scholarly journals Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marianna Caterino ◽  
Monica Gelzo ◽  
Stefano Sol ◽  
Roberta Fedele ◽  
Anna Annunziata ◽  
...  
Keyword(s):  
Virus Entry ◽  
Critical Role ◽  
Membrane Vesicles ◽  
Virus Propagation ◽  
Lipidomic Analysis ◽  
Key Factor ◽  
Patient Profiles ◽  
Cellular Pathways ◽  
Severity Degree

AbstractIn recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets.

The essence of equity capital and its structuring for accounting needs

2017 ◽  
pp. 117-126
Author(s):  
Iryna Nazarova
Keyword(s):  
Accounting Standards ◽  
Financial Statements ◽  
Capital Allocation ◽  
Equity Capital ◽  
National Standards ◽  
Equity Structure ◽  
Key Factor ◽  
Business Property ◽  
Informational Value

The paper considers various interpretations of the essence of equity capital. The concept of equity capital is viewed from the perspective of property as a venture capital, i. e. business property, which does not guarantee profits and dividends, and for which there is no clear schedule of returning funds to investors and shareholders. The most common equity capital components in national and foreign practice are examined and compared. It is pointed out that the equity components mainly used in Ukraine are defined by the National Accounting Standards. Alternatively, the structure of equity capital components in foreign practice relies on the Conceptual Framework of Financial Statements, but it is further detailed by national standards of each country and depends on its policy and accounting characteristics. The structure of equity capital in foreign practice may be influenced by shareholders’ decisions on the establishment of funds (additional capital), allocation of profits, transactions with treasury shares. It is made clear that in most countries equity capital components include joint stock capital, surplus reserves, and retained profit. The article reviews the classification of equity capital, viewed as the key factor, and determines its influence on accounting principles and policies. It is concluded that in regulatory documents, there are no clear lines between types of equity capital. The paper also discusses various views of scholars on equity capital arrangement. It is found that in research works, equity capital is classified based on various characteristics, but the majority of researchers consider sources of equity capital to be the main criterion. In addition, there is no consensus among academics as to what types of equity capital can be singled out by the criterion described. Taking into consideration some proposals of scholars and foreign practice related to ac- counting of equity capital, the author develops a generalized structure of equity capital which is based on the sources of capital formation and includes: invested capital, particularly registered capital (statutory and mandatory share capital), corrective capital (unpaid and withdrawn capital), additional capital (capital received from investors for stock that exceeds the par value of the stock, i.e. additional equity capital); acquired capital (assets received for free, capital formed from revaluation of assets, other capital) and reinvested capital (retained profits (uncovered losses) and surplus reserves). The above equity structure can be used to prepare financial statements in order to increase its informational value. Proposals are given on how to improve methods for accounting of equity capital, in particular accounting of additional capital invested by founders in the account entitled “Non-registered investments of owners”.

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals A Possible Role of Copernicus Sentinel-2 Data to Support Common Agricultural Policy Controls in Agriculture

Agronomy ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 110
Author(s):  
Filippo Sarvia ◽  
Elena Xausa ◽  
Samuele De Petris ◽  
Gianluca Cantamessa ◽  
Enrico Borgogno-Mondino
Keyword(s):  
Agricultural Policy ◽  
Common Agricultural Policy ◽  
Observation Data ◽  
Key Factor ◽  
Ndvi Time Series ◽  
Earth Observation Data ◽  
Four Levels ◽  
Nw Italy ◽  
Sentinel 2

