scholarly journals Acousto optic imaging beyond the acoustic diffraction limit using speckle decorrelation

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Daniel Doktofsky ◽  
Moriya Rosenfeld ◽  
Ori Katz
Keyword(s):  
Scattered Light ◽  
Super Resolution ◽  
Diffraction Limit ◽  
Resolution Limit ◽  
Contrast Imaging ◽  
Optical Contrast ◽  
Ultrasound Modulation ◽  
Wavefront Shaping ◽  
Acoustic Diffraction ◽  
Natural Dynamics

AbstractAcousto-optic imaging (AOI) enables optical-contrast imaging deep inside scattering samples via localized ultrasound modulation of scattered light. However, the resolution in AOI is inherently limited by the ultrasound focus size, prohibiting microscopic investigations. In recent years advances in the field of digital wavefront-shaping allowed the development of novel approaches for overcoming AOI’s acoustic resolution limit. However, these approaches require thousands of wavefront measurements within the sample speckle decorrelation time, limiting their application to static samples. Here, we show that it is possible to surpass the acoustic resolution-limit with a conventional AOI system by exploiting the natural dynamics of speckle decorrelations rather than trying to overcome them. We achieve this by adapting the principles of super-resolution optical fluctuations imaging (SOFI) to AOI. We show that naturally fluctuating optical speckle grains can serve in AOI as the analogues of blinking fluorophores in SOFI, enabling super-resolution by statistical analysis of fluctuating acousto-optic signals.

scholarly journals Current Development and Applications of Super-Resolution Ultrasound Imaging

Sensors ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2417
Author(s):  
Qiyang Chen ◽  
Hyeju Song ◽  
Jaesok Yu ◽  
Kang Kim
Keyword(s):  
Kidney Disease ◽  
Ultrasound Imaging ◽  
Atherosclerotic Plaque ◽  
Super Resolution ◽  
Emerging Technology ◽  
Diffraction Limit ◽  
Disease Models ◽  
Current Development ◽  
Future Directions ◽  
Acoustic Diffraction

Abnormal changes of the microvasculature are reported to be key evidence of the development of several critical diseases, including cancer, progressive kidney disease, and atherosclerotic plaque. Super-resolution ultrasound imaging is an emerging technology that can identify the microvasculature noninvasively, with unprecedented spatial resolution beyond the acoustic diffraction limit. Therefore, it is a promising approach for diagnosing and monitoring the development of diseases. In this review, we introduce current super-resolution ultrasound imaging approaches and their preclinical applications on different animals and disease models. Future directions and challenges to overcome for clinical translations are also discussed.

Pushing the super-resolution limit: recent improvements in microscopy below the diffraction limit

2021 ◽  
Author(s):  
D. J. Nieves ◽  
M. A. B. Baker
Keyword(s):  
Fluorescence Microscopy ◽  
Spatial Information ◽  
Biological Systems ◽  
Super Resolution ◽  
Diffraction Limit ◽  
Resolving Power ◽  
Resolution Limit ◽  
Single Protein ◽  
Super Resolution Microscopy ◽  
Near Future

Super-resolution microscopy has revolutionised the way we observe biological systems. These methods are now a staple of fluorescence microscopy. Researchers have used super-resolution methods in myriad systems to extract nanoscale spatial information on multiple interacting parts. These methods are continually being extended and reimagined to further push their resolving power and achieve truly single protein resolution. Here, we explore the most recent advances at the frontier of the ‘super-resolution’ limit and what opportunities remain for further improvements in the near future.

scholarly journals MINSTED fluorescence localization and nanoscopy

2021 ◽  
Author(s):  
Michael Weber ◽  
Marcel Leutenegger ◽  
Stefan Stoldt ◽  
Stefan Jakobs ◽  
Tiberiu S. Mihaila ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Super Resolution ◽  
Diffraction Limit ◽  
Stimulated Emission ◽  
Far Field ◽  
Inner Membrane ◽  
Mitochondrial Inner Membrane ◽  
Molecular Scale ◽  
Localization Precision ◽  
Super Resolution Microscopy

AbstractWe introduce MINSTED, a fluorophore localization and super-resolution microscopy concept based on stimulated emission depletion (STED) that provides spatial precision and resolution down to the molecular scale. In MINSTED, the intensity minimum of the STED doughnut, and hence the point of minimal STED, serves as a movable reference coordinate for fluorophore localization. As the STED rate, the background and the required number of fluorescence detections are low compared with most other STED microscopy and localization methods, MINSTED entails substantially less fluorophore bleaching. In our implementation, 200–1,000 detections per fluorophore provide a localization precision of 1–3 nm in standard deviation, which in conjunction with independent single fluorophore switching translates to a ~100-fold improvement in far-field microscopy resolution over the diffraction limit. The performance of MINSTED nanoscopy is demonstrated by imaging the distribution of Mic60 proteins in the mitochondrial inner membrane of human cells.

scholarly journals Microshape Measurement Method Using Speckle Interferometry Based on Phase Analysis

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 112
Author(s):  
Yasuhiko Arai
Keyword(s):  
Fine Structure ◽  
Phase Analysis ◽  
Measurement Method ◽  
Phase Distribution ◽  
Periodic Structures ◽  
Scattered Light ◽  
Speckle Interferometry ◽  
Diffraction Limit ◽  
Silica Microspheres ◽  
Measured Object

A method for the measurement of the shape of a fine structure beyond the diffraction limit based on speckle interferometry has been reported. In this paper, the mechanism for measuring the shape of the fine structure in speckle interferometry using scattered light as the illumination light is discussed. Furthermore, by analyzing the phase distribution of the scattered light from the surface of the measured object, this method can be used to measure the shapes of periodic structures and single silica microspheres beyond the diffraction limit.

