scholarly journals 28. The Potential of Red Watermelon Extract (Citrullus vulgaris) to Decrease Blood Glucose Levels in Mice (Mus musculus) Were Exposed with Cigarette Smoke

2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Irfani Rahmi ◽  
Roslizawaty Roslizawaty ◽  
Azhar Azhar ◽  
Razali Daud ◽  
Syafruddin Syafruddin ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cigarette Smoke ◽  
Mus Musculus ◽  
Citrullus Vulgaris ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Decrease Blood Glucose

scholarly journals KADAR GLUKOSA DARAH MENCIT (MUS MUSCULUS) DIABETES MELLITUS PASKA PEMBERIAN MODEL LATIHAN ISOMETRIK

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Sonia Hardiyanti ◽  
Harmayetty Harmayetty ◽  
Ika Yuni Widyawati
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Isometric Exercise ◽  
Exercise Group ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels ◽  
Decrease Blood Glucose ◽  
Kolmogorov Smirnov

Introduction: Based on the latest research, exercise had significant effect to decrease blood glucose. The aimed of this study was to investigate the effect of isometric exercise model on blood glucose in Diabetic Mice (Mus musculus).Methodes: This research was used a true experimental study with randomize post-test only control group design. The sample was male mice (Mus musculus) in 20-27 grams weight. 27 male mice were divided into three groups; the first group was normal group (control) that injected by NaCl as placebo, the second group was diabetic mice and the third group was diabetic mice with exercise. Both second group and third group were injected by streptozotocin (STZ) to induce Diabetes Mellitus. After 2x24 hours injected, all groups were given oral glucose (Dextrose-40% or D40). One hour after they given by D40, the third group was treated by isometric exercise used treadmill for 23.31 minutes with 21 cm/second speed and 0° elevation angle. Then the blood samples of all groups were taken to measure the blood glucose level. Data were analyzed by One Kolmogorov-Smirnov test, ANOVA test, and Least Significance Difference (LSD) with significance level of α<0.05.Result: The result of One Kolmogorov-Smirnov test showed that there was p=0.94 in normal group, p=0.50 in diabetic group, and p=0.19 in diabetic with exercise group. The result of ANOVA test was p=0.08. The result of LSD for blood glucose revealed was p=0.23 for diabetic group and diabetic with exercise group. The researcher had an assumption that probably it happened because of in second group there were two mice that had normal blood glucose levels and in the third group the initial blood glucose levels were unknown, hence they probably could had normal blood glucose levels too. Discussion: It can be concluded that there is no effect of isometric exercise to decrease blood glucose. Further research should investigate more about the frequency and intensity of isometric exercise that could has effect to decrease blood glucose.

scholarly journals Efek Hipoglikemik Kecambah Beras Merah pada Tikus yang Diinduksi STZ-NA dengan Parameter Kadar Insulin, Indeks HOMA-IR dan HOMA β (Hypoglycemic Effect of Red Rice Germ on Insulin Levels, HOMA-IR, and HOMA β Index of STZ-NA Induced Rats)

2017 ◽  
Vol 36 (4) ◽  
pp. 433
Author(s):  
Nurhidajah Nurhidajah ◽  
Nurrahman Nurrahman
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Insulin Level ◽  
Control Group ◽  
Standard Diet ◽  
Red Rice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Decrease Blood Glucose