Farmers that intend to access Common Agricultural Policy (CAP) contributions must submit an application to the territorially competent Paying Agencies (PA). Agencies are called to verify consistency of CAP contributions requirements through ground campaigns. Recently, EU regulation (N. 746/2018) proposed an alternative methodology to control CAP applications based on Earth Observation data. Accordingly, this work was aimed at designing and implementing a prototype of service based on Copernicus Sentinel-2 (S2) data for the classification of soybean, corn, wheat, rice, and meadow crops. The approach relies on the classification of S2 NDVI time-series (TS) by “user-friendly” supervised classification algorithms: Minimum Distance (MD) and Random Forest (RF). The study area was located in the Vercelli province (NW Italy), which represents a strategic agricultural area in the Piemonte region. Crop classes separability proved to be a key factor during the classification process. Confusion matrices were generated with respect to ground checks (GCs); they showed a high Overall Accuracy (>80%) for both MD and RF approaches. With respect to MD and RF, a new raster layer was generated (hereinafter called Controls Map layer), mapping four levels of classification occurrences, useful for administrative procedures required by PA. The Control Map layer highlighted that only the eight percent of CAP 2019 applications appeared to be critical in terms of consistency between farmers’ declarations and classification results. Only for these ones, a GC was warmly suggested, while the 12% must be desirable and the 80% was not required. This information alone suggested that the proposed methodology is able to optimize GCs, making possible to focus ground checks on a limited number of fields, thus determining an economic saving for PA and/or a more effective strategy of controls.

scholarly journals CONCEPT OF TECHNOLOGICAL WAY AS MODERN CONTINUATION OF THEORY OF LONG CYCLES IN ECONOMY

2017 ◽  
Vol 2017 (1) ◽  
pp. 232-242 ◽  
Author(s):  
Александр Таранов ◽  
Aleksandr Taranov ◽  
Наталья Таранова ◽  
Natalya Taranova
Keyword(s):  
Long Waves ◽  
Technological Innovations ◽  
The Core ◽  
Technological Structure ◽  
Empirical Level ◽  
Key Factor ◽  
World Economic ◽  
Successive Change ◽  
Methodological Approaches

The paper reports the concept of a technological way as an urgent and empirically substantiated continuation of the wellknown theory of long waves in economy. The theory of long waves allows predicting on an empirical level world economic crises and an economic growth on the horizon for 50 years. The genesis of the theory of long waves by means of retrospective author’s classification of theories of long waves in accordance with technological, economic, institutional, administrative and social signs is analyzed. A basic range of authors having formed a modern and urgent theory of long waves which is verified by time and supported by empirical computations is presented by N.D. Kondratiev, G. Mensch, J. Dossy, Ch. Peres, S.Yu. Glaziev. The concept of a technological way being empirically confirmed by the continuation of the theory of long waves was formed by Academician Glaziev. In this concept there are revealed basic statement-laws and also the necessity of methodological approaches in technological, economic, institutional, administrative and sociological fields. The logic of the formation and interaction of technological totality is described thoroughly. The conclusions of technological way existence are drawn. Technological innovations defining the formation of the core of a technological way and revolutionizing a technological structure of economy have obtained a name of a “key factor”. Nanotechnologies are such a factor at present and for the prospect of 50 years. The conclusions of a basic property of a technological way being a self-reproducing integrity are drawn in consequence of which the technical development of economy cannot take place otherwise as by means of a successive change of technological ways.

scholarly journals Molecular Signaling and Cellular Pathways for Virus Entry

ISRN Virology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Pei-I Chi ◽  
Hung-Jen Liu
Keyword(s):  
Signaling Pathways ◽  
Viral Entry ◽  
Virus Entry ◽  
Host Cells ◽  
Target Cells ◽  
Molecular Signaling ◽  
Cellular Processes ◽  
Cellular Pathways ◽  
Host Life ◽  
Endocytic Vesicles

The cell signaling plays a pivotal role in regulating cellular processes and is often manipulated by viruses as they rely on the functions offered by cells for their propagation. The first stage of their host life is to pass the genetic materials into the cell. Although some viruses can directly penetrate into cytosol, in fact, most virus entry into their host cells is through endocytosis. This machinery initiates with cell type specific cellular signaling pathways, and the signaling compounds can be proteins, lipids, and carbohydrates. The activation can be triggered in a very short time after virus binds on target cells, such as receptors. The signaling pathways involved in regulation of viral entry are wide diversity that often cross-talk between different endocytosis results. Furthermore, some viruses have the ability to use the multiple internalization pathways which leads to the regulation being even more complex. In this paper, we discuss some recent advances in our understanding of cellular pathways for virus entry, molecular signaling during virus entry, formation of endocytic vesicles, and the traffic.

