Clinical Indications to Germectomy in Pediatric Dentistry: A Systematic Review

Germectomy is a procedure often required in patients at developmental age. It is defined as the surgical removal of the third molar at a very specific stage of development. The aim of this study was to systematically analyze the literature in terms of clinical indications for germectomy in patients at developmental age. Literature searches were performed using PubMed, Google Scholar, Cochrane Library and Scopus from 1952 to 30 June 2021. The study protocol was registered after the screening stage (PROSPERO CRD42021262949). The search strategy identified 3829 articles: 167 from PubMed, 2860 from Google Scholar, 799 from Cochrane Library and 3 from Scopus. Finally, eight full-text papers were included into the qualitative analysis. Based on the included studies, clinical indications for germectomy were mainly related to orthodontic causes, infectious and cariogenic causes and prophylaxis. Based on these results, it is not possible to present evidence-based clinical indications for germectomy in patients at developmental age. Clinical trials on this subject focused specifically on patients at developmental age are awaited.

Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation

CHO cell lines are a workhorse for the production of pharmaceutical proteins, but show some limitations in the variability and stability of N-glycosylation profiles. One promising approach to addressing this at the required systems-level is miRNA, which can regulate a large number of genes and have predictable targets. Herein, we first identified de novo 656 potential miRNAs in the CHO genome based on a combination of literature, database searching, and miRNA sequencing. We further sequenced mRNA from the same cultures, and used a combination of mRNA-miRNA correlation analysis, target prediction and literature searches to find miRNAs potentially targeting N-glycosylation. Our ten best miRNA candidates were subjected to miRNA overexpression, knockdown, or knock-out in CHO cell lines. Out of the ten candidates, four (miR-128, miR-34c, miR-30b, and miR-449a) showed positive effects on N-glycosylation and could be applied directly for CHO cell engineering. The fact that 40% of the screened targets had a desired effect, and the prediction of 656 miRNAs illustrates the massive potential of miRNA engineering in CHO.

Grandparenting, health, and well-being: a systematic literature review

Whether grandparenting is associated with improved health or well-being among older adults is a salient question in present-day aging societies. This systematic review compiles studies that consider the health or well-being outcomes of grandparenting, concerning (1) custodial grandparent families, where grandparents are raising grandchildren without parental presence; (2) three-generation households, where grandparents are living with adult children and grandchildren; and (3) non-coresiding grandparents, who are involved in the lives of their grandchildren. Review was based on literature searches conducted in September 2019 via Web of Science, PubMed, PsycINFO, and Ebsco. We screened 3868 abstracts across four databases, and by following the PRISMA guidelines, we identified 92 relevant articles (117 studies) that were published between 1978 and 2019. In 68% of cases, custodial grandparenting was associated with decreased health or well-being of grandparents. The few studies considering the health or well-being of grandparents living in three-generation households provided mixed findings (39% positive; 39% negative). Finally, in 69% of cases, involvement of non-coresiding grandparents was associated with improved grandparental outcomes; however, there was only limited support for the prediction that involved grandparenting being causally associated with grandparental health or well-being. Despite this, after different robustness checks (counting all nonsignificant results, taking into account the representativeness of the data and causal methodology), the main finding remains the same: the most negative results are found among custodial grandparents and three-generation households and most positive results among non-coresiding grandparents.

Pemimpin Idaman Dalam Masyarakat Multikultural

<p><em>This study aims to formulate indicators and characteristics of an effective leader and are desired by a multicultural society. This research is important to answer various problems or conflicts that occur in Indonesian society, especially social conflicts related to religion. Based on the existing literature, it is explained that the factors associated with effective multicultural leadership to deal with social conflict are personal identity, individual competence and individual experiences related to diversity. The method used in this article is through normative research or through literature searches such as books, journals, papers and other sources that are considered to be similar or relevant. The results of the research in this article indicate that factors related to multicultural leadership expected by society are one's innate nature, values that support diversity that are instilled early in a person and environmental factors that can provide experiences to increase cultural intelligence. In the indicators there are innate traits that are important to have, such as: patient, courageous, assertive and innovative.</em></p>

Animal Model for Glucocorticoid Induced Osteoporosis: A Systematic Review from 2011 to 2021

Clinical and experimental data have shown that prolonged exposure to GCs leads to bone loss and increases fracture risk. Special attention has been given to existing emerging drugs that can prevent and treat glucocorticoid-induced osteoporosis GIOP. However, there is no consensus about the most relevant animal model treatments on GIOP. In this systematic review, we aimed to examine animal models of GIOP centering on study design, drug dose, timing and size of the experimental groups, allocation concealment, and outcome measures. The present review was written according to the PRISMA 2020 statement. Literature searches were performed in the PubMed electronic database via Mesh with the publication date set between April, 2011, and February 2021. A total of 284 full-text articles were screened and 53 were analyzed. The most common animal species used to model GIOP were rats (66%) and mice (32%). In mice studies, males (58%) were preferred and genetically modified animals accounted for 28%. Our work calls for a standardization of the establishment of the GIOP animal model with better precision for model selection. A described reporting design, conduction, and selection of outcome measures are recommended.

