scholarly journals Proliferative retinopathy as a feature of Vogt Koyanagi Harada Disease: a report of two cases

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Moustafa S. Magliyah ◽  
Abdulmajeed S. Al-Fakhri ◽  
Hassan A. Al-Dhibi
Keyword(s):  
Fibrous Tissue ◽  
Proliferative Retinopathy ◽  
Tissue Formation ◽  
Immunomodulatory Agents ◽  
Case Presentation ◽  
Persistent Inflammation ◽  
Disc Area ◽  
Stable Vision ◽  
Pars Plana ◽  
Old Females

Abstract Background Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH. Case Presentation 19 and 33 years old females with VKH presented with unilateral proliferative retinopathy. Both patients had neovascularization of the optic disc (NVDs) and one patient had neovascularizations elsewhere (NVEs) and preretinal hemorrhage. Both patients had exudative retinal detachments (ERD). Systemic steroids and immunomodulatory agents were successfully used to control inflammation and achieve regression. One patient developed fibrous tissue formation at the disc area as well as an epiretinal membrane formation, for which she had pars plana vitrectomy with membrane peeling. Both patients had controlled inflammation with stable vision. Conclusions Proliferative retinopathy can present variably in VKH patients and indicates persistent inflammation which is incompletely controlled. Proper uveitis control is sufficient to achieve regression of retinal neovascularization.

scholarly journals Idiopathic Epiretinal Membrane in Young Patient: A Rare Case Presentation

2013 ◽  
Vol 52 (191) ◽  
Author(s):  
Raba Thapa ◽  
Govinda Paudyal
Keyword(s):  
Epiretinal Membrane ◽  
Fibrous Tissue ◽  
Young Patients ◽  
Retinal Diseases ◽  
Visual Recovery ◽  
Internal Layers ◽  
Case Presentation ◽  
Idiopathic Epiretinal Membrane ◽  
Pars Plana ◽  
One Year

Epiretinal membrane is avascular fibrous tissue which is adhered to the internal layers of retina in themacular area. Patient may be asymptomatic or present with blurring of vision and metamorphopsia.The idiopathic Epiretinal Membrane is more often seen in elderly but it could be present in youngpatients in association with other vitreo-retinal diseases and following intraocular surgery. Theidiopathic Eperetinal Membrane in young patients are rare. Here we present a thirty one year healthywomen presented with idiopathic Epiretinal Membrane who gained full visual recovery followingthe pars plana vitrectomy, membrane peeling and gas for its rarity._______________________________________________________________________________________Keywords: epiretinal membrane; idiopathic; young women.

IgG4-related autoimmune hepatitis with pathological characteristics of giant-cell hepatitis: A case report

2020 ◽  
Author(s):  
Tan You Wen ◽  
Jianhui Sheng ◽  
Xingbei Zhou
Keyword(s):  
Liver Function ◽  
Autoimmune Hepatitis ◽  
Giant Cell ◽  
Hepatitis A ◽  
Plasma Cells ◽  
Fibrous Tissue ◽  
Tissue Formation ◽  
Case Presentation ◽  
Portal Area ◽  
Giant Cell Hepatitis

Abstract Background ：Immunoglobulin (Ig)G4-positive plasma cells are thought to be present in some cases of autoimmune hepatitis (AIH), and giant-cell hepatitis (GCH) or synchronous giant hepatocytes are rare in some patients with AIH. Case presentation : A 68-year-old woman was hospitalized with asthenia, poor appetite, and yellow urine for more than 20 days. accompanied by obvious abnormal liver function, elevated IgG and IgG4 levels. Liver biopsy was performed, and the pathology showed extensive proliferation of fibrous tissue, formation of pseudolobules, moderate and severe interfacial inflammation, bridging necrosis and fibrosis, edema of hepatocytes as rosette-forming cells, multinucleated hepatocytes in each portal area, extensive monocyte lymph infiltration, dense plasma cells in the portal area, and positive plasma cells stained by IgG4 (more than 10 per portal area). The pathological diagnosis was IgG4-related AIH and GCH. Methylprednisolone was administered (20 mg/day). Two weeks later, her liver function gradually improved, and the immune indexes began to decline. Conclusion: we report a case of cirrhosis caused by AIH, which has the characteristics of IgG4 correlation and GCH in the hepatic pathology. Whether there is an inevitable relationship between them remains unclear.

