This chapter considers the increasingly prevalent presence of a ‘hybrid’ hero, a hybrid of human and vampire and/or zombie, within 21st century vampire and zombie films and television. Through an examination of a selection of special-effects driven, hybrid horror/science-fiction films, this chapter considers how the hybrid hero celebrates notions of hybridity through the figure of the post-human, or cyborg, hero while also challenging conceptions of racial purity and the controlling doctrines of contemporary bio-politics. These heroes defy accepted behaviour, perceived racial boundaries, physical limitations and the boundaries of the body, reimaging the human as a hybrid form in which the lines between human, machine and monster are blurred. In so doing, they invite the audience to embrace hybridity in all of its forms and see the world through the eyes of the monster. Case studies include Buffy the Vampire Slayer, Blade, Underworld, Ultraviolet and Resident Evil.