scholarly journals The genetics of Bene Israel from India reveals both substantial Jewish and Indian ancestry

2015 ◽  
Author(s):  
Yedael Y. Waldman ◽  
Arjun Biddanda ◽  
Natalie R. Davidson ◽  
Paul Billing-Ross ◽  
Maya Dubrovsky ◽  
...  
Keyword(s):  
Arrival Time ◽  
Middle Eastern ◽  
Principal Component ◽  
Genome Wide ◽  
History Of ◽  
Admixed Population ◽  
Bene Israel ◽  
Admixture Linkage Disequilibrium ◽  
Jewish Populations ◽  
Do So

AbstractThe Bene Israel Jewish community from West India is a unique population whose history before the 18th century remains largely unknown. Bene Israel members consider themselves as descendants of Jews, yet the identity of Jewish ancestors and their arrival time to India are unknown, with speculations on arrival time varying between the 8th century BCE and the 6th century CE. Here, we characterize the genetic history of Bene Israel by collecting and genotyping 18 Bene Israel individuals. Combining with 486 individuals from 41 other Jewish, Indian and Pakistani populations, and additional individuals from worldwide populations, we conducted comprehensive genome-wide analyses based on FST, principal component analysis, ADMIXTURE, identity-by-descent sharing, admixture linkage disequilibrium decay, haplotype sharing and allele sharing autocorrelation decay, as well as contrasted patterns between the X chromosome and the autosomes. The genetics of Bene Israel individuals resemble local Indian populations, while at the same time constituting a clearly separated and unique population in India. They are unique among Indian and Pakistani populations we analyzed in sharing considerable genetic ancestry with other Jewish populations. Putting together the results from all analyses point to Bene Israel being an admixed population with both Jewish and Indian ancestry, with the genetic contribution of each of these ancestral populations being substantial. The admixture took place in the last millennium, about 19-33 generations ago. It involved Middle-Eastern Jews and was sex-biased, with more male Jewish and local female contribution. It was followed by a population bottleneck and high endogamy, which can lead to increased prevalence of recessive diseases in this population. This study provides an example of how genetic analysis advances our knowledge of human history in cases where other disciplines lack the relevant data to do so.

scholarly journals Genetic affinities of the Jewish populations of India

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Gyaneshwer Chaubey ◽  
Manvendra Singh ◽  
Niraj Rai ◽  
Mini Kariappa ◽  
Kamayani Singh ◽  
...  
Keyword(s):  
Middle Eastern ◽  
Large Sample Size ◽  
Indian Populations ◽  
Jewish Diaspora ◽  
Jewish Migration ◽  
Shared Ancestry ◽  
History Of ◽  
Other World ◽  
A Minor ◽  
Jewish Populations

Abstract Due to the lack of written records or inscription, the origin and affiliation of Indian Jewish populations with other world populations remain contentious. Previous genetic studies have found evidence for a minor shared ancestry of Indian Jewish with Middle Eastern (Jewish) populations. However, these studies (relied on limited individuals), haven’t explored the detailed temporal and spatial admixture process of Indian Jewish populations with the local Indian populations. Here, using large sample size with combination of high resolution biparental (autosomal) and uniparental markers (Y chromosome and mitochondrial DNA), we reconstructed genetic history of Indian Jewish by investigating the patterns of genetic diversity. Consistent with the previous observations, we detected minor Middle Eastern specific ancestry component among Indian Jewish communities, but virtually negligible in their local neighbouring Indian populations. The temporal test of admixture suggested that the first admixture of migrant Jewish populations from Middle East to South India (Cochin) occurred during fifth century. Overall, we concluded that the Jewish migration and admixture in India left a record in their genomes, which can link them to the ‘Jewish Diaspora’.

scholarly journals Extreme Genomic Makeover: Evolutionary History of Maternally-transmitted Clam Symbionts

