scholarly journals Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Abida Kalsoom Khan ◽  
Ain Us Saba ◽  
Shamyla Nawazish ◽  
Fahad Akhtar ◽  
Rehana Rashid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Short Review ◽  
Ferromagnetic Nanoparticles ◽  
The Past ◽  
Different Types

Over the past few years, considerable attention has been focused on carrageenan based bionanocomposites due to their multifaceted properties like biodegradability, biocompatibility, and nontoxicity. Moreover, these composites can be tailored according to the desired purpose by using different nanofillers. The role of ferromagnetic nanoparticles in drug delivery is also discussed here in detail. Moreover, this article also presents a short review of recent research on the different types of the carrageenan based bionanocomposites and applications.

scholarly journals The journey of Claire in the works of Gaito Gazdanov: the analysis of the female image of Claire in the novels “An Evening with Claire”, “Hannah”, and “The Fate of Salome”

Litera ◽  
2021 ◽  
pp. 162-170
Author(s):  
Ziwei Zhu
Keyword(s):  
Real World ◽  
The Novel ◽  
The Past ◽  
Character Type ◽  
Female Image ◽  
Different Types ◽  
Inner World ◽  
New Perspective ◽  
Gradual Transformation

  This article is dedicated to the analysis of the female image of Claire and its variant in the works of Gaito Gazdanov. This character type in the works of G. Gazdanov often resembles the past in the present, i.e. an important part of the “lost world” for the protagonist. However, deliberate examination allows following the gradual transformation of the authors attitude towards the character of Claire throughout his creative path. In the novel “Ab Evening with Clair”, the author adheres to priority of that past world over the present, while in the novel of his later period “The Fate of Salome”, the narrator tends to release from the shadow of the past. The underlying cause for such change lies in the transition of the writer from the romantic theurgical worldview towards phenomenal. In the later period, Gazdanov reconsidered the real world and justified the earthly existence due to the fact that submerging into the own inner world can entail loneliness and dissolution “Self” in one’s mind. The goal of this research consists in tracing the transformation of the role of Claire in the works of Gaito Gazdanov, as well as in description of different types of relations between the protatonist and the heroine in order to prove the evolution of the writer's reasoning on the problem of “two-worldness”. The relevance of this article consists in explication of the type of Claire in Gazdanov’s artistic system of “two-worldness” as a literary technique, as well as from the new perspective of studying the evolution the writer’s worldview.  

scholarly journals The Role of Public-Private Partnerships in Higher Education How Tertiary Institutions in emerging Economies benefit from Public-Private Partnerships

2017 ◽  
Vol 2 (1) ◽  
pp. 1-7
Author(s):  
Ronak Warasthe
Keyword(s):  
Higher Education ◽  
Emerging Economies ◽  
Tertiary Education ◽  
Added Value ◽  
Public Private Partnerships ◽  
Tertiary Institutions ◽  
The Past ◽  
Different Types ◽  
Insight Into

Abstract The number of Public-Private Partnerships in the education sector is growing in developing and emerging economies. Traditionally governments are the main financial contributor to education however, the involvement of the private sector is an increasing one. While more established in primary and secondary education, PPPs in tertiary education are a phenomenon rather slowly growing in the past decades (Patrinos, Barrera-Osorio, & Guaqueta, 2009). There are various concepts of PPPs in higher education each targeting different goals. In order to give an insight into different types of PPPs, the typology according to Mabizela has been briefly displayed and the case of a PPP in Namibia is given. The framework of the partnership was compiled to give an outlook on the practicability of partnerships. The paper exemplifies that both partners within a PPP can benefit from the added value they may generate for their target group. Thus, the benefit depends on quality, relevance and execution of the partnership.

scholarly journals The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 642 ◽  
Author(s):  
Donald A. Tomalia ◽  
Linda S. Nixon ◽  
David M. Hedstrand
Keyword(s):  
Drug Delivery ◽  
Metal Cluster ◽  
Design Parameters ◽  
Void Space ◽  
The Past ◽  
Cell Symmetry ◽  
Family Types ◽  
Approved Drugs

This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

Circulation, Conditions, Claims: Examining the Politics of Historical Memory in Eastern Europe

