Research Highlights: In this longitudinal study, we explore the impacts of changing atmospheric composition and increasing aridity on the radial growth rates of western juniper (WJ; Juniperus occidentalis Hook). Since we sampled from study locations with minimal human agency, we can partially control for confounding influences on radial growth (e.g., grazing and logging) and better isolate the relationships between radial growth and climatic conditions. Background and Objectives: Our primary objective is to determine if carbon dioxide (CO2) enrichment continues to be a primary driving force for a tree species positively affected by increasing CO2 levels circa the late 1990s. Materials and Methods: We collected data from mature WJ trees on four minimally disturbed study sites in central Oregon and compared standardized radial growth rates to climatic conditions from 1905–2017 using correlation, moving-interval correlation, and regression techniques. Results: We found the primary climate driver of radial growth for WJ is antecedent moisture over a period of several months prior to and including the current growing season. Further, the moving-interval correlations revealed that these relationships are highly stable through time. Despite a trend toward increasing aridity manifested through significant increases in maximum temperatures during the summer growing season, WJ radial growth post-1960 exceeds growth pre-1960, especially during drought years. Our results support prior conclusions that increasing atmospheric CO2 increases water-use efficiency for this semiarid species, which allows the trees to continue to grow during climatic periods negatively associated with radial growth. Conclusions: Recent studies have shown that semiarid ecosystems are important for understanding global variations in carbon uptake from the atmosphere. As WJ woodlands cover an extensive region in western North America and have undergone rapid expansion during the 20th and 21st centuries, they may become an increasingly important carbon sink.