In this chapter, machine learning application on facial expression recognition (FER) is studied for seven emotional states (disgust, joy, surprise, anger, sadness, contempt, and fear) based on FER describing coefficient. FER has many practical importance in various area like social network, robotics, healthcare, etc. Further, a literature review of existing machine learning approaches for FER is discussed, and a novel approach for FER is given for static and dynamic images. Then the results are compared with the other existing approaches. The chapter also covers additional related issues of applications, various challenges, and opportunities in future FER. For security-based face detection systems that can identify an individual, in any form of expression he introduces himself. Doctors will use this system to find the intensity of illness or pain of a deaf and dumb patient. The proposed model is based on machine learning application with three types of prototypes, which are pre-trained model, single layer augmented model, and multi-layered augmented model, having a combined accuracy of approx. 99%.