ε-Poly-l-lysine as an efficient cartilage penetrating and residing drug carrier with high intraarticular injection safety for treating osteoarthritis

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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Review on SPG membrane emulsification: an efficient approach to prepare uniform microspheric drug carrier

MOJ Drug Design Development & Therapy ◽

10.15406/mojddt.2018.02.00036 ◽

2018 ◽

Vol 2 (3) ◽

Author(s):

Xiangling Gu

Keyword(s):

Drug Carrier ◽

Membrane Emulsification ◽

Efficient Approach ◽

Spg Membrane Emulsification

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The Role of Stent Design and Polymers in Safety Outcomes – A Review

European Cardiology Review ◽

10.15420/ecr.2012.8.1.63 ◽

2012 ◽

Vol 8 (1) ◽

pp. 63

Author(s):

Carlo Zivelonghi ◽

Giulia Geremia ◽

Michele Pighi ◽

Flavio Ribichini ◽

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...

Keyword(s):

Clinical Performance ◽

Drug Carrier ◽

Chemical Properties ◽

Vascular Wall ◽

Radial Force ◽

Vascular Trauma ◽

Polymer Composition ◽

Drug Eluting Stent ◽

Stent Design ◽

Drug Elution

Each component of a drug-eluting stent (DES) contributes to the safety of the device. Continuous efforts are being dedicated to the search of the optimal compromise between facility of use, safety and long-term efficacy. Shorter balloons reduce the vascular trauma beyond the stent struts; the metallic composition of the stent platform and the platform itself interact with the vascular wall in a long-lasting equilibrium between radial force, vessel patency and reparative cellular regrowth. The modality of drug elution is largely regulated by the chosen drug carrier, rather than by the chemical properties of the drug itself. Drug elution can be accomplished by permanent polymers that remain in the vessel wall forever, by biodegradable polymers that leave the naked metallic structure behind after their complete absorption, or even by direct release of the drug from stent reservoirs. The clinical performance of DESs has been exhaustively assessed in a large number of studies that have showed rapid and continuous improvements, from the first-generation DESs to the latest devices, based on substantial changes in stent design and polymer composition.

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