Relaxin attenuates fibrous tissue formation

2001 ◽  
Vol 33 (6) ◽  
pp. A136
Author(s):  
Jiakun Zhang ◽  
Elaine N. Unemori ◽  
Yao Sun ◽  
Karl T. Weber
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation

In Vivo Monitoring of Osseointegration

2007 ◽  
Author(s):  
Lindsey R. VanSchoiack ◽  
Veronica I. Shubayev ◽  
Robert R. Myers ◽  
James C. Earthman
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation ◽  
Surgical Implant ◽  
In Vivo Monitoring

The process of osseointegration is the firm anchoring of a surgical implant by the growth of bone around it without fibrous tissue formation at the interface. This process is critical for long-term implant success. The ability to monitor this process in vivo would allow for personalization of loading protocols to increase the rate of implant success overall by ensuring that implants are not over or under loaded during recovery. Accordingly, there is a strong need for an instrument that has the sensitivity to noninvasively measure osseointegration in vivo. One of the objectives of the present study was to assess the performance of an instrumented percussion probe for quantitatively monitoring the osseointegration process.

New bone and fibrous tissue formation around ceramic cochlear implant receiver–stimulators and the measurement of their anchorage in the bony implant bed

2014 ◽  
Vol 15 (6) ◽  
pp. 327-332
Author(s):  
Robert Mlynski ◽  
Kristen Rak ◽  
Stefan Kaulitz ◽  
Fabian Kraus ◽  
Rudolf Hagen ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Fibrous Tissue ◽  
Tissue Formation ◽  
Implant Bed

THE INFLUENCE OF ADRENAL CORTICO-STEROIDS ON FIBROUS TISSUE FORMATION

1960 ◽  
Vol 240 (3) ◽  
pp. 387-395 ◽  
Author(s):  
ROGER W. REED ◽  
GARDNER C. MCMILLAN ◽  
KARL PINTAR
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation

Cluster endophthalmitis due to Stenotrophomonas maltophilia following intravitreal bevacizumab: outcomes of patients from North India

2018 ◽  
Vol 103 (9) ◽  
pp. 1278-1283 ◽  
Author(s):  
Aniruddha Kishandutt Agarwal ◽  
Kanika Aggarwal ◽  
Ramanuj Samanta ◽  
Archana Angrup ◽  
Manisha Biswal ◽  
...  
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Anterior Segment ◽  
Intravitreal Bevacizumab ◽  
North India ◽  
Positive Staining ◽  
Corrected Visual Acuity ◽  
Persistent Inflammation ◽  
Pars Plana ◽  
Toxic Anterior Segment Syndrome ◽  
Culture Positive

PurposeTo study features, management and outcomes of cluster endophthalmitis following intravitreal bevacizumab (BCZ) injection in North India.MethodsIn this retrospective study, 28 patients (23 men) (mean age of 59.07±13 years) who received intravitreal injection of BCZ were included. Demographic details, best corrected visual acuity (BCVA), clinical features, microbiological findings and management of patients who developed endophthalmitis after injection of contaminated BCZ injections were reviewed. The organism isolated was Stenotrophomonas maltophilia.ResultsAll patients suffered from painful diminution of vision within 24–48 hours. Of the 28 eyes, 12 had lid and corneal oedema, raised intraocular pressure (IOP) (difference between mean preinjection and postinjection IOP: 4.42 mm Hg; p=0.005) and toxic anterior segment syndrome-like picture. 16 eyes presented with clear cornea, severe vitritis and poor media clarity. Among these, three eyes showed posterior hypopyon. Seventeen eyes underwent primary pars plana vitrectomy (PPV) and intravitreal vancomycin+ceftazidime based on severity of inflammation. Eleven eyes underwent primary tap and inject. Among these, four eyes required PPV due to persistent inflammation. Eleven eyes showed positive staining for Gram-negative bacilli. Seven eyes were culture positive for S. maltophilia. Mean preinjection BCVA was 0.77±0.48. The first recorded postinjection BCVA was 2.52±0.82. BCVA (at 1 month) improved to 0.88±0.66.ConclusionsS. maltophilia can be found contaminating hospital surfaces and water supply. Early PPV, prompt intravitreal antibiotics and close communication with microbiologists greatly aided in salvaging all eyes from our cohort. Majority of the patients recovered their preinjection BCVA and IOP and achieved quiescence of inflammation.

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