This research intends to evaluate the effects of the waste polyethylene terephthalate (PET), antistripping agents (ASA), and ground tire rubber (GTR) on the performance properties of the stone matrix asphalt (SMA) mix binder/water damage resistance. Liquid antistripping agents, added to 85/100 penetration grade binder to evaluate the ASA effects, were A (M500), B (EvothermM1), and C (LOF-6500). Tests conducted to study the modified bitumen’s rheological properties included softening point, penetration, rotational viscosity (RV), and dynamic shear rheometer (DSR), and tests performed in order to examine the moisture sensitivity of the modified mix were the Texas boiling and resilient modulus (MR), fracture energy (FE), and indirect tensile strength (ITS) ratio tests. Results showed that the MR, ITS, and FE of asphalt mixes modified with crumb rubber (CR), ASA, and PET were improved. Adding 50% PET, 50% CR, and ASA (B) led to the highest tensile strength, resilient modulus, and fracture energy ratios showing a perfect water susceptibility of the mentioned mix.