Generations of scholars have attempted, without success, to link Spanish-American silver to the dawn of European capitalism. Rather, historical connections across the globe have come into clearer focus during recent decades, including awareness of the fact that American, European, and Japanese silver gravitated largely to China (and also India). Having begun during the sixteenth century, globalization has involved deep connections, including trade regimes that linked together multiple free and coerced labour systems simultaneously. Lessons from global history suggest that national ‘capitalisms’ can no longer serve as reasonable units of analysis. From the outset of sixteenth-century origins, globalization generated intertwined economic, environmental, epidemiological, demographic, and cultural accumulations that continue to reverberate across planet Earth today. Wealth creation, wealth distribution, and environmental consequences remain central features of a historical process that requires analysis at a global level.