Nanoencapsulated chitosan nanoparticles in emulsion-based oral delivery system: In vitro and in vivo evaluation of insulin loaded formulation

2016 ◽  
Vol 36 ◽  
pp. 161-167 ◽  
Author(s):  
Gülşah Erel ◽  
Mustafa Kotmakçı ◽  
Hasan Akbaba ◽  
Sumru Sözer Karadağlı ◽  
Ayşe Gülten Kantarcı
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Chitosan Nanoparticles ◽  
In Vivo Evaluation ◽  
Oral Delivery System

In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan

Biomaterials ◽  
2006 ◽  
Vol 27 (23) ◽  
pp. 4250-4255 ◽  
Author(s):  
Florian Föger ◽  
Thierry Schmitz ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Oral Delivery System

Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo

2011 ◽  
Vol 420 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Liting Guo ◽  
Erli Ma ◽  
Haiwei Zhao ◽  
Yingfang Long ◽  
Changxue Zheng ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Preliminary Evaluation ◽  
Oral Delivery System

Thiolated chitosan: Development and in vivo evaluation of an oral delivery system for leuprolide

2012 ◽  
Vol 80 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Javed Iqbal ◽  
Gul Shahnaz ◽  
Glen Perera ◽  
Fabian Hintzen ◽  
Federica Sarti ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Oral Delivery System

Fenofibrate Solid Dispersion for Improving Oral Bioavailability: Preparation, and Characterization and in vivo Evaluation

2020 ◽  
Vol 13 (5) ◽  
pp. 5102-5109
Author(s):  
Venu Madhav K ◽  
Somnath De ◽  
Chandra Shekar Bonagiri ◽  
Sridhar Babu Gummadi
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Solid Dispersions ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
Scanning Calorimetry ◽  
In Vivo Evaluation

Fenofibrate (FN) is used in the treatment of hypercholesterolemia. It shows poor dissolution and poor oral bioavailability after oral administration due to high liphophilicity and low aqueous solubility. Hence, solid dispersions (SDs) of FN (FN-SDs) were develop that might enhance the dissolution and subsequently oral bioavailability. FN-SDs were prepared by solvent casting method using different carriers (PEG 4000, PEG 6000, β cyclodextrin and HP β cyclodextrin) in different proportions (0.25%, 0.5%, 0.75% and 1% w/v). FN-SDs were evaluated solubility, assay and in vitro release studies for the optimization of SD formulation. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) analysis was performed for crystalline and morphology analysis, respectively. Further, optimized FN-SD formulation evaluated for pharmacokinetic performance in Wistar rats, in vivo in comparison with FN suspension.  From the results, FN-SD3 and FN-SD6 have showed 102.9 ±1.3% and 105.5±3.1% drug release, respectively in 2 h. DSC and PXRD studies revealed that conversion of crystalline to amorphous nature of FN from FT-SD formulation. SEM studies revealed the change in the orientation of FN when incorporated in SDs. The oral bioavailability FN-SD3 and FN-SD6 formulations exhibited 2.5-folds and 3.1-folds improvement when compared to FN suspension as control. Overall, SD of FN could be considered as an alternative dosage form for the enhancement of oral delivery of poorly water-soluble FN.

A Novel Intravaginal Delivery System for Itraconazole: In Vitro and In Vivo Evaluation

2009 ◽  
Vol 6 (2) ◽  
pp. 151-158 ◽  
Author(s):  
N. Dobaria ◽  
R. Mashru ◽  
A. Badhan ◽  
A. Thakkar
Keyword(s):  
Delivery System ◽  
In Vivo Evaluation ◽  
Intravaginal Delivery
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