Confidence and Hesitancy During the Early Roll-out of COVID-19 Vaccines Among Black, Hispanic, and Undocumented Immigrant Communities: a Review

Black and Hispanic Americans have been hardest hit with COVID-19 infections, hospitalizations, and deaths, yet during the first several months of vaccine roll-out they had the lowest level of vaccine uptake. Primarily, our research on vaccine hesitancy focused on skepticism around the vaccine itself and its roll-out. Our search strategy used PUBMED and Google with a prescribed set of definitions and search terms for two reasons: there were limited peer-reviewed studies during early period of roll-out and real-time perspectives were crucially needed. Literature searches occurred in April 2021and covered September 2020-April 2021. Analyses included expert opinion, survey results and qualitative summaries. Overall, for the general U.S. population, there was considerable hesitancy initially that remained high during the early roll-out. The general population expressed concerns over the speed of vaccine development (“warp speed”), confidence in the competence of government being involved in the development of vaccines and general mistrust of government. Among Black and Hispanic Americans, hesitancy was further expressed as mistrust in the medical establishment that was related to past and current medical mistreatment. Undocumented immigrants worried about access to insurance and possible deportation. These results on confidence in the vaccine early during vaccine roll-out suggest diverse reasons that influence a person’s decision to vaccinate or not. Additional barriers to vaccine uptake include complacency and access. To ensure health equity, particularly to address disparities in morbidity and mortality, vaccine hesitancy needs to be acknowledged and addressed as COVID-19 vaccine roll-out continues, and these observations calls for conscious planning to address these issues early with future health crises.

Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups

Prostate cancer is the second most common solid tumour in men worldwide and it is also the most common cancer affecting men of African descent. Prostate cancer incidence and mortality vary across regions and populations. Some of this is explained by a large heritable component of this disease. It has been established that men of African and African Caribbean ethnicity are predisposed to prostate cancer (PrCa) that can have an earlier onset and a more aggressive course, thereby leading to poorer outcomes for patients in this group. Literature searches were carried out using the PubMed, EMBASE and Cochrane Library databases to identify studies associated with PrCa risk and its association with ancestry, screening and management of PrCa. In order to be included, studies were required to be published in English in full-text form. An attractive approach is to identify high-risk groups and develop a targeted screening programme for them as the benefits of population-wide screening in PrCa using prostate-specific antigen (PSA) testing in general population screening have shown evidence of benefit; however, the harms are considered to weigh heavier because screening using PSA testing can lead to over-diagnosis and over-treatment. The aim of targeted screening of higher-risk groups identified by genetic risk stratification is to reduce over-diagnosis and treat those who are most likely to benefit.

ADA APA DENGAN INDUSTRI PERTAMBANGAN INDONESIA ? (Sebuah Tinjauan Singkat dari Sudut Pandang Makro Ekonomi)

This study was conducted to determine the benefits and role of the mining industry for the prosperity of Indonesia. In addition, this study also wants to know the contribution of mining to state and regional revenues. And finally, the purpose of this research is to find out the labor absorption capacity of the mining sector industry. This research is a literature research, which includes a study of the thoughts of several figures related to the mining industry. Equipped with empirical data from related agencies, as well as literature searches from various sources of information, interviews were also conducted with a number of parties from both government and private agencies. The information needed is related to the benefits, roles, absorption of labor, and the contribution of the mining industry to the state and region of Central Sulawesi Province. This research was conducted for three months, starting from September 2020 to November 2020 in Palu City, Central Sulawesi Province. The results of the study indicate that the existence of the mining industry in Indonesia can still provide the greatest benefit to the prosperity of the people. The mining industry's contribution to state revenues and mining-producing regions shows a positive trend. The absorption of labor in the mining sector will increase, especially local workers in line with the downstream policy of the mining sector. Keywords: Contribution, Industry, mining, welfare, labor

Socioeconomic and territorial dynamics in Breves-Marajó (Pa), post-decline of madeira activity

The present article aims to analyze the economy of the municipality of Breves, in Brazilian State of Pará, from the decline of logging activity, which was considered the main economic base of the city, linked to trade and service provision activities, as fundamental to the upkeep and subsistence of Breves’ population, and diversification of that production, against the decay of logging business. Such activities shape the local economy in our times, employing a considerable portion of Breves’ labor, including many of which were idle, because of the unemployment generated by the closing of timber companies. Aiming to broaden the discussion on the topic, it were conducted literature searches, as well as both qualitative and quantitative interviews, which contributed to the characterization of the local economy and to verify how the current economic activity is able to ensure the livelihood of the local population.