2020 ◽  
Author(s):  
M Perez ◽  
C Breusing ◽  
B Angers ◽  
YJ Won ◽  
CR Young
Keyword(s):  
Genome Evolution ◽  
Evolutionary History ◽  
Free Living ◽  
Genome Wide ◽  
A Genome ◽  
Chemosynthetic Bacteria ◽  
History Of ◽  
Vesicomyid Clam ◽  
Do So

AbstractGiven their recent switch to a vertically-transmitted intracellular lifestyle, the chemosynthetic bacteria associated with deep-sea vesicomyid clams are an excellent model system to study the processes underlying reductive genome evolution. In this study, we provide the first estimates of the relative contributions of drift, recombination and selection in shaping the ongoing reductive genome evolution in these symbionts. To do so, we compared the genomes of endosymbionts associated with 11 vesicomyid clam species to that of closely related free-living bacteria and their respective hosts’ mitochondria. Our investigation confirmed that neutral evolutionary processes were the dominant driver of reductive genome evolution in this group and highlighted the important role of horizontal gene transfer in mitigating genome erosion. Finally, a genome-wide screen for episodic positive selection across the symbiont phylogeny revealed the pervasive role of selective processes in maintaining symbiont functional integrity.

Conclusion

2018 ◽  
Author(s):  
Stefan Winter
Keyword(s):  
Middle Eastern ◽  
Rich Diversity ◽  
The Social ◽  
Local Contexts ◽  
History Of ◽  
Religious Oppression ◽  
The Rich ◽  
To Come

This concluding chapter summarizes key themes and presents some final thoughts. The book has shown that the multiplicity of lived ʻAlawi experiences cannot be reduced to the sole question of religion or framed within a monolithic narrative of persecution; that the very attempt to outline a single coherent history of “the ʻAlawis” may indeed be misguided. The sources on which this study has drawn are considerably more accessible, and the social and administrative realities they reflect consistently more mundane and disjointed, than the discourse of the ʻAlawis' supposed exceptionalism would lead one to believe. Therefore, the challenge for historians of ʻAlawi society in Syria and elsewhere is not to use the specific events and structures these sources detail to merely add to the already existing metanarratives of religious oppression, Ottoman misrule, and national resistance but rather to come to a newer and more intricate understanding of that community, and its place in wider Middle Eastern society, by investigating the lives of individual ʻAlawi (and other) actors within the rich diversity of local contexts these sources reveal.

Home, Sweet Home: Negotiating Intimacy in Brazilian Elitist Closed Condominiums

2020 ◽  
Vol 9 (1) ◽  
pp. 374-395
Author(s):  
Rafael Ignacio Estrada Mejia ◽  
Carla Guerrón Guerron Montero
Keyword(s):  
Collective Mode ◽  
Living Arrangement ◽  
Public Life ◽  
Ethnographic Research ◽  
Social Distinction ◽  
History Of ◽  
Collective Production ◽  
The Relationship ◽  
Do So

This article aims to decrease the cultural invisibility of the wealthy by exploring the Brazilian emergent elites and their preferred living arrangement: elitist closed condominiums (BECCs) from a micropolitical perspective.  We answer the question: What is the relationship between intimacy and subjectivity that is produced in the collective mode of existence of BECCs? To do so, we trace the history of the elite home, from the master’s house (casa grande) to contemporary closed condominiums. Following, we discuss the features of closed condominiums as spaces of segregation, fragmentation and social distinction, characterized by minimal public life and an internalized sociability. Finally, based on ethnographic research conducted in the mid-size city of Londrina (state of Paraná) between 2015 and 2017, we concentrate on four members of the emergent elite who live in BECCs, addressing their collective production of subjectivity. 

