ORGAN ABSORBED DOSE ESTIMATION REFLECTING SPECIFIC ORGAN MASSES WITH SIMPLE SCALING OF REFERENCE DOSES USING THE ORGAN MASSES

2020 ◽  
Vol 189 (4) ◽  
pp. 489-496
Author(s):  
Kentaro Manabe ◽  
Shuji Koyama

Abstract Estimating organ absorbed doses in consideration of person-specific parameters is important for radiation protection in diagnostic nuclear medicine. This study proposes a straightforward method for estimating the organ dose that reflects a specific organ mass by scaling the reference organ dose using the inverse ratio of the specific organ mass to the reference organ mass. For the administration of radiopharmaceuticals labelled by 99mTc or 123I, the organ doses for the liver, spleen, red marrow and thyroid obtained by the method were compared with those generated by a Monte Carlo simulation. The discrepancies were less than 14% for the liver, spleen and thyroid. Conversely, in some cases, the red marrow discrepancies were greater than 30% due to the wide distribution of red marrow in the trunk and head regions. This study confirms that the method of scaling organ doses can be effective for estimating mass-specific doses for solid organs.

2020 ◽  
Vol 191 (1) ◽  
pp. 1-8
Author(s):  
W J Garzón ◽  
D F A Aldana ◽  
V F Cassola

Abstract The aim of this work was to estimate patient’s organ absorbed doses from pediatric helical head computed tomography (CT) examinations using the Size-Specific Dose Estimate (SSDE) methodology and to determine organ dose to SSDE conversion coefficients for clinical routine. Patient-specific organ and tissue absorbed doses from 139 Head CT scans performed in pediatric patients from 0 to 15 years old in a Public Hospital in Tunja, Colombia were estimated. The calculations were made through Monte Carlo simulations, based on patient-specific information, dosimetric CT quantities (CTDIvol, DLP) and age-specific computational human phantoms matched to patients on the basis of gender and size. SSDE showed to be a good quantity for estimate patient-specific organ doses from pediatric head CT examinations when appropriate phantom’s attenuation-based size metrics are chosen to match for any patient size. Strong correlations between absorbed dose and SSDE were found for skin (R2 = 0.99), brain (R2 = 0.98) and eyes (R2 = 0.97), respectively. Besides, a good correlation between SSDE and absorbed dose to the red bone marrow (tissue extended outside the scan coverage) was observed (R2 = 0.94). SSDE-to-organ-dose conversion coefficients obtained in this study provide a practical way to estimate patient-specific organ head CT doses.


2021 ◽  
Vol 60 (1) ◽  
pp. 93-113
Author(s):  
Nina Petoussi-Henss ◽  
Daiki Satoh ◽  
Helmut Schlattl ◽  
Maria Zankl ◽  
Vladimir Spielmann

AbstractThis article presents nuclide-specific organ dose rate coefficients for environmental external exposures due to soil contamination assumed as a planar source at a depth of 0.5 g cm−2 in the soil and submersion to contaminated air, for a pregnant female and its fetus at the 24th week of gestation. Furthermore, air kerma free-in-air coefficient rates are listed. The coefficients relate the organ equivalent dose rates (Sv s−1) to the activity concentration of environmental sources, in Bq m−2 or Bq m−3, allowing to time-integrate over a particular exposure period. The environmental radiation fields were simulated with the Monte Carlo radiation transport codes PHITS and YURI. Monoenergetic organ dose rate coefficients were calculated employing the Monte Carlo code EGSnrc simulating the photon transport in the voxel phantom of a pregnant female and fetus. Photons of initial energies of 0.015–10 MeV were considered including bremsstrahlung. By folding the monoenergetic dose coefficients with the nuclide decay data, nuclide-specific organ doses were obtained. The results of this work can be employed for estimating the doses from external exposures to pregnant women and their fetus, until more precise data are available which include coefficients obtained for phantoms at different stages of pregnancy.


