Issues of scientific and technological development of the economy, increasing its competitiveness, including various aspects of technological integration, are the subject of foreign and domestic research. At the same time, technological integration is considered as a key direction of the new industrial and scientific-technical policy, as a means of transition to the digital economy, to production processes with higher added value, as a means of establishing a constructive dialogue between industrial enterprises and science. The reason for this is, on the one hand, the relative novelty of this economic phenomenon, and, on the other, the lack of theoretical and methodological tools for modelling the development of technological integration. The purpose of the article is to study the problems of modelling the development of technological integration in the context of priority scientific and technological development of the Russian economy. The article uses a wide range of general scientific methods: analysis and synthesis, grouping, typing, modelling, economicstatistical and graphical. The main methodological approaches used in the article are: structural-functional, instrumental and process approaches, which are reflected in the scientific and practical material of the general theory of systems, the theory of organization. The theoretical results of the study are the disclosure of the organizational model for the development of technological integration as a dynamic set of interconnected modules: management and coordination; structure; processes; resources designated to achieve the strategic objectives of technology integration participants. Classification characteristics of technological integration development processes have been identified and theoretically justified. The applied result is a specialized modelling tool based on a combination of a standardized approach and improved design quality with the ability to test simulated processes and the presence of stable feedback with all participants in technological integration. The process model of technological integration development was argued, its decomposition was carried out, which allows distinguishing the main, supporting and regulatory processes of participants in technological integration. The combination of these models facilitates the management of these processes in order to maximize the efficiency of the modern economy. An organizational and economic mechanism for modelling the development of technological integration is proposed, which allows the use of operational monitoring, due to the vector orientation of which it becomes possible to promptly carry out regular adjustments of key parameters of assessing the impact of technological integration on the results of technological development in national economies.