The Fall of Tripoli in 1289 in the Perception of Christian Communities of the Middle East

2020 ◽  
Author(s):  
К.А. Панченко
Keyword(s):  
Educational Level ◽  
Historical Memory ◽  
Middle Eastern ◽  
Political Orientation ◽  
13Th Century ◽  
Christian Communities ◽  
The Past ◽  
History Of ◽  
Modern Era ◽  
Religious Polemics

Abstract The article examines the conquest of the County of Tripoli by the Mamelukes in 1289, and the reaction of various Middle Eastern ethnoreligious groups to this event. Along with the Monophysite perspective (the Syriac chronicle of Bar Hebraeus’ Continuator and the work of the Coptic historian Mufaddal ibn Abi-l-Fadail), and the propagandist texts of Muslim Arabic panegyric poets, we will pay special attention to the historical memory of the Orthodox (Melkite) and Maronite communities of northern Lebanon. The contemporary of these events — the Orthodox author Suleiman al-Ashluhi, a native of one of the villages of the Akkar Plateau — laments the fall of Tripoli in his rhymed eulogy. It is noteworthy that this author belongs to the rural Melkite subculture, which — in spite of its conservative character — was capable of producing original literature. Suleiman al-Ashluhi’s work was forsaken by the following generations of Melkites; his poem was only preserved in Maronite manuscripts. Maronite historical memory is just as fragmented. The father of the Modern Era Maronite historiography — Gabriel ibn al-Qilaʿî († 1516) only had fragmentary information on the history of his people in the 13th century: local chronicles and the heroic epos that glorified the Maronite struggle against the Muslim lords that tried to conquer Mount Lebanon. Gabriel’s depiction of the past is not only biased and subject to aims of religious polemics, but also factually inaccurate. Nevertheless, the texts of Suleiman al-Ashluhi and Gabriel ibn al-Qilaʿî give us the opportunity to draw conclusions on the worldview, educational level, political orientation and peculiar traits of the historical memory of various Christian communities of Mount Lebanon.

The Birth of the Prophet Muhammad

2009 ◽  
Vol 26 (1) ◽  
pp. 97-99
Author(s):  
Frederick S. Colby
Keyword(s):  
Twentieth Century ◽  
Middle Eastern ◽  
Formative Period ◽  
Central Importance ◽  
Islamic Studies ◽  
Critical Scholarship ◽  
History Of ◽  
Late Twentieth ◽  
Modern Era ◽  
Late Twentieth Century

Despite the central importance of festival and devotional piety to premodernMuslims, book-length studies in this field have been relatively rare.Katz’s work, The Birth of the Prophet Muhammad, represents a tour-deforceof critical scholarship that advances the field significantly both throughits engagement with textual sources from the formative period to the presentand through its judicious use of theoretical tools to analyze this material. Asits title suggests, the work strives to explore how Muslims have alternativelypromoted and contested the commemoration of the Prophet’s birth atdifferent points in history, with a particular emphasis on how the devotionalistapproach, which was prominent in the pre-modern era, fell out of favoramong Middle Eastern Sunnis in the late twentieth century. Aimed primarilyat specialists in Middle Eastern and Islamic studies, especially scholarsof history, law, and religion, this work is recommended to anyone interestedin the history of Muslim ritual, the history of devotion to the Prophet, andthe interplay between normative and non-normative forms ofMuslim beliefand practice ...

The burden of cardiovascular disease risk factors in the Middle East: A systematic review and meta-analysis focusing on primary prevention

2020 ◽  
Vol 18 ◽  
Author(s):  
Akshaya Srikanth Bhagavathula ◽  
Abdullah Shehab ◽  
Anhar Ullah ◽  
Jamal Rahmani
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Disease ◽  
Family History ◽  
Primary Prevention ◽  
Middle East ◽  
Disease Risk ◽  
Meta Analysis ◽  
Middle Eastern ◽  
History Of