2020 ◽  
Author(s):  
Ying Huang ◽  
Yang Yang ◽  
Xin Chen ◽  
Yiming Gao ◽  
Weihai Zhuo ◽  
...  

BACKGROUND CT imaging is one of the most important contributors to medical radiation exposure(1). The frequency of CT scans and radiation doses accepted by patients attracted serious concerns for health physics researchers. The utilization of advanced technology ATCM has the potentials to reduce CT radiation doses while diagnostic image quality is maintained (2-7). As ATCM adjusted tube currents slice by slice it brought challenges to organ dose estimation using conversion factors derived from fixed tube current. Cross-system communication with hospital Picture Archive and Communication System (PACS),made it possible to read massive data automatically like the scanning parameters of each slice in each case. Monte Carlo simulations are probably the most reliable techniques which could be used for accurate dose assessment. [8-11]. However, specific patient model development and specific patient dose simulations are computationally demanding and may require dedicated hardware resources, this limitation constrained its application in large scale investigation. As an alternative method, patient specific organ doses could be calculated using the patient specific scan parameters and the Monte Carlo simulated organ doses with reference human phantom, and then correct the results with patient size factors. Dw is referred as the preferred patient size metric that determined the patient group and affected organ dose. The distance of the pathway traversed by the X-ray beam could provide the best approximation of tissue length traversed during the examination (12, 13),as CT image is a cross-sectional map normalized to the linear attenuation of water (14). The purpose of current study was to establish a method to access patient-specific organ dose associated with ATCM in chest computed tomography (CT) scans by combining Monte Carlo simulation with parameters contracted from clinical CT images of each patient underwent chest CT scan with ATCM. OBJECTIVE To explore a method to access patient-specific organ dose associated with automatic tube current modulation (ATCM) in chest computed tomography (CT) scans based on the information extracted from PACS automatically. METHODS 176cases of chest CT scans were read through cross-system communication with hospital PACS. A total of 8468 images were collected and analyzed automatically using in-house software. The scanning parameters (kVp, tube current, collimation width, etc.) of each CT examination were collected in real time, and a middle CT image of each case was collected for patient size(water equivalent diameter, Dw) calculation. Based on the reference human phantom, organ doses were simulated slice by slice using Monte Carlo method. The patient specific organ doses were calculated by combining tube currents of each patient slice with the simulated results, and doses were revised by correction factors that related to patient size. RESULTS A sum of 8468 slice of tube currents were extracted and analyzed in this study, the average mAs for large size patient group was about 1.6 times to the small size patient group. For organs that covered in the scan range like lung, breast, heart, the dose values were 18.30±2.91mGy, 15.13 ±2.75mGy and 17.87±2.96mGy in small size patients(Dw smaller than 22cm).The dose values of lung, breast, heart, in medium-sized patients (Dw from 22cm to 25cm) were 21.89±4.60mGy, 18.16 ±4.13mGy and 21.46±4.60mGy, while the values were 24.98±4.40mGy, 20.81±3.66mGy and 24.77±4.46mGy respectively in large size patients(Dw larger than 25cm). The organ doses increase with the patient size due to the increase of mAs. CONCLUSIONS The PACS-based method of large batch organ dose calculation to patients undergoing chest CT with ATCM was established. The methods and results may provide guidance to the design and optimization of chest CT protocols with ATCM.


