Guided wave (GW) testing is regularly used for finding defect locations through long-range screening using low-frequency waves (from 5 to 250 kHz). By using magnetostrictive sensors, some issues, which usually limit the application to nuclear power plants (NPPs), can be fixed. The authors have already shown the basic theoretical background and simulation results concerning a real steel pipe, used for steam discharge, with a complex structure. On the basis of such theoretical framework, a new campaign has been designed and developed on the same pipe, and the obtained experimental results are now here presented as a useful benchmark for the application of GWs as nondestructive techniques. Experimental measures using a symmetrical probe and a local probe in different configurations (pulse-echo and pitch-catch) indicate that GW testing with magnetostrictive sensors can be reliably applied to long-term monitoring of NPPs components.