Background: The increasing incidence of cardiovascular disease (CVD) threatens the Middle Eastern population. Several epidemiological studies have assessed CVD and its risk factors in terms of the primary prevention of CVD in the Middle East. Therefore, summarizing the information from these studies is essential. Aim: We conducted a systematic review to assess the prevalence of CVD and its major risk factors among Middle Eastern adults based on the literature published between January 1, 2012 and December 31, 2018 and carried out a meta-analysis. Methods: We searched electronic databases such as PubMed/Medline, ScienceDirect, Embase and Google Scholar to identify literature published from January 1, 2012 to December 31, 2018. All the original articles that investigated the prevalence of CVD and reported at least one of the following factors were included: hypertension, diabetes, dyslipidaemia, smoking and family history of CVD. To summarize CVD prevalence, we performed a random-effects meta-analysis. Results: A total of 41 potentially relevant articles were included, and 32 were included in the meta-analysis (n=191,979). The overall prevalence of CVD was 10.1% (95% confidence interval (CI): 7.1-14.3%, p<0.001) in the Middle East. A high prevalence of CVD risk factors, such as dyslipidaemia (43.3%; 95% CI: 21.5-68%), hypertension (26.2%; 95% CI: 19.6-34%) and diabetes (16%; 95% CI: 9.9-24.8%), was observed. The prevalence rates of other risk factors, such as smoking (12.4%; 95% CI: 7.7-19.4%) and family history of CVD (18.7%; 95% CI: 15.4-22.5%), were also high. Conclusion: The prevalence of CVD is high (10.1%) in the Middle East. The burden of dyslipidaemia (43.3%) in this region is twice as high as that of hypertension (26.2%) and diabetes mellitus (16%). Multifaceted interventions are urgently needed for the primary prevention of CVD in this region.

De splitsing van de Belgische Socialistische Partij. Twee verklarende documenten

2008 ◽  
Vol 67 (2) ◽  
pp. 99-114
Author(s):  
Pieter-Jan Van Bosstraeten
Keyword(s):  
Socialist Party ◽  
French Speaking ◽  
History Of ◽  
Post War ◽  
Shed Light ◽  
Do So

Op 11 oktober 1978 splitste de Belgische Socialistische Partij zich als laatste van de drie unitaire partijen op in twee autonome partijen. Langs Franstalige zijde werd éénzijdig de Parti Socialiste opgericht, twee jaar later volgde de Socialistische Partij. De splitsing vormde het eindpunt van een lange en bewogen geschiedenis van de socialistische eenheidspartij.Ondanks het feit dat heel wat auteurs reeds een licht hebben geworpen op de belangrijkste gebeurtenis uit de na-oorlogse geschiedenis van de BSP, is het antwoord op de vraag naar de oorzaken van de splitsing vrij eenduidig. Overwegend wordt aangenomen dat de splitsing van de BSP het gevolg is van een moeilijke samenwerking in het kader van het communautaire dossier. Andere oorzaken worden amper aangehaald, of onvoldoende verduidelijkt. Tevens wordt slechts het politiek-tactische aspect van het communautaire dossier uitvoerig besproken. In de bestaande literatuur wordt zo goed als nergens dieper ingegaan op de inhoudelijke elementen die binnen de partij problemen teweegbrachten.Onderzoek van twee cruciale documenten heeft de mogelijkheid geboden het verhaal van de splitsing beter te reconstrueren. Daarbij is gebleken dat de splitsing van de partij in een ruimer kader dient te worden geïnterpreteerd dan het communautaire dossier. Aan de splitsing van de partij ging een lang proces van autonomisering en vleugelvorming vooraf. Bovendien werd aangetoond dat de problematiek inzake het Egmont-Stuyvenbergpact niet de enige directe oorzaak vormde voor de splitsing van de partij, in de periode 1977-1978. Enkele andere oorzaken hebben daartoe eveneens bijgedragen.________The division of the Belgian Socialist Party. Two explanatory documentsOn 11 October 1978 the Belgian Socialist Party divided into two autonomous parties, the last of the three unitary parties to do so. First the French speaking section unilaterally founded the ‘Parti Socialiste’, two years later the ‘Socialistische Partij’ followed. The division constituted the termination of the long and eventful history of the socialist unitary party.In spite of the fact that many authors have already shed light on the most important event from the post-war history of the BSP, the answer to the question about the causes for the division are fairly unequivocal. The majority of opinions favour the view that the division of the BSP was the consequence of the difficulty of collaborating within the framework of the community dossier. Other causes are hardly cited, or insufficiently elucidated. Moreover only the politico-tactical aspect of the community dossier is discussed in detail. The existing literature hardly ever carries out a more thorough examination of the intrinsic elements that caused problems within the party.The investigation of the two crucial documents has offered the opportunity to provide a better reconstruction of the division. This showed that the division of the party should be interpreted within a larger framework than the community dossier alone. A long process of autonomisation and the formation of political wings preceded the division of the party. It also demonstrated that the issues concerning the Egmont-Stuyvenberg pact were not the only direct cause for the division of the party, during the period 1977-1978. There were several other causes that also contributed to this division.

