Exploration and development of unconventional reservoirs, where fractures and in-situ stresses play a key role, call for improved characterization workflows. Here, we expand on a previously proposed method that makes use of standard isotropic modeling and inversion techniques in anisotropic media. Based on approximations for PP-wave reflection coefficients in orthorhombic media, we build a set of transforms that map the isotropic elastic parameters used in prestack inversion into effective anisotropic elastic parameters. When used in isotropic forward modeling and inversion, these effective parameters accurately mimic the anisotropic reflectivity behavior of the seismic data, thus closing the loop between well-log data and seismic inversion results in the anisotropic case. We show that modeling and inversion of orthorhombic anisotropic media can be achieved by superimposing effective elastic parameters describing the behavior of a horizontally stratified medium and a set of parallel vertical fractures. The process of sequential forward modeling and postinversion analysis is exemplified using synthetic data.