How to learn in an incomplete knowledge environment: Structured objects for a modal approach

Author(s):  
Eric Auriol
Author(s):  
Matteo Baldoni ◽  
Laura Giordano ◽  
Alberto Martelli ◽  
Viviana Patti

Jurnal KATA ◽  
2017 ◽  
Vol 1 (2) ◽  
pp. 192 ◽  
Author(s):  
Silvia Utami

<p>This research aimed to identify types of translation errors and to find out the sources of errors (interlingual and intralingual errors) in Indonesian-English translation written by the students. The type of this research was descriptive research which used Error Analysis procedures to identify and analyze the students’ error. The findings showed that the types of grammatical errors made by the students in their translation were three types, namely global errors, local errors, and other errors. The most frequent error made by the students was local errors and the fewest error made by the students was other errors.  Then, this research revealed that mostly errors occurred in students’ translation were caused by intralingual error. Meanwhile, only few errors were caused by interlingual error. The errors occured due students’ incomplete knowledge of the target language.</p>


2019 ◽  
Vol 24 ◽  
pp. 390-397 ◽  
Author(s):  
Marco Maurizi ◽  
Filippo Cianetti ◽  
Janko Slavič ◽  
Guido Zucca ◽  
Massimiliano Palmieri

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Francesco Simone Ruggeri ◽  
Johnny Habchi ◽  
Sean Chia ◽  
Robert I. Horne ◽  
Michele Vendruscolo ◽  
...  

AbstractSignificant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer’s and Parkinson’s diseases. However, no disease-modifying drug has become available for clinical use to date for these conditions. One of the main reasons for this failure is the incomplete knowledge of the molecular mechanisms underlying the process by which small molecules interact with protein aggregates and interfere with their aggregation pathways. Here, we leverage the single molecule morphological and chemical sensitivity of infrared nanospectroscopy to provide the first direct measurement of the structure and interaction between single Aβ42 oligomeric and fibrillar species and an aggregation inhibitor, bexarotene, which is able to prevent Aβ42 aggregation in vitro and reverses its neurotoxicity in cell and animal models of Alzheimer’s disease. Our results demonstrate that the carboxyl group of this compound interacts with Aβ42 aggregates through a single hydrogen bond. These results establish infrared nanospectroscopy as a powerful tool in structure-based drug discovery for protein misfolding diseases.


1980 ◽  
Vol 3 (2) ◽  
pp. 171-180
Author(s):  
J.A. Bergstra ◽  
H.J.M. Goeman ◽  
A. Ollongren ◽  
G.A. Terpstra ◽  
Th.P. van der Weide
Keyword(s):  

A set of axioms for structured objects of data is presented. In the structured objects components and levels are distinguished. Change of level is the result of a special application operator, components are accessible by successive selections. The set of access paths is also axiomatized. The set of axioms is uniform in the sense that features of various known classes of datastructures are combined.


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