Super-Resolution Restoration for Image Based on Entropy Constraint and Projection onto Convex Set

2012 ◽  
Vol 468-471 ◽  
pp. 1041-1048 ◽  
Author(s):  
Xiao Qin Li ◽  
Kang Ling Fang ◽  
Can Jin
Keyword(s):  
Convergence Rate ◽  
Millimeter Wave ◽  
Convex Set ◽  
Super Resolution ◽  
Reconstruction Algorithm ◽  
Spatial Domain ◽  
Imaging Systems ◽  
Resolution Limit ◽  
Classical Algorithm ◽  
Restoration Algorithm

Super-resolution reconstruction for image breaks through the resolution limit of imaging systems without hardware change. The algorithm of projection onto convex set (POCS) is a typical super-resolution reconstruction algorithm in spatial domain. The classical algorithm of POCS lacks the overall constraint for the image, and the convergence rate for iteration is incontrollable. A new super-resolution restoration algorithm for image based on entropy constraint and POCS is proposed in this paper, and experiments with optical and millimeter wave images demonstrate that the new algorithm is effective in improving the precision of super-resolution restoration.

scholarly journals Simulations of scattered light control algorithms for coronagraphic high contrast imaging

2003 ◽  
Author(s):  
Scott A. Basinger ◽  
Joseph J. Green ◽  
Stuart B. Shaklan ◽  
David C. Redding
Keyword(s):  
Scattered Light ◽  
Control Algorithms ◽  
High Contrast ◽  
Light Control ◽  
Contrast Imaging ◽  
High Contrast Imaging

Super-Resolution Readout for Magneto-Optical Disk by Optimizing the Deposition Condition of Non-Magnetic Mask Layer

2001 ◽  
Vol 674 ◽  
Author(s):  
Takayuki Shima ◽  
Johoo Kim ◽  
Hiroshi Fuji ◽  
Nobufumi Atoda ◽  
Junji Tominaga
Keyword(s):  
Silver Oxide ◽  
Near Field ◽  
Numerical Aperture ◽  
Super Resolution ◽  
Laser Wavelength ◽  
Deposition Condition ◽  
Resolution Limit ◽  
Plasma Sputtering ◽  
Mask Layer ◽  
Disk Structure

ABSTRACTSuper-resolution near-field structure (Super-RENS) was prepared by a heliconwave-plasma sputtering method to improve the disk property that is combined with a magneto-optical (MO) recording disk. Antimony and silver-oxide mask layers were prepared by the method and refractive indices were measured. Recording and retrieving of signals beyond the resolution limit (<370 nm) were achieved for both mask cases. Attempts to optimize the disk structure were also made using a conventional sputtering method. The smallest mark size was around 200 nm and the highest carrier-to-noise ratio (CNR) was 30 dB for 300-nm mark and 22 dB for 250-nm, when using a laser wavelength of 780 nm and a numerical aperture of 0.53. We have found that there is a competing super-resolutional mechanism besides Super-RENS that appears when high readout laser power is applied. This mechanism played rather an important role at least in the mark-size range of 200-370 nm.

scholarly journals Nonlinear wavefront engineering with metasurface decorated quartz crystal

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ningbin Mao ◽  
Yutao Tang ◽  
Mingke Jin ◽  
Guanqing Zhang ◽  
Yang Li ◽  
...  
Keyword(s):  
Quartz Crystal ◽  
Second Harmonic ◽  
Super Resolution ◽  
Optical Efficiency ◽  
The Past ◽  
Nonlinear Photonic Crystals ◽  
Resolution Imaging ◽  
Wavefront Shaping ◽  
Hybrid Platform ◽  
Light Generation

Abstract In linear optical processes, compact and effective wavefront shaping techniques have been developed with the artificially engineered materials and devices in the past decades. Recently, wavefront shaping of light at newly generated frequencies was also demonstrated using nonlinear photonic crystals and metasurfaces. However, the nonlinear wave-shaping devices with both high nonlinear optical efficiency and high wave shaping efficiency are difficult to realize. To circumvent this constraint, we propose the idea of metasurface decorated optical crystal to take the best aspects of both traditional nonlinear crystals and photonic metasurfaces. In the proof-of-concept experiment, we show that a silicon nitride metasurface decorated quartz crystal can be used for the wavefront shaping of the second harmonic waves generated in quartz. With this crystal-metasurface hybrid platform, the nonlinear vortex beam generation and nonlinear holography were successfully demonstrated. The proposed methodology may have important applications in nonlinear structured light generation, super-resolution imaging, and optical information processing, etc.

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