2021 ◽  
pp. 088832542096978
Author(s):  
Félix Krawatzek ◽  
George Soroka
Keyword(s):  
Eastern Europe ◽  
Special Section ◽  
Historical Memory ◽  
The Past ◽  
Different Types ◽  
Form Part ◽  
Regime Types ◽  
Individual Contributions ◽  
The Individual

Across Eastern Europe how the past is remembered has become a crucial factor for understanding present-day political developments within and between states. In this introduction, we first present the articles that form part of this special section through a discussion of the various methods used by the authors to demonstrate the potential ways into studying collective memory. We then define the regional characteristics of Eastern Europe’s mnemonic politics and the reasons for their oftentimes conflictual character. Thereafter we consider three thematic arenas that situate the individual contributions to this special section within the wider scholarly debate. First, we examine the institutional and structural conditions that shape the circulation of memory and lead to conflictive constellations of remembering; second, we discuss how different regime types and cultural rules influence the framing of historical episodes, paying attention to supranational integration and the role of technological change; third, we consider the different types of actors that shape the present recall of the past, including political elites, social movements, and society at large. We conclude by identifying several promising avenues for further research.

scholarly journals The Role of Visual Inspection in the 21st Century

2017 ◽  
Vol 61 (1) ◽  
pp. 262-266 ◽  
Author(s):  
Judi E. See ◽  
Colin G. Drury ◽  
Ann Speed ◽  
Allison Williams ◽  
Negar Khalandi
Keyword(s):  
21St Century ◽  
Visual Inspection ◽  
Past Research ◽  
Vital Role ◽  
Automated Detection ◽  
Lessons Learned ◽  
The Past ◽  
Different Types ◽  
Inspection Process

Visual inspection research has a long history spanning the 20th century and continuing to the present day. Current efforts in multiple venues demonstrate that visual inspection continues to have a vital role for many different types of tasks in the 21st century. The nature of this role spans the range from traditional human visual inspection to fully automated detection of defects. Consequently, today’s practitioners must not only successfully identify and apply lessons learned from the past, but also explore new areas of research in order to derive solutions for modern day issues such as those presented by introducing automation during inspection. A key lesson from past research indicates that the factors that can degrade performance will persist today, unless care is taken to design the inspection process appropriately.

scholarly journals Role of Multidisciplinary Care in the Management of Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Kia Byrd ◽  
Saleh Alqahtani ◽  
Adam C. Yopp ◽  
Amit G. Singal
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multidisciplinary Approach ◽  
Treatment Options ◽  
Multidisciplinary Care ◽  
Multimodal Approach ◽  
Poor Survival ◽  
The Past ◽  
Different Types ◽  
Potential Structure

AbstractDespite advances in treatment options for hepatocellular carcinoma (HCC), 5-year survival for HCC remains below 20%. This poor survival is multifactorial but is partly related to underuse of curative treatment in clinical practice. In light of growing treatment options, delivered by different types of providers, optimal management requires input from multiple specialties. A multidisciplinary approach has been evolving over the past couple of decades, bringing different specialists together to develop a therapeutic plan to treat and manage HCC, which significantly increases timely guideline-concordant treatment and improves overall survival. The present review attempts to highlight the need for such a multimodal approach by providing insights on its potential structure and impact on the various aspects of HCC management.

scholarly journals Semantic and Motivational Characteristics of Neolexemes of Enmity: Discursive Disclosure of Inner Form of the Word

2020 ◽  
Vol 1 (8) ◽  
pp. 141-155
Author(s):  
L. N. Rebrina
Keyword(s):  
Russian Language ◽  
Special Role ◽  
Internet Communication ◽  
Discursive Practices ◽  
The Past ◽  
Classification Feature ◽  
Different Types ◽  
Thinking Strategies

The article presents the results of a study of a number of Russian-language neolexemes functioning in Internet communication over the past two decades. The object of the analysis are subjects designations with the suffix –oid (Russian isteroid, oranzhoid, etc.). By their pragmatic components of meaning we consider these lexical units to be the vocabulary of enmity. They are united by the special role of the structural motivator in the formation of motivational meaning. Semantic and motivational characteristics of the nouns are described. Their partner tokens are found out. Conclusions are made about the influence of atypical combinatorics on the meaning of the word-forming component and on the transformed classification feature; about the blurring of boundaries between different language variants and styles. It is shown that in the immediate context, the properties attributed to the designated subjects are verbalized. The author analyzes the regularities of discursive disclosure of the inner form of the studied units by means of explication of motivational connections within different types of motivation. It is revealed that the most frequent way to actualize motivational models in the addressee’s speech-thinking strategies in Internet communication is the explication of lexical motivation and metatext motivation, while the explication of structural motivation and occasional author’s motivation are less frequent. It is shown that the specificity of discursive practices affects the reflecting consciousness of the addressee, and the patterns of representation of motivational models are refracted through the features of discourse.

