The Distinguished Scientist designation honors American Heart Association professional members who have made extraordinary contributions to cardiovascular and stroke research. The American Heart Association’s Distinguished Scientists are a prominent group of scientists and clinicians whose work has importantly advanced our understanding of cardiovascular diseases and stroke. This award was created over 10 years ago to recognize American Heart Association members for significant, original and sustained scientific contributions that have advanced the association’s mission “Building healthier lives, free of cardiovascular diseases and stroke.” Recipients of this prestigious award are honored during the Presidential Session at American Heart Association Scientific Sessions. We would like to congratulate the 2 receipts under the councils that Hypertension represents. Congratulations to Italo Biaggioni, MD, PhD, FAHA on behalf of the Hypertension council and Ernesto L. Schiffrin, MD, PhD, FAHA on behalf of the Hypertension & KCVD council. In the profiles that follow, we would like to highlight their accomplishments and congratulate them on being named the 2021 Distinguished Scientists.