The Role of the Sentinel Lymph Node Biopsy in the Treatment of Nonmelanoma Skin Cancer and Cutaneous Melanoma

2020 ◽  
pp. 647-704
Author(s):  
Grigorios Champsas ◽  
Othon Papadopoulos
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Skin Cancer ◽  
Cutaneous Melanoma ◽  
Lymph Node Biopsy ◽  
Nonmelanoma Skin Cancer ◽  
Node Biopsy

scholarly journals Sentinel Lymph Node Biopsy in Nonmelanoma Skin Cancer Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Marie-Laure Matthey-Giè ◽  
Ariane Boubaker ◽  
Igor Letovanec ◽  
Nicolas Demartines ◽  
Maurice Matter
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Skin Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Lymph Node Biopsy ◽  
Nonmelanoma Skin Cancer ◽  
Node Dissection ◽  
Node Biopsy

The management of lymph nodes in nonmelanoma skin cancer patients is currently still debated. Merkel cell carcinoma (MCC), squamous cell carcinoma (SCC), pigmented epithelioid melanocytoma (PEM), and other rare skin neoplasms have a well-known risk to spread to regional lymph nodes. The use of sentinel lymph node biopsy (SLNB) could be a promising procedure to assess this risk in clinically N0 patients. Metastatic SNs have been observed in 4.5–28% SCC (according to risk factors), in 9–42% MCC, and in 14–57% PEM. We observed overall 30.8% positive SNs in 13 consecutive patients operated for high-risk nonmelanoma skin cancer between 2002 and 2011 in our institution. These high rates support recommendation to implement SLNB for nonmelanoma skin cancer especially for SCC patients. Completion lymph node dissection following positive SNs is also a matter of discussion especially in PEM. It must be remembered that a definitive survival benefit of SLNB in melanoma patients has not been proven yet. However, because of its low morbidity when compared to empiric elective lymph node dissection or radiation therapy of lymphatic basins, SLNB has allowed sparing a lot of morbidity and could therefore be used in nonmelanoma skin cancer patients, even though a significant impact on survival has not been demonstrated.

Clinical Relevance of Sentinel Lymph Node Status Examined with Conventional Histology and Molecular Biology

2009 ◽  
Vol 95 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Rocco Micciolo ◽  
Sebastiana Boi ◽  
Loredana Paoli ◽  
Paolo Cristofolini ◽  
Salvatore Girlando ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Molecular Biology ◽  
Cutaneous Melanoma ◽  
Lymph Node Biopsy ◽  
Lymph Node Status ◽  
Node Biopsy ◽  
Conventional Histology

Aims and background The presence of nodal metastases in patients with primary cutaneous melanoma adversely affects the biological behavior and is related to a poor prognosis. The role of sentinel lymph node biopsy is still debated. The aim of this study was to evaluate the prognostic role of sentinel lymph node biopsy with respect to disease-free period and overall survival. Patients and methods Patients with invasive cutaneous melanoma who underwent sentinel lymph node biopsy in the Santa Chiara Hospital of Trento between October 1997 and December 2002 were evaluated. The lymph nodes were examined with conventional histology, S100 and tyrosinase in immunohistochemistry, and tyrosinase in molecular biology. Results There were 144 patients with 198 sentinel lymph nodes. A significant association was found in conventional histology with Clark level and Breslow thickness. The prognostic role of sentinel lymph node status was independent of the other considered variables. However, no significant association was found with the molecular biology test. A significant excess of positive results at molecular biology was found. Conclusions Sentinel lymph node biopsy is an important independent prognostic factor for invasive cutaneous melanoma, but only when evaluated with conventional histology. As a result of this study, we stopped performing the tyrosinase test in molecular biology.

67P The role of FDG PET/CT to omit sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer

2021 ◽  
Vol 32 ◽  
pp. S50
Author(s):  
E. Tanrikulu Simsek ◽  
E. Çoban ◽  
E. Atag ◽  
S. Gungor ◽  
M. Sarı ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Pet Ct ◽  
Fdg Pet Ct

Surgical Management of Sentinel Lymph Node Biopsy Outside Major Nodal Basin in Patients with Cutaneous Melanoma

2013 ◽  
Vol 21 (1) ◽  
pp. 300-305 ◽  
Author(s):  
Corrado Caracò ◽  
Ugo Marone ◽  
Gianluca Di Monta ◽  
Luigi Aloj ◽  
Corradina Caracò ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Surgical Management ◽  
Cutaneous Melanoma ◽  
Lymph Node Biopsy ◽  
Nodal Basin ◽  
Node Biopsy
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