serous ovarian adenocarcinoma
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2021 ◽  
Vol 116 (1) ◽  
pp. S1272-S1272
Author(s):  
Basel Humos ◽  
Zachary Sherman ◽  
David Wan

2021 ◽  
Author(s):  
Yeon Jeong Kim ◽  
Jin Park ◽  
Hyeon Hee Jeong ◽  
Ji Eun Baek ◽  
Seung-Mo Hong ◽  
...  

Abstract Ovarian cancer is the deadliest gynecological cancer and when diagnosed at advanced stages the five-year survival rate is typically less than 30%. Pancreatic adenocarcinoma up-regulated factor (PAUF) plays a crucial role in tumor progression, angiogenesis, and immune evasion in the pancreatic tumor microenvironment. The current study aimed to characterize the potential tumorigenic role of PAUF in serous ovarian cancer as high expression of the factor is correlated with poor prognosis in epithelial ovarian cancer. Extracellular treatment with recombinant PAUF activated intracellular signal pathways that subsequently led to enhanced proliferation, migration, and invasion in various serous ovarian adenocarcinoma cell lines. A PAUF-knockout OVCAR-5 cell line demonstrated an apparent reduction in tumor incidence and delayed tumor growth in mouse xenograft experiments. Furthermore, the administration of an anti-PAUF antibody exhibited a notable therapeutic efficacy in mice bearing the OVCAR-5 cell line-derived xenograft tumors. Taken together, our results suggest that PAUF plays a role in the progression of serous ovarian adenocarcinoma and may serve as a novel therapeutic target of the disease.


2020 ◽  
Author(s):  
Hayat Erraichi¹ ◽  
Niaina Ezra RANDRIAMANOVONTSOA¹ ◽  
valère LITIQUE¹ ◽  
Karima OUALLA² ◽  
Zineb BENBRAHIM² ◽  
...  

Abstract Background: Gastric metastases due to ovarian carcinoma are extremely rare and the patients' prognosis is poor. We report a case of gastric ovarian cancer metastases revealed by gastrosplenic perforation. The secondary gastric tumor appeared seven years after the diagnosis of primary cancer.Case presentation:The patient is a 71-year-old woman with a serous ovarian cancer hospitalized for asthenia with digestive hemorrhage. At esophagogastroduodenoscopy, a protruding mass was noted at the level of the gastric antrum. She underwent a hemostasis of an endoscopic hemostasis by argon plasma; with effective hemostasis. The final pathology revealed gastric metastases of serous ovarian adenocarcinoma. Weekly gemcitabine chemotherapy was adopted, but the disease progressed rapidly. The patient died 4 months later.Conclusion:We have reported a case of gastric metastasis of ovarian tumor origin revealed by digestive hemorrhage. This work reiterates that this secondary localization of this cancer is possible although extremely rare. Studies are still needed to elucidate much of this unclear situation.


2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Ruru Zhu ◽  
Jisen Xue ◽  
Huijun Chen ◽  
Qian Zhang

2019 ◽  
Vol 44 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Xiaobo Yao ◽  
Jiaqiong Wang ◽  
Menghua Xia ◽  
Junyong Xia ◽  
Yizhuang Cheng

Apmis ◽  
2017 ◽  
Vol 125 (10) ◽  
pp. 857-862 ◽  
Author(s):  
Xiaomei Fan ◽  
Lixuan Wen ◽  
Yuehong Li ◽  
Lei Lou ◽  
Weina Liu ◽  
...  

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