scholarly journals HETEROGENEITY OF THE CELLULAR IMMUNE RESPONSE

1971 ◽  
Vol 133 (2) ◽  
pp. 187-201 ◽  
Author(s):  
Robert C. Bast ◽  
Eleanor J. Manseau ◽  
Harold F. Dvorak
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Large Population ◽  
Specific Antigen ◽  
Lymphoid Cells ◽  
Lymphocyte Stimulation ◽  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Cellular Immune

Lymph node cells from guinea pigs immunized with HSA in complete Freund's adjuvant were grown in cultures containing different concentrations of specific antigen. Stimulation of thymidine incorporation was induced with progressively lower concentrations of HSA at successive intervals after sensitization. Moreover, the intensity of delayed skin reactions and the magnitude of stimulation in vitro increased over the same interval. These events are considered compatible with an evolution of the cellular immune response resulting from the selection of lymphoid cells by decreasing concentrations of antigen in vivo. Cells from animals rendered tolerant to HSA failed to respond to specific antigen in culture. As tolerance waned, stimulation was achieved at high but not low antigen concentrations. Tolerance, measured by cutaneous reactivity or by lymphocyte stimulation, was less readily induced in animals sensitized with adjuvant containing a reduced concentration of mycobacteria. Lymph nodes from these animals contained a large population of cells reactive at high antigen concentration, presumably less susceptible to the toleragenic effect of intravenous antigen. The dissociation of delayed hypersensitivity and antibody formation observed early in the immune response and upon recovery from tolerance has permitted correlation of lymphocyte stimulation with delayed hypersensitivity and cutaneous basophil hypersensitivity respectively.

scholarly journals Cellular immunity in chronic Chagas' disease

1977 ◽  
Vol 5 (4) ◽  
pp. 401-404
Author(s):  
O M Montufar ◽  
C C Musatti ◽  
E Mendes ◽  
N F Mendes
Keyword(s):  
Immune Response ◽  
Chagas Disease ◽  
Cellular Immunity ◽  
Cellular Immune Response ◽  
Specific Antigen ◽  
Lymphocyte Function ◽  
Cell Reactivity ◽  
Cellular Immune ◽  
Chronic Chagas Disease

The cellular immune response was assessed in 20 patients with chronic Chagas' disease (American trypanosomiasis). Thymus-derived lymphocyte function was determined in vivo by cutaneous reactivity to several antigens including a soluble preparation derived from Trypanosoma cruzi and sensitization to 2,4-dinitrochlorobenzene. The in vitro T-cell reactivity was investigated by the proliferative response to phytohemagglutinin and to T. cruzi antigen and by inhibition of leukocyte migration with the specific antigen. In addition, the proportion and absolute numbers of peripheral blood T and B-lymphocytes were determined by rosette formation. This research indicates that the general and specific cellular immune response, evaluated by the tests herein mentioned, is well preserved in patients, with Chagas' disease. We conclude that chronic Chagas' disease is not associated with deficiency in cellular immunity, nor does it lead to it. Conceivably, the active participation of delayed hypersensitivity may play an important role in the expression of the human chagasic lesions.

scholarly journals ANTIGEN RECOGNITION: IN VITRO STUDIES ON THE SPECIFICITY OF THE CELLULAR IMMUNE RESPONSE

1969 ◽  
Vol 130 (5) ◽  
pp. 1031-1045 ◽  
Author(s):  
Stuart F. Schlossman ◽  
Judith Herman ◽  
Arieh Yaron
Keyword(s):  
Immune Response ◽  
Lymph Node ◽  
Cellular Immune Response ◽  
Lymph Node Cell ◽  
Antigen Receptors ◽  
Lymph Node Cells ◽  
Cellular Immune ◽  
Conventional Antibody ◽  
Sensitive Population

Studies of the immunochemical specificity of antigen-induced thymidine-2-14C incorporation in lymph node cells obtained from animals immunized to a series of closely related α-DNP-oligolysines, ϵ-DNP-oligolysines, and oligolysines have shown that the sensitized cell exhibits an extraordinary degree of specificity for antigen. The sensitized cell is maximally stimulated by the homologous immunizing antigen and can discriminate among compounds which differ from one another only in the position of a dinitrophenyl group or D-lysine residue on an identical oligolysine backbone. These studies support the view that the immunogen is not degraded prior to the induction of the immune response, and that the majority of cells produced as a consequence of immunization have stereospecific antigen receptors for the DNP-oligolysine used to induce the response; a smaller and more variably sized population of cells is produced with receptors specific for the oligolysine portion of the immunizing antigen. When specifically sensitized lymph node cell cultures are stimulated in vitro by heterologous DNP-oligolysines, the oligolysine- and not the DNP-oligolysine-sensitive population of cells appears to play a crucial role in the specificity of such cross-reactions. It is concluded from these studies that the antigen receptor on the sensitized lymph node cell differs in both kind and degree from conventional antibody. The chemical nature of the receptor and the means by which this receptor reacts with antigen to initiate the biosynthetic or proliferative cellular immune response still remain undefined.

scholarly journals Suppression of in Vitro Cellular Immune Response by Nitrogen-Containing Terpene Alcohol Derivatives.

1996 ◽  
Vol 19 (11) ◽  
pp. 1443-1446 ◽  
Author(s):  
Yuji OKADA ◽  
Noriaki MATONO ◽  
Manzo SHIONO ◽  
Toshiyuki TAKAI ◽  
Masaki HIKIDA ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Cellular Immune
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