Gangraena i remedium, o herezjach i zwyrodnieniu religijnym w Anglii połowy XVII w.

Gangraena and its cure: on Heresies and Religious Perversions in mid-seventeenth century England The English Civil War saw an explosion in the production of printed material. Booklets, pamphlets, leaflets, and ballads of all types and covering all manner of subjects appeared in their thousands. Indeed, the number of titles printed during this period surpassed 2,000 per year. Among these we find a large category of prints denouncing religious heresy and perverse behaviors. The most elaborate of these was Thomas Edwards’s Gangraena, which ran to several thousand pages in length and spanned three consecutive volumes. In this article, the author looks at various religious sects in England and aspects of their beliefs and behaviors to examine how the Restoration England of Charles II tried to cure its population of unorthodox and perverse religious ideas.

Penalty for violating the professional companies system in the Saudi system: A comparative study: جَزاء مُخَالَفَة نظام الشَّرِكات المِهَنِيَّة في النظام السعودي: دِرَاسة مُقارنة

System of Professional Companies is considered one of the modern matters of concern to a large category of professionals, and due to the absence of a previous scientific study, and owing to the significance of the subject, this study aimed to demonstrate the penalty for violating the system of professional companies in legal system of Saudi Arabia (Comparative Study), between the law in the legal system of Saudi Arabia and Islamic jurisprudence The researcher followed the descriptive comparative approach, with a focus on the penalty for violating the provisions of the system of professional companies, as it is in fact in the system approved by the Saudi government and comparing it with Islamic jurisprudence to demonstrate its compatibility with Islamic law (Islamic Sharia). The study concluded that in defining the penalty we find that it includes, in the system of professional companies, for a worldly penalty, in contrast to Islamic jurisprudence, which has arranged for a worldly penalty and a hereafter penalty, and that the system of professional companies, in imposing a financial fine on the violator, is consistent with the doctrine of the majority of jurists. The study recommended severe proposals including: The legislator shall stipulate the penalty for not obtaining coverage insurance and the legislator must take care of the community’s conditions and what is appropriate for its interests.

Characterization of A Novel Autoimmune Encephalitis Associated Antibody against CRMP2

ABSTRACTObjective Autoimmune encephalitis (AE) is a large category disorder urging antibody characterization. The aim was to identify a novel AE related autoantibody targeting an intracellular synaptic protein. Methods Suspected AE patients had negative conventional antibodies screening but strong immunolabel signals on rat brain sections with the serum and cerebrospinal fluid (CSF) samples were considered burdening unkown antibody. Immunoprecipitation from the rat brain protein lysate followed by mass spectrometry analysis was used to identify the targeting antigen. Western blotting and/or cell-based assay (CBA) with antigen-overexpressing HEK293T cells were used for antibody specificity, epitope and IgG subtype determination. Patients with similar immunostaining pattern on rat brain sections were retrospectively screened for the antibody. Results The antibody against collapsin response mediator protein 2 (CRMP2), a synaptic protein involved in axon guidance, was identified in a patient with suspected AE. The patient samples reactivated with HEK293T cell overexpressed CRMP2, rather than CRMP1, 3, 4, and 5. The patient samples mainly stained neuronal cytoplasm of the cortex, hippocampus and cerebellum Purkinje cells. This reactivity was eliminated by pre-immunoabsorption with CRMP2-overexpressing HEK293T cells. CRMP2 truncation experiments indicated that 536 amino acids at C-terminus was necessary for the epitope. Subtype analysis showed that anti-CRMP2 antibody was IgG4. Moreover, screening from 19 suspected AE patients led to identification of anti-CRMP2 antibody in another patient with a diagnosis of encephalomyelitis. The two patients responded to immunotherapy. Conclusions This study discovered a novel anti-CRMP2 antibody associated with AE. Testing of the antibody might be promising for AE diagnosis and treatment.

Prioritizing Cancer lncRNA Modulators via Integrated lncRNA-mRNA Network and Somatic Mutation Data

Background: Long noncoding RNAs (LncRNAs) represent a large category of functional RNA molecules that play a significant role in human cancers. lncRNAs can be genes modulators to affect the biological process of multiple cancers.Methods: Here, we developed a computational framework that uses lncRNA-mRNA network and mutations in individual genes of 9 cancers from TCGA to prioritize cancer lncRNA modulators. Our method screened risky cancer lncRNA regulators based on integrated multiple lncRNA functional networks and 3 calculation methods in network. Results: Validation analyses revealed that our method was more effective than prioritization based on a single lncRNA network. This method showed high predictive performance and the highest ROC score was 0.836 in breast cancer. It’s worth noting that we found that 5 lncRNAs scores were abnormally high and these lncRNAs appeared in 9 cancers. By consulting the literatures, these 5 lncRNAs were experimentally supported lncRNAs. Analyses of prioritizing lncRNAs reveal that these lncRNAs are enriched in various cancer-related biological processes and pathways.Conclusions: Together, these results demonstrated the ability of this method identifying candidate lncRNA molecules and improved insights into the pathogenesis of cancer.

