scholarly journals The history of melanoma diagnostics

2021 ◽  
Vol 9 (3) ◽  
pp. 132-137
Author(s):  
Paula Kamińska ◽  
Karolina Buszka ◽  
Michał Nowicki ◽  
Joanna Budna-Tukan
Keyword(s):  
Current Knowledge ◽  
Diagnostic Methods ◽  
Therapeutic Management ◽  
Historical Overview ◽  
Circulating Tumour Cells ◽  
Laboratory Methods ◽  
Treatment Methods ◽  
Historical Outline ◽  