The process of germination of grains such as rice, could increase some nutritional values of  amino acids and dietary fiber. Red rice and its sprouts are believed to be able to decrease blood glucose in patients with diabetes mellitus (DM). The aim of this study was to evaluate the hypoglycemic effect of red rice sprouts in STZ-NA induced diabetic rats on blood glucose level, insulin level, and HOMA-IR and HOMA-β index. This experimental study was conducted based on randomized post test only control group design using 24 male Wistar rats aged 2.5 months. Rats were divided into 4 groups, one group without induction of STZ-NA fed with a standard diet (control) and three groups of STZ- NA induced with a standard diet, red rice and red rice germ. Experiments were conducted for 6 weeks. The results showed that sprouted red rice lowered blood glucose levels by 61.88 % and the value of HOMA-IR (insulin resistance parameters) by 56.82%. Insulin level increased by 16.35 % and HOMA-β by 763.6 %. This study showed that red rice germ was able to decrease blood glucose levels and increase insulin resistance of DM rats and the strength of the pancreatic beta cells. ABSTRAKProses perkecambahan biji-bijian seperti beras, dapat meningkatkan beberapa nilai gizi seperti asam amino dan serat pangan. Beras merah dan kecambahnya diyakini mampu menurunkan glukosa darah pada penderita diabetes melitus (DM). Tujuan penelitian ini adalah mengevaluasi efek hipoglikemik kecambah beras merah pada tikus diabetes yang diinduksi STZ-NA terhadap kadar glukosa darah, insulin, serta indeks HOMA-IR dan HOMA β. Penelitian ini bersifat eksperimental in vivo pada hewan coba tikus Wistar jantan usia 2,5 bulan sebanyak 24 ekor dengan desain penelitian randomized post test only control group. Tikus dibagi menjadi 4 kelompok, masing-masing 1 kelompok tanpa induksi STZ-NA dengan diet standar dan 3 kelompok diinduksi STZ-NA dengan diet standar, beras merah dan kecambah beras merah. Percobaan dilakukan selama 6 minggu. Hasil penelitian menunjukkan kecambah beras merah mampu menurunkan kadar glukosa darah sebesar 61,88 % dan nilai HOMA-IR (parameter resistensi insulin) 56,82 %. Kadar insulin meningkat 16,35 % dan HOMA β 763,6 %. Disimpulkan, kecambah beras merah mampu menurunkan kadar glukosa darah dan memperbaiki kondisi resistensi insulin tikus DM, dan kekuatan sel beta pankreas.

scholarly journals Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice ( Mus musculus )

2016 ◽  
Vol 6 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Faizal Rajeeb Mangudadatu Hussin ◽  
Rodel Jonathan Santos Vitor ◽  
Julie Ann Oraa Joaquin ◽  
Melody Mendoza Clerigo ◽  
Anamy Ma. Caterial Paano
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
The Philippines ◽  
Glucose Levels ◽  
Icr Mice ◽  
Blood Glucose Levels ◽  
Lenzites Betulina

scholarly journals PEMANFAATAN INFUSA DAUN SIRIH MERAH (Piper crocatum) SEBAGAI ANTI-OBESITAS PADA MENCIT (Mus musculus)

2020 ◽  
Vol 10 ◽  
pp. 50-57
Author(s):  
Desty Apritya ◽  
Miarsono Sigit ◽  
Retina Yunani ◽  
Fuji Lestari
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Experimental Animals ◽  
Betel Leaf ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Randomized Design ◽  
Obesity In Mice ◽  
Sugar Levels ◽  
The Relationship

The purpose of this research is to know the effectiveness of red betel leaf infusion (Piper crocatum) as anti-obesity in mice (Mus musculus). Other parameters of this study to know the relationship between changes in blood glucose levels to obesity in experimental animals. Experimental animals used were 24 male mice. The design of this research is completely randomized design (CRD) with 4 treatments 6 repetitions. There are four treatmens P0 (Control), P1 (6 mice by giving a betel leaf infusion with a concentration of 5%), P2 (6 mice by giving a betel leaf infusion with a concentration of 10%), and P3 (6 mice by giving a betel leaf infusion with a concentration of red 15%). The treatment is carried out once every day for 21 days. Before treatment, initial weight was weighed and blood glucose level examination continued on the 7th day, on the 14th day, and on the 21st day. Data obtained from the results of weighing and checking blood sugar levels were further analyzed using the ANOVA test which statistically showed no significant changes (P> 0.05) of body weight and blood glucose levels in mice (Mus musculus) given infusion red betel leaf (Piper crocatum).

scholarly journals Antihyperglycemic Activity of Aqueous Extract of Insulin Leaves (Tithonia diversifolia) on Hyperglycemic Rats (Rattus norvegicus)

