A variety of pipelines are distributed under urban roads. The upgrading of pipelines is bound to occupy certain road resources, compress the driving space of motor vehicles for a long time, aggravate the traffic congestion in the construction section, and then affect the traffic operation of the whole region. A reasonable layout of traffic signs for inducement to guide the traffic flow in the area where the construction section is located is conducive to promoting a balanced distribution of traffic flow in the regional road network, so as to achieve the reduction of automobile exhaust emissions and the sustainable development of traffic. In this paper, the layout optimization method of regional traffic signs for inducement is proposed. Taking the maximum amount of guidance information that the regional traffic signs can provide as the objective function, and taking the traffic volume, the characteristics of intersection nodes and the standard deviation of road saturation as the independent variables, the layout optimization model of guidance facilities is constructed, which can optimize the layout of traffic guidance signs in the area affected by the construction section, and achieve the goal that the minimum number of facilities can provide the maximum amount of guidance information. The results of the case study show that among the 64 alternative locations where traffic guidance signs can be set in the study area, eight optimal locations are finally determined as the setting points of guidance facilities through this model, and the effective increment of guidance information is the largest at this time. The model proposed in this paper can be used for reference to promote the sustainable development of traffic in the area where the construction section is located.