Author(s):  
Hassan Yousefnia ◽  
Samaneh Zolghadri ◽  
A. Reza Jalilian ◽  
Zohreh Naseri

AbstractAimThe amount of energy deposited on any organ by ionising radiation termedabsorbed dose, plays an important role in evaluating the risks associated with the administration of radiopharmaceuticals. In this research work, the absorbed dose received by human organs for153Sm-TTHMP and153Sm-PDTMP was evaluated based on biodistribution studies on the Syrian rats.Materials and methods153Sm-TTHMP and153Sm-PDTMP were successfully prepared with radiochemical purity of higher than 99%. The biodistribution of the complexes was investigated within the Syrian rats up to 48 hours post injection. The human absorbed dose of the complexes was estimated by the radiation dose assessment resource method.ResultsThe highest absorbed dose for153Sm-TTHMP and153Sm-PDTMP was observed in the trabecular bone with 1·085 and 1·826 mGy/MBq, respectively. The bone to other critical organ dose ratio for153Sm-PDTMP is significantly greater than153Sm-TTHMP. Also, the bone/red marrow dose ratio for these complexes is comparable with this ratio for153Sm-EDTMP, as the most clinically used Sm-153 bone pain palliative radiopharmaceutical.FindingsAccording to the considerable bone absorbed dose against the insignificant absorbed dose of non-target organs, these complexes can be used as potential bone pain palliative agents in clinical applications.


1989 ◽  
Vol 30 (2) ◽  
pp. 201-206 ◽  
Author(s):  
K. Geterud ◽  
A. Larsson ◽  
S. Mattsson

The radiation dose to patients and personnel was estimated during 11 percutaneous renal stone extractions. For the patients the energy imparted, the mean absorbed dose to various organs, and the effective dose equivalent were estimated. For different personnel categories some organ doses and the effective dose equivalent were also estimated. Large differences in the radiation dose between patients were observed. The mean effective dose equivalent to the patient was 4.2 (range 0.6–8.3) mSv, and the energy imparted 285 (range 50–500) mJ. These figures are comparable to those reported for routine colon examination and urography. For the personnel there were also large differences between individuals and categories. The highest radiation dose was received by the radiologist. It was estimated that a radiologist who performs 150 percutaneous renal stone extractions per year will receive a yearly contribution to his/her effective dose equivalent of 2.4 mSv. Even when the contribution from other diagnostic and interventional radiologic procedures is added, the total effective dose equivalent hardly exceeds 5 mSv or 1/10 of the present dose limit for persons engaged in radiologic work. For the hands of the radiologist there is a risk of doses closer to the present limit for single organs or tissues of 500 mSv/year.


Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2024 ◽  
Author(s):  
Bernhard Sattler ◽  
Mathias Kranz ◽  
Barbara Wenzel ◽  
Nalin T. Jain ◽  
Rareş-Petru Moldovan ◽  
...  

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolism with positron emission tomography (PET). Here, the organ doses (ODs) and the effective dose (ED) of the first 18F-labeled MCT1/MCT4 inhibitor were estimated in juvenile pigs. Whole-body dosimetry was performed in three piglets (age: ~6 weeks, weight: ~13–15 kg). The animals were anesthetized and subjected to sequential hybrid Positron Emission Tomography and Computed Tomography (PET/CT) up to 5 h after an intravenous (iv) injection of 156 ± 54 MBq [18F]FACH. All relevant organs were defined by volumes of interest. Exponential curves were fitted to the time–activity data. Time and mass scales were adapted to the human order of magnitude and the ODs calculated using the ICRP 89 adult male phantom with OLINDA 2.1. The ED was calculated using tissue weighting factors as published in Publication 103 of the International Commission of Radiation Protection (ICRP103). The highest organ dose was received by the urinary bladder (62.6 ± 28.9 µSv/MBq), followed by the gall bladder (50.4 ± 37.5 µSv/MBq) and the pancreas (30.5 ± 27.3 µSv/MBq). The highest contribution to the ED was by the urinary bladder (2.5 ± 1.1 µSv/MBq), followed by the red marrow (1.7 ± 0.3 µSv/MBq) and the stomach (1.3 ± 0.4 µSv/MBq). According to this preclinical analysis, the ED to humans is 12.4 µSv/MBq when applying the ICRP103 tissue weighting factors. Taking into account that preclinical dosimetry underestimates the dose to humans by up to 40%, the conversion factor applied for estimation of the ED to humans would rise to 20.6 µSv/MBq. In this case, the ED to humans upon an iv application of ~300 MBq [18F]FACH would be about 6.2 mSv. This risk assessment encourages the translation of [18F]FACH into clinical study phases and the further investigation of its potential as a clinical tool for cancer imaging with PET.


