scholarly journals Accurate Measurement of Mitochondrial DNA Deletion Level and Copy Number Differences in Human Skeletal Muscle

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114462 ◽  
Author(s):  
John P. Grady ◽  
Julie L. Murphy ◽  
Emma L. Blakely ◽  
Ronald G. Haller ◽  
Robert W. Taylor ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Human Skeletal Muscle ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion

scholarly journals Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

2006 ◽  
Vol 79 (3) ◽  
pp. 469-480 ◽  
Author(s):  
Entela Bua ◽  
Jody Johnson ◽  
Allen Herbst ◽  
Bridget Delong ◽  
Debbie McKenzie ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Human Skeletal Muscle ◽  
Muscle Fibers ◽  
Mitochondrial Dna Deletion ◽  
Deletion Mutations ◽  
Dna Deletion ◽  
Skeletal Muscle Fibers

Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle

2020 ◽  
Author(s):  
Allen Herbst ◽  
Cathy C. Lee ◽  
Amy R. Vandiver ◽  
Judd M. Aiken ◽  
Debbie McKenzie ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Human Skeletal Muscle ◽  
Mitochondrial Dna Deletion ◽  
Deletion Mutations ◽  
Dna Deletion

scholarly journals Hypokinesia Causes Oxidative Damage and Mitochondrial DNA Deletion in Rat Skeletal Muscle.

1997 ◽  
Vol 9 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Yasutomo Sakai ◽  
Yukio Iwamura ◽  
Hiroshi Nagata ◽  
Nao Yamamoto ◽  
Norio Ohkoshi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Rat Skeletal Muscle ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion

Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle

1999 ◽  
Vol 22 (2) ◽  
pp. 258-261 ◽  
Author(s):  
Yasutomo Sakai ◽  
Yukio Iwamura ◽  
Jun-Ichi Hayashi ◽  
Nao Yamamoto ◽  
Norio Ohkoshi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Acute Exercise ◽  
Rat Skeletal Muscle ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

1992 ◽  
Vol 275 (3-6) ◽  
pp. 181-193 ◽  
Author(s):  
M.N. Gadaleta ◽  
G. Rainaldi ◽  
A.M.S. Lezza ◽  
F. Milella ◽  
F. Fracasso ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Mitochondrial Dna Copy Number

Stable heteroplasmy but differential inheritance of a large mitochondrial DNA deletion in nematodes

2002 ◽  
Vol 80 (5) ◽  
pp. 645-654 ◽  
Author(s):  
William Y Tsang ◽  
Bernard D Lemire
Keyword(s):  
Mitochondrial Dna ◽  
Caenorhabditis Elegans ◽  
Copy Number ◽  
Mitochondrial Diseases ◽  
Wild Type ◽  
Mtdna Copy Number ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Average Proportion ◽  
Mtdna Deletion

Many human mitochondrial diseases are associated with defects in the mitochondrial DNA (mtDNA). Mutated and wild-type forms of mtDNA often coexist in the same cell in a state called heteroplasmy. Here, we report the isolation of a Caenorhabditis elegans strain bearing the 3.1-kb uaDf5 deletion that removes 11 genes from the mtDNA. The uaDf5 deletion is maternally transmitted and has been maintained for at least 100 generations in a stable heteroplasmic state in which it accounts for ~60% of the mtDNA content of each developmental stage. Heteroplasmy levels vary between individual animals (from ~20 to 80%), but no observable phenotype is detected. The total mtDNA copy number in the uaDf5 mutant is approximately twice that of the wild type. The maternal transmission of the uaDf5 mtDNA is controlled by at least two competing processes: one process promotes the increase in the average proportion of uaDf5 mtDNA in the offspring, while the second promotes a decrease. These two forces prevent the segregation of the mtDNAs to homoplasmy.Key words: mtDNA deletion, Caenorhabditis elegans, heteroplasmy, inheritance, mtDNA copy number.

Sign in / Sign up

Export Citation Format

Share Document