2018 ◽  
Vol 10 (3) ◽  
pp. 636-641
Author(s):  
Anisa Rachma Sari ◽  
Tyas Rini Saraswati ◽  
Enny Yusuf Wachidah Yuniwarti
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Rattus Norvegicus ◽  
Tithonia Diversifolia ◽  
Antihyperglycemic Activity ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Decrease Blood Glucose

Insulin leave (Tithonia diversifolia (Hemsl.) A. Gray) empirically used by people as antihyperglycemic drugs. The study was aimed to evaluate antihyperglycemic activity as well as to determine the most optimum dose of T. diversifolia to reduce blood glucose levels. Hyperglycemic condition was induced to male Rattus norvegicus rats by intraperitoneal injection of alloxan at a dose of 150 mg/kg bw (body weight). In this study, completely randomized design was performed with three treatment groups and five times repetition. Group P1 received glibenclamide 10 mg/kg bw, P2 received aqueous extract of T. diversifolia at a dose of 150 mg/kg bw, P3 received aqueous extract of T. diversifolia at a dose of 300 mg/kg bw. Administration of both glibenclamide and aqueous extract of T. diversifolia was conducted orally for 28 days. Data were analyzed using Anova and Duncan’s test with 95% confidence level (α = 0.05). The results showed that the mean percentage of decrease in blood glucose levels, drink intake and body weight of all treatment groups were not significantly different (p>0.05). Data of feed intake showed that P1 was significantly different from P2 (p<0.05), but P2 was not significantly different from P3 (p>0.05). Based on the result of this research, it was found that the low doses of aqueous extract of T. diversifolia has the same ability to decrease blood glucose level compared to glibenclamide. Futhermore, this study provide some information that can be used as preclinical analysis to determine effective doses of aqueous extract of T. diversifolia to decrease blood glucose levels.  

scholarly journals PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Pipit Festi W
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Mus Musculus ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

scholarly journals BLOOD GLUCOSE LEVEL AND PANCREAS HISTOLOGICAL SECTION OF MICE ( Mus musculus L.) INDUCED BY ALLOXAN AFTER TREATMENT OF Curcuma mangga Val. RHIZOME EXTRACT

2016 ◽  
Vol 20 (2) ◽  
pp. 64 ◽  
Author(s):  
Madihah Madihah ◽  
Fitriani Alfina ◽  
Yetti Yusri Gani
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Fasting Blood Glucose ◽  
Histological Section ◽  
Tolerance Test ◽  
Endocrine Gland ◽  
Synthetic Drugs ◽  
Glucose Levels ◽  
Blood Glucose Levels

Herbal-based drug development for diabetes mellitus continues to grow in order to find alternatives of theuse of synthetic drugs which is relatively expensive. The present study examined the potency of temu mangga(Curcuma mangga Val.) rhizome extract in decreasing blood glucose levels and repairing histological damage ofpancreas endocrine gland in male mice (Mus musculus L.) Swiss-Webster that has been induced by alloxan. Theexperimental method with 5 treatments and 5 replications were used. The dose of alloxan was 200 mg/kg bw,while the dose of temu mangga extract were 100, 200, 400 and 800 mg/kg bw. The measured parameters werethe body weight, fasting blood glucose levels by using blood glucose tolerance test, and the percentage of pancreatic? cells that undergo necrosis. Data were analyzed by ANOVA with 95% confidence level and continued withDuncan’s multiple range tests. The results showed no difference on body weight of test animals in all treatments.The reduction percentage of fasting blood glucose levels from temu mangga rhizome extract by dosage of 400mg/kg bw (48.712%) was significantly different from the treatment of alloxan (0.588%) (p<0.05). The percentageof ? cells that undergo necrosis from temu mangga rhizome by dosages of 200, 400, and 800 mg/kg bw weresignificantly different with alloxan (22.75±3.68 %) (p<0.05). In conclusion, temu mangga rhizome extract bydosage of 400 mg/kg was optimum to decrease blood glucose levels and repair the pancreas histological damagein mice that were induced by alloxan.

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