2020 ◽  
Vol 189 (4) ◽  
pp. 407-419
Author(s):  
Haowei Zhang ◽  
Si Sun ◽  
Heqing Lu ◽  
Ying Liu

Abstract The purpose of this study is to construct boundary representation (BREP) phantom for Chinese women of childbearing age, to estimate the external radiation dose and to analyze radiation protection scheme. The BREP phantom for Chinese women of childbearing age was constructed by image segmentation, 3D reconstruction, non-uniform rational B-spline surface construction and voxelization. The photon-irradiated organ absorbed dose-conversion coefficients (DCCK) of the three female specific organs and the photon effective dose-conversion coefficient (ECCK) were calculated by Monte-Carlo method. The results showed that age, body fat-tissue thickness, direction and area of irradiation, organ location and volume all affected the dose of women specific organs when receiving medical exposure. In the case of ensuring the quality of the diagnosis, radiation protection for female specific organs can be achieved by organ dose modulation techniques and reducing exposure area or volume.


2020 ◽  
Vol 189 (4) ◽  
pp. 475-488
Author(s):  
Peter H Pedersen ◽  
Asger G Petersen ◽  
Svend E Ostgaard ◽  
Torben Tvedebrink ◽  
Søren P Eiskjær

Abstract This study evaluated repeated mean organ dose measurements of the liver by phantom dosimetry and statistical modelling in order to find a way to reduce the number of dosemeters needed for precise organ dose measurements. Thermoluminescent dosemeters were used in an adult female phantom exposed to a biplanar x-ray source at three different axial phantom rotations. Generalised mixed linear effect modelling was used for statistical analysis. A subgroup of five to six organ-specific locations out of 28 yielded mean liver organ doses within 95% confidence intervals of measurements based on all 28 liver-specific dosemeter locations. No statistical difference of mean liver dose was observed with rotation of the phantom either 10° clockwise or counter-clockwise as opposed to the coronal plane. Phantom dosimetry handling time during organ dose measurements can be markedly reduced, in this case the liver, by 79% (22/28), while still providing precise mean organ dose measurements.


2019 ◽  
Vol 26 (2) ◽  
pp. 517-527
Author(s):  
Stewart Midgley ◽  
Nanette Schleich ◽  
Alex Merchant ◽  
Andrew Stevenson

The dose length product (DLP) method for medical computed tomography (CT) dosimetry is applied on the Australian Synchrotron Imaging and Medical Beamline (IMBL). Beam quality is assessed from copper transmission measurements using image receptors, finding near 100% (20 keV), 3.3% (25 keV) and 0.5% (30–40 keV) relative contributions from third-harmonic radiation. The flat-panel-array medical image receptor is found to have a non-linear dose response curve. The amount of radiation delivered during an axial CT scan is measured as the dose in air alone, and inside cylindrical PMMA phantoms with diameters 35–160 mm for mono-energetic radiation 25–100 keV. The radiation output rate for the IMBL is comparable with that used for medical CT. Results are presented as the ratios of CT dose indices (CTDI) inside phantoms to in air with no phantom. Ratios are compared for the IMBL against medical CT where bow-tie filters shape the beam profile to reduce the absorbed dose to surface organs. CTDI ratios scale measurements in air to estimate the volumetric CTDI representing the average dose per unit length, and the dose length product representing the absorbed dose to the scanned volume. Medical CT dose calculators use the DLP, beam quality, axial collimation and helical pitch to estimate organ doses and the effective dose. The effective dose per unit DLP for medical CT is presented as a function of body region, beam energy and sample sizes from neonate to adult.


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