. Prevailing methods rely on manual crafting of a hodgepodge of multidisciplinary software packages, which is usually laborious and error prone. We present a new technique to compute wall stresses in image-based pulsatile flows using the lattice Boltzmann method (LBM). The novelty includes: (1) a unique image processing to extract flow domain and local wall normality, (2) a seamless connection between image extraction and CFD, (3) an en-route calculation of strain-rate tensor, and (4) GPU acceleration (not included here). We first generalize the streaming operation in the LBM and then conduct an application study for laminar and turbulent pulsatile flows in an image-based pipe (Reynolds number: 10 to 5000). The computed pulsatile velocity and shear stress are in good agreement with Womersley solutions for laminar flows and concurrent laboratory measurements for turbulent flows. This technique is being used to study (1) the hemodynamic wall stresses in inner choroid endothelium, (2) the drag force in sand flows, and (3) effects of waste streams on ion exchange kinetics in porous media.

The Whole Process Research On Distribution Network Construction Projects Management Based On Information Management and Control

Distribution network is an important public infrastructure for national economic and social development, bearing the people’s growing expectation for better life. The new time urgently requires the construction of distribution network to be safer, better and more efficient. This paper relies on the team dream information system, Focusing on the safety, quality and schedule requirements of distribution network construction management, giving full play the supporting role of information system in engineering construction management, Creates closed-loop management of process nodes such as project preliminary design and feasibility study, materials, construction, completion, production, settlement and filing, so as to realize seamless connection of project preliminary design and feasibility study, efficient and transparent material management, deep integration of construction completion and close connection of production settlement, improve work efficiency and enhance the construction and management level of distribution network projects.