scholarly journals Small RNAs, Big Diseases

2020 ◽  
Vol 21 (16) ◽  
pp. 5699 ◽  
Author(s):  
Iwona Rzeszutek ◽  
Aditi Singh
Keyword(s):  
Neurodegenerative Diseases ◽  
Small Rnas ◽  
Review Article ◽  
Human Diseases ◽  
Therapeutic Approaches ◽  
Related Research ◽  
The Past ◽  
Different Types

The past two decades have seen extensive research done to pinpoint the role of microRNAs (miRNAs) that have led to discovering thousands of miRNAs in humans. It is not, therefore, surprising to see many of them implicated in a number of common as well as rare human diseases. In this review article, we summarize the progress in our understanding of miRNA-related research in conjunction with different types of cancers and neurodegenerative diseases, as well as their potential in generating more reliable diagnostic and therapeutic approaches.

scholarly journals Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Liliana R. Balahura ◽  
Aida Selaru ◽  
Sorina Dinescu ◽  
Marieta Costache
Keyword(s):  
Proinflammatory Cytokines ◽  
Tumor Development ◽  
The Past ◽  
Persistent Inflammation ◽  
Gene And Protein Expression ◽  
Different Types ◽  
Pros And Cons ◽  
Promote Cell Death ◽  
Made In

Over the past decade, it has been well established that tumorigenesis is affected by chronic inflammation. During this event, proinflammatory cytokines are produced by numerous types of cells, such as fibroblasts, endothelial cells, macrophages, and tumor cells, and are able to promote the initiation, progression, and metastasis of different types of cancer. When persistent inflammation occurs, activation of inflammasome complexes is initiated, leading to its assembly and further activation of caspase, production of proinflammatory cytokines, and pyroptosis induction. The function of this multiprotein complex is not only to reassure inflammation and to promote cell death, through caspase activity, but also has been identified to have significant contributions during tumorigenesis and cancer development. So far, many efforts have been made in order to extend the knowledge of inflammasome implications and how its components could be targeted as therapeutic agents. Additionally, microRNAs (miRNAs), evolutionary conserved noncoding molecules, have emerged as pivotal players during numerous biological events by regulating gene and protein expression. Therefore, dysregulations of miRNA expressions have been correlated with inflammation during tumor development. In this review, we aim to highlight the dual role of inflammasomes and proinflammatory cytokines during carcinogenesis paired with the distinguished effects of miRNAs upon inflammation cascades during tumor growth and progression.

Nostalgic neighborhood belongings: Theorizing the interrelationship among nostalgias, belongings and neighborhood changes

2021 ◽  
pp. 003802612110294
Author(s):  
Clément Colin
Keyword(s):  
Empirical Research ◽  
The Other ◽  
The Past ◽  
Physical Environments ◽  
The Social ◽  
Different Types ◽  
The One ◽  
Depth Interviews

Depending on one’s socio-territorial contexts, age, and time spent residing in the same place, the spatial-temporal experience of belonging is lived differently. Within this framework, this article looks at perspectives of neighborhood belonging in long-term residents aged 65 years and older. Based on the narratives of 51 people from three neighborhoods of Valparaíso, Chile, who participated in the 2019 workshops and/or in-depth interviews, I identify different types of nostalgic senses of belonging; and examine the social and spatial conditions that influence their formation. From this empirical research, I argue that these belongings are based on daily practices that refer to the past neighborhood and that, at the same time, are embodied in their current materialities. The results show, on the one hand, the role of nostalgia in the formation of a belonging, from the past to the present; and, on the other, the influence of place in these experiences. From the above, this article contributes to the conceptualization of the material dimension of nostalgic belongings and their interrelationships among nostalgias, belongings, and changes in social and physical environments.

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