Emotional Cities

2017 ◽  
Author(s):  
Joseph Ben Prestel
Keyword(s):  
Nineteenth Century ◽  
Capital Flows ◽  
Urban History ◽  
Middle Eastern ◽  
Loss Of Control ◽  
Global Capital ◽  
Dynamic Transformation ◽  
Two Cities ◽  
History Of ◽  
The City

Between 1860 and 1910, Berlin and Cairo went through a period of dynamic transformation. During this period, a growing number of contemporaries in both places made corresponding arguments about how urban change affected city dwellers’ emotions. In newspaper articles, scientific treatises, and pamphlets, shifting practices, such as nighttime leisure, were depicted as affecting feelings like love and disgust. Looking at the ways in which different urban dwellers, from psychologists to revelers, framed recent changes in terms of emotions, this book reveals the striking parallels between the histories of Berlin and Cairo. In both cities, various authors associated changes in the city with such phenomena as a loss of control over feelings or the need for a reform of emotions. The parallels in these arguments belie the assumed dissimilarity between European and Middle Eastern cities during the nineteenth century. Drawing on similar debates about emotions in Berlin and Cairo, the book provides a new argument about the regional compartmentalization of urban history. It highlights how the circulation of scientific knowledge, the expansion of empires, and global capital flows led to similarities in the pasts of these two cities. By combining urban history and the history of emotions, this book proposes an innovative perspective on the emergence of different, yet comparable cities at the end of the nineteenth century.

scholarly journals Variation in VKORC1 Is Associated with Vascular Dementia

2021 ◽  
Vol 80 (3) ◽  
pp. 1329-1337
Author(s):  
Jure Mur ◽  
Daniel L. McCartney ◽  
Daniel I. Chasman ◽  
Peter M. Visscher ◽  
Graciela Muniz-Terrera ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vascular Dementia ◽  
Genetic Variant ◽  
Warfarin Dose ◽  
Uk Biobank ◽  
Parental History ◽  
Genome Wide ◽  
History Of ◽  
First Time ◽  
The Relationship

Background: The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10–7), which was included in the genome-wide significant KAT8 locus. Objective: Our study aimed to investigate whether the relationship between rs9923231 and dementia persists only for certain dementia sub-types, and if those taking warfarin are at greater risk. Methods: We used logistic regression and data from 238,195 participants from UK Biobank to examine the relationship between VKORC1, risk of dementia, and the interplay with warfarin use. Results: Parental history of dementia, APOE variant, atrial fibrillation, diabetes, hypertension, and hypercholesterolemia all had strong associations with vascular dementia (p < 4.6×10–6). The T-allele in rs9923231 was linked to a lower warfarin dose (βperT - allele = –0.29, p < 2×10–16) and risk of vascular dementia (OR = 1.17, p = 0.010), but not other dementia sub-types. However, the risk of vascular dementia was not affected by warfarin use in carriers of the T-allele. Conclusion: Our study reports for the first time an association between rs9923231 and vascular dementia, but further research is warranted to explore potential mechanisms and specify the relationship between rs9923231 and features of vascular dementia.

Sign in / Sign up

Export Citation Format

Share Document