KONTRIBUSI PENDAPATAN PEKERJA USAHA BERKAH CONE TERHADAP PENDAPATAN KELUARGA DI KELURAHAN SUMOMPO KECAMATAN TUMINTING KOTA MANADO

This study aimed to determine the contribution of income of the Berkah Cone business workers to their family income. This research was conducted for 3 months, starting from January to March 2020. The data used in this study were primary and secondary data. Primary data were obtained from direct interviews with Berkah Cone business workers and Berkah Cone business owners. Secondary data were obtained from monographs of Sumompo Sub-district and literature related to research. The sampling method used was a census to all workers consisted of 12 people. The results of this study indicated that the income of the Berkah Cone business workers has a 69.75% contribution to the family income. The value of 69.75% according to the contribution assessment criteria belongs to the very large category (> 50%). This means that the income earned by workers in the Blessing Cone business greatly helped their families and themselves in fulfilling theirdaily needs and making a real contribution to the family income.

Magia manei în cultura populară din Maramureș

"The magic of manna in the folk culture of Maramureş Based on our direct field research, we have dedicated this study to a very rich chapter of magic, that of manna (abundance), as it appears in the folk culture of Maramureş. In the first part we analyzed the concept of the manna in the Romanian and the universal folk culture, but also the categories of rites through which the magic of the abundance is performed. We reserved the investigation part to the rites of defense, conservation and magical stimulation of the fields production. In this chapter we have focused on the rites that are practiced at certain times considered by people to be critical : the beginning of ploughing and sewing. We have reserved due space to the study of the rites related to the abundance of the fields in the spring customs, which represent a large category, then in the rites within the winter customs. A large of our research was dedicated to the rites related to the defense and magical stimulation of animal products abundance. In this chapter too, we focused on the rites dedicated to critical moments: taking out the sheep, climbing the sheep in the mountains, the first milking. In our research, we have dealt extensively with the categories of rites related to the defense and stimulation of cow milk production. A chapter of our study approaches the magical practices of stimulating tree fruits abundance, some preserved in traditional customs such as the threat to the barren tree. In this chapter we analyzed reminiscences of the stimulation of the manna of the trees in the old carols, such as ""White apple flowers"". Another chapter of our research is dedicated to the rites of stimulating the abundance of poultry products. A complex chapter is devoted to the rites of taking away the manna of milking animals. I have reserved an equally extensive chapter to the rites of getting back the manna of milking animals, at the end of the research. Keywords: manna, rite, animal, custom, tree "

Location analysis of manufacturing activity in Greece: A point pattern analysis

This paper implements a point pattern analysis using a novel dataset with exact coordinates of statistical data for Greek manufacturing industry. Specifically, the dataset comprises the precise location of 2.452 observations of enterprises including 146.923 employees. For the year 2018 these industries are divided into twenty-four two-digit NACE 2 sub-industries of manufacturing activity. The method of point pattern analysis permits the estimation of the pattern in manufacturing activity across space. The highest agglomeration appears to be taking place in sectors of High (H) technological intensity as well as in the Middle High (M-H) sectors. In addition, sectors belonging to the middle category and the large category according to the number of employees tend to be more agglomerated in space. Findings reveal that the level of concentration or dispersion differs substantially among different sectors underlying the specialization and dispersion of economic activity in the country.

6. Authoritarian Regimes

For many years, the concept of an authoritarian regime was considered to be one large category, with little understanding of how these regimes differed. The study of authoritarian regimes has come a long way since. Though all authoritarian regimes share in common that there is no turnover in power of the executive, there are considerable differences that distinguish autocracies. Authoritarian regimes today are increasingly attempting to use ‘democratic’ institutions to prolong their rule. This has led to a rise in competitive authoritarian regimes, or hybrid regimes. In spite of these changes, authoritarian regimes are more robust than ever. This chapter explains the different ways in which authoritarian regimes are categorized. The chapter then explains how the different types of authoritarian regimes perform, and what factors make them more durable. As the chapter demonstrates, autocratic regimes have become increasingly better equipped to maintain themselves.

Changing Logics in Healthcare and Their Effects on the Identity Motives and Identity Work of Doctors

Recent literature on hybridity has provided useful insights into how professionals have responded to changing institutional logics. Our focus is on how shifting logics have shaped senior medical professionals’ identity motives and identity work in a qualitative study of hospital consultants in the United Kingdom’s National Health Service. We found a binary divide between a large category of traditionalist doctors who reject shifting logics, and a much smaller category of incorporated consultants who broadly accept shifting logics and advocate change, with little evidence of significant ambivalence or temporary identity ‘fixes’ associated with liminality. By developing a new inductively generated framework, we show how the identity motives and identity work of these two categories of doctors differ significantly. We explore the underlying causes of these differences, and the implications they hold for theory and practice in medical professionalism, medical professional leadership and healthcare reform.

Studies on the Culture Condition of Pangus (Pangasius hypophthalmus) at Different Farms in Trishal Upazila

The present study was conducted to investigate existing culture conditions of pangus (Pangasius hypophthalmus) at farms in Trishal Upazila under Mymensingh district during January to June, 2016. Data were collected with questionnaire by personal interviewing of the respondents. The study result showed that- the farmers of large category are about 60% where 47% farmers have leased pond. Most of the farmer use deep tube-well water as source, 87% farmers practice monoculture of pangus and monitored the health of fish in a regular basis. Only 13% farmer reported diseases occurred in their pond. Most of the pangus farmers used homemade or local farm made supplementary feeds for pangus culture. The study showed that development of better farming system, improving water management, stocking of quality fingerlings, health monitoring and use of prime and standard quality feed has resulted better pangus production in Trishal area. J. Environ. Sci. & Natural Resources, 11(1-2): 97-107 2018