Lysine methyltransferase inhibitors: where we are now.

Protein lysine methyltransferases constitute a large family of epigenetic writers which catalyse the transfer of a methyl group from the cofactor S-adenosyl-L-methionine to histone and non-histone specific substrates. Alterations in...

Molecular probes for cellular imaging of post-translational proteoforms

Specific post-translational modification (PTM) states of a protein affect its property and function; understanding their dynamics in cells would provide deep insight into diverse signaling pathways and biological processes. However,...

Combating the amyloid-induced cellular toxicity and stiffness by designer peptidomimetics

Amyloid beta (Aβ) aggregation species-associated cellular stress instigates cytotoxicity and adverse cellular stiffness to neuronal cells. The study and modulation of these adverse effects demand immediate attention to tackle Alzheimer’s...

Phosphorylated resveratrol as a protein aggregation suppressor in-vitro and in-vivo

The stability of proteins in solution poses a great challenge for both, technical applications and molecular biology including neurodegenerative diseases. In this work, a phosphorylated resveratrol material was examined for...

A COVID-19 vaccine candidate composed of SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles

SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host’s cellular receptor. Vaccines seek to block this interaction by eliciting...

Embedding a Membrane Protein into an Enveloped Artificial Viral Replica

Natural enveloped viruses, in which nucleocapsids are covered with lipid bilayers, contain membrane proteins on the outer surface that are involved in diverse functions, such as adhesion and infection of...

Computational analyses of mechanism of action (MoA): data, methods and integration

This review summarises different data, data resources and methods for computational mechanism of action (MoA) analysis, and highlights some case studies where integration of data types and methods enabled MoA elucidation on the systems-level.