AbstractSolving urban wastewater management problems requires knowledge of wastewater composition and variability. In the case of combined sewerage, this applies to both dry and wet weather. Wastewater composition is changing as a result of the appearance of new substances on the market, the changes in inhabitant lifestyle and the catchment characteristic; therefore, it must be constantly monitored. At the same time, due to the time-consuming and high costs of measurement campaigns, solutions that could limit their scope and facilitate the interpretation of the results are sought. This paper presents the results of the measurement campaign conducted in 2018–2021. The aim of the monitoring was, inter alia, assessment of wastewater composition in terms of threats to wastewater treatment plant and urban rivers, which are receivers of discharge from combined sewer overflows. The obtained results were analyzed using the multivariate statistical methods: Principal Component Analysis and Cluster Analysis. However, the applied methods did not allow for the full identification of the relationship between the wastewater quality parameters as well as the differences and similarities in the wastewater composition from individual parts of the city, which could simplify and reduce the measurement campaigns in the future. Therefore, in the case of large urban catchments, it is necessary to introduce other solutions to control the wastewater composition.