scholarly journals COVID-19 clinical implications: the significance of nanomedicine

Bioimpacts ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 137-138
Author(s):  
Jaleh Barar
Keyword(s):  
Quality Of Life ◽  
De Novo ◽  
Virus Entry ◽  
Therapeutic Strategies ◽  
Clinical Implications ◽  
Molecular Signaling ◽  
Key Factor ◽  
To Come

COVID-19 pandemic has profoundly affected the lives of humans worldwide. We no longer experience the same quality of life and need to come up with effective solutions to combat the clinical implications. The vast knowledge about the pathways that regulate the virus entry and molecular signaling of the pathogenesis of coronavirus are the key factor for the development of de novo diagnostic/therapeutic strategies. Meanwhile, the emergence of nanotechnology, could offer enormous help in the battle against coronavirus. In this editorial, the role of molecular elements in the pathobiology of the disease and the significance of nanoscaled pharmaceuticals is highlighted.

NEW CLASSIFICATION OF PRINCIPLES OF CIVIL PROCEDURE

2021 ◽  
Author(s):  
Тимур Султанович Габазов ◽  
Амир Ахметович Мужахаев ◽  
Аминат Аслановна Солтамурадова
Keyword(s):  
Civil Procedure ◽  
New Classification ◽  
Procedural Law ◽  
Civil Proceedings ◽  
Key Factor ◽  
The Subject ◽  
The Right

В представленной статье кратко раскрывается смысл понятия такого явления, как принцип гражданского процессуального права, а также дана классификация принципов, уже существующих и утвердившихся в теории гражданского процесса. Авторы работы предприняли попытку разработать новую классификацию принципов гражданского судопроизводства, отличную от общепринятой, в которой ключевым фактором выступает субъект, которому эти принципы адресованы по своему содержанию. По результатам проведенного исследования выделены субъекты, которым адресованы действия этих принципов: адресованные только суду; адресованные только лицам, участвующим в деле; - адресованные всем субъектам гражданского судопроизводства в целом (общие). Можно вполне обосновано сказать, что новая классификация принципов гражданского процесса, в зависимости от субъекта имеет право на существование. The presented article briefly reveals the meaning of the concept of such a phenomenon as the principle of civil procedural law, and also gives a classification of the principles that already exist and are established in the theory of civil procedure. The authors of the work attempted to develop a new classification of the principles of civil proceedings, different from the generally accepted one, in which the key factor is the subject to whom these principles are addressed in their content. According to the results of the study, the subjects to whom the actions of these principles are addressed: addressed only to the court; addressed only to persons participating in the case; - addressed to all subjects of civil proceedings in general (general). It can be reasonably said that the new classification of the principles of civil procedure, depending on the subject, has the right to exist.

scholarly journals Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy

2019 ◽  
Vol 20 (9) ◽  
pp. 2241 ◽  
Author(s):  
Debarati Banik ◽  
Sara Moufarrij ◽  
Alejandro Villagra
Keyword(s):  
Histone Deacetylase Inhibitors ◽  
Critical Role ◽  
Preclinical Studies ◽  
Clinical Use ◽  
Combination Therapies ◽  
Drug Candidates ◽  
Cellular Processes ◽  
Fda Approval

Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors (HDACis) have positioned these agents as promising drug candidates in combatting cancer, autoimmune, neurodegenerative, and infectious diseases. The same has also encouraged the evaluation of multiple HDACi candidates in preclinical studies in cancer and other diseases as well as the FDA-approval towards clinical use for specific agents. In this review, we have discussed how the efficacy of immunotherapy can be leveraged by combining it with HDACis. We have also included a brief overview of the classification of HDACis as well as their various roles in physiological and pathophysiological scenarios to target key cellular processes promoting the initiation, establishment, and progression of cancer. Given the critical role of the tumor microenvironment (TME) towards the outcome of anticancer therapies, we have also discussed the effect of HDACis on different components of the TME. We then have gradually progressed into examples of specific pan-HDACis, class I HDACi, and selective HDACis that either have been incorporated into clinical trials or show promising preclinical effects for future consideration. Finally, we have included examples of ongoing trials for each of the above categories of HDACis as standalone agents or in combination with immunotherapeutic approaches.

scholarly journals Ecological Sanitation and Sustainable Nutrient Recovery Education: Considering the Three Fixes for Environmental Problem-Solving

2020 ◽  
Vol 12 (9) ◽  
pp. 3587
Author(s):  
Julian Junghanns ◽  
Thomas Beery
Keyword(s):  
Higher Education ◽  
Nutrient Recycling ◽  
Critical Role ◽  
Engineering Programs ◽  
Ecological Sanitation ◽  
The United Kingdom ◽  
Extensive Coverage ◽  
Key Factor ◽  
Initial Hypothesis ◽  
Technological Transition

In the context of phosphorus as a finite resource and the unsustainable character of current sanitation in Europe, this paper examined social factors in a technological transition towards sustainable sanitation. The evaluation is based on the idea of cognitive, structural, and technological fixes to achieve environmental protection. The cognitive fix has been evaluated through literature and a European-wide survey with universities that offer civil and environmental engineering programs. Contrary to an initial hypothesis, ecological sanitation and nutrient recycling are taught by the majority (66%) of responding programs. There are, however, local differences in terms of context and detail of the education. The main impediments for teaching were identified as academic resources (especially in Belgium, Germany and Denmark) and the technological status quo (Ireland, Italy, Spain and some programs of the United Kingdom). Instructors’ personal commitment and experience was evaluated to be a key factor for an extensive coverage of sustainable sanitation in higher education programs. The role of higher education has a critical role to play in changing sanitation practices, given the unique professional developmental stage of students and the potential for a cognitive fix to contribute to meaningful change.

scholarly journals Comparison of Lake Optical Water Types Derived from Sentinel-2 and Sentinel-3

2019 ◽  
Vol 11 (23) ◽  
pp. 2883 ◽  
Author(s):  
Soomets ◽  
Uudeberg ◽  
Jakovels ◽  
Zagars ◽  
Reinart ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Lake Water ◽  
Natural Waters ◽  
Critical Role ◽  
Inland Waters ◽  
Water Types ◽  
Lake Võrtsjärv ◽  
Level 2 ◽  
Sentinel 2

Inland waters play a critical role in our drinking water supply. Additionally, they areimportant providers of food and recreation possibilities. Inland waters are known to be opticallycomplex and more diverse than marine or ocean waters. The optical properties of natural waters areinfluenced by three different and independent sources: phytoplankton, suspended matter, andcolored dissolved organic matter. Thus, the remote sensing of these waters is more challenging.Different types of waters need different approaches to obtain correct water quality products;therefore, the first step in remote sensing of lakes should be the classification of the water types. Theclassification of optical water types (OWTs) is based on the differences in the reflectance spectra ofthe lake water. This classification groups lake and coastal waters into five optical classes: Clear,Moderate, Turbid, Very Turbid, and Brown. We studied the OWTs in three different Latvian lakes:Burtnieks, Lubans, and Razna, and in a large Estonian lake, Lake Võrtsjärv. The primary goal of thisstudy was a comparison of two different Copernicus optical instrument data for opticalclassification in lakes: Ocean and Land Color Instrument (OLCI) on Sentinel-3 and MultispectralInstrument (MSI) on Sentinel-2. We found that both satellite OWT classifications in lakes werecomparable (R2 = 0.74). We were also able to study the spatial and temporal changes in the OWTs ofthe study lakes during 2017. The comparison between two satellites was carried out to understandif the classification of the OWTs with both satellites is compatible. Our results could give us not onlya better overview of the changes in the lake water by studying the temporal and spatial variabilityof the OWTs, but also possibly better retrieval of Level 2 satellite products when using OWT guidedapproach.

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