Acellular Cerebrospinal Fluid With Elevated Protein Level in Patients With Intermittent Acute Porphyria

1989 ◽  
Vol 149 (7) ◽  
pp. 1695 ◽  
Author(s):  
GUILLERMO LATORRE
Keyword(s):  
Cerebrospinal Fluid ◽  
Protein Level ◽  
Acute Porphyria ◽  
Elevated Protein ◽  
Intermittent Acute Porphyria ◽  
Elevated Protein Level

scholarly journals New-Onset Seizure With Possible Limbic Encephalitis in a Patient With COVID-19 Infection: A Case Report and Review

2021 ◽  
Vol 9 ◽  
pp. 232470962098630
Author(s):  
Riwaj Bhagat ◽  
Barbara Kwiecinska ◽  
Nolan Smith ◽  
Matthew Peters ◽  
Christopher Shafer ◽  
...  
Keyword(s):  
Brain Magnetic Resonance Imaging ◽  
Nasopharyngeal Swab ◽  
Onset Seizure ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Global Pandemic ◽  
Elevated Protein ◽  
T2 Hyperintensity ◽  
Elevated Protein Level ◽  
New Onset

With the outbreak of COVID-19 (coronavirus disease 2019) as a global pandemic, various of its neurological manifestations have been reported. We report a case of a 54-year-old male with new-onset seizure who tested positive for severe acute respiratory syndrome coronavirus 2 from a nasopharyngeal swab sample. Investigative findings, which included contrast-enhancing right posterior temporal lobe T2-hyperintensity on brain magnetic resonance imaging, right-sided lateralized periodic discharges on the electroencephalogram, and elevated protein level on cerebrospinal fluid analysis, supported the diagnosis of possible encephalitis from COVID-19 infection. The findings in this case are placed in the context of the existing literature.

HaNDL Syndrome: Case Report and Literature Review

2018 ◽  
Vol 34 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Amy Armstrong-Javors ◽  
Kalpathy Krishnamoorthy
Keyword(s):  
Cerebrospinal Fluid ◽  
Literature Review ◽  
Severe Headache ◽  
Resonance Imaging ◽  
Neurologic Deficits ◽  
Elevated Protein ◽  
Episodic Nature ◽  
Magnetic Resonance Imaging Mri ◽  
Fundoscopic Examination ◽  
Pathophysiologic Mechanisms

Headache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome is a rare stroke mimicker characterized by moderate to severe headache temporally associated with transient neurologic deficits, typically hemiparesis, hemisensory disturbance, and/or aphasia. Cerebrospinal fluid studies reveal a lymphocytosis and elevated protein. Episodes recur over a period no longer than 3 months. Here we describe the case of a 16-year-old boy who presented with 3 episodes of self-resolving neurologic deficits, papilledema on fundoscopic examination, and leptomeningeal enhancement on magnetic resonance imaging (MRI). We additionally review the 30 previously reported pediatric cases of HaNDL syndrome, with a focus on possible etiologic and pathophysiologic mechanisms of disease. The reported case and literature review highlight the benign episodic nature of this likely underrecognized syndrome as well as the higher than expected frequency of abnormal neuroimaging findings.

Liver transplantation for intermittent acute porphyria resistant to medical treatment

2021 ◽  
Author(s):  
Cándido Alcázar López ◽  
Gonzalo P. Rodríguez Laiz ◽  
Rosario Sánchez Martínez ◽  
Sonia Pascual Bartolome ◽  
José Manuel Ramia
Keyword(s):  
Liver Transplantation ◽  
Medical Treatment ◽  
Acute Porphyria ◽  
Intermittent Acute Porphyria

scholarly journals Cerebrospinal Fluid in Posterior Reversible Encephalopathy Syndrome: Implications of Elevated Protein and Pleocytosis

2018 ◽  
Vol 9 (2) ◽  
pp. 58-64 ◽  
Author(s):  
Colin A. Ellis ◽  
Andrew C. McClelland ◽  
Suyash Mohan ◽  
Emory Kuo ◽  
Scott E. Kasner ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
White Blood Cells ◽  
Radiographic Severity ◽  
Posterior Reversible Encephalopathy ◽  
Radiologic Findings ◽  
Csf Analysis ◽  
Elevated Protein ◽  
Reversible Encephalopathy ◽  
Csf Findings

Background and Purpose: Patients with posterior reversible encephalopathy syndrome (PRES) sometimes undergo analysis of cerebrospinal fluid (CSF) to exclude alternative diagnoses. This study’s objectives were to describe the CSF characteristics in patients with PRES and to identify clinical and radiologic findings associated with distinct CSF abnormalities. Methods: We identified a retrospective cohort of patients with PRES. We compared clinical and radiographic characteristics of those who did versus did not undergo lumbar puncture, described the observed range of CSF findings, and analyzed clinical and radiographic features associated with specific CSF abnormalities. Results: A total of 188 patients were included. Patients with (n = 77) and without (n = 111) CSF analysis had similar clinical and radiographic characteristics. Cerebrospinal fluid protein was elevated in 46 (60%) of 77, with median CSF protein 53 mg/dL (upper limit of normal 45 mg/dL). Protein elevation was significantly associated with radiographic severity ( P = .0058) but not with seizure, time from symptom onset, radiographic evidence of diffusion restriction, or contrast enhancement. Five (7%) patients had elevated CSF white blood cells, all of whom had infarction and/or hemorrhage on neuroimaging, and 4 of whom had eclampsia. Conclusion: The CSF of most patients with PRES shows a mild protein elevation commensurate with radiographic severity. Cerebrospinal fluid pleocytosis may mark a distinct subtype of PRES with predisposition toward infarction and/or hemorrhage. These findings help clinicians interpret CSF findings in these patients and generate new hypotheses about the pathophysiology of this syndrome.

Oxygen toxicity related to exposure to lead.

1985 ◽  
Vol 31 (10) ◽  
pp. 1673-1676 ◽  
Author(s):  
H P Monteiro ◽  
D S Abdalla ◽  
A S Arcuri ◽  
E J Bechara
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Protoporphyrin Ix ◽  
Oxygen Toxicity ◽  
Oxygen Species ◽  
Acute Porphyria ◽  
Dose Response Relationship ◽  
Activated Oxygen ◽  
Exposed Workers ◽  
Intermittent Acute Porphyria

Abstract We evaluated superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) activities in the erythrocytes of lead-exposed and nonexposed workers from distinct industries localized in the State of São Paulo, Brazil. Concentrations of either lead or protoporphyrin IX, or both, in blood were used to indicate the extent of exposure. In all cases, values for superoxide dismutase were significantly higher in the exposed workers. The dose-response relationship between this enzyme and lead concentrations was roughly linear for the workers with greater than 40 micrograms of lead per 100 g of blood. Except for the sample from one of the industries, the corresponding glutathione peroxidase activities were also significantly higher in lead-exposed workers. These data, together with those previously found for patients with intermittent acute porphyria, suggest that in both groups the accumulation of heme precursors is connected to the exacerbated production of activated oxygen species.

Intermittent Acute Porphyria Treated with Chlorpromazine

1957 ◽  
Vol 256 (7) ◽  
pp. 309-311 ◽  
Author(s):  
Robert N. Monaco ◽  
Robert D. Leeper ◽  
Jacob J. Robbins ◽  
George L. Calvy
Keyword(s):  
Acute Porphyria ◽  
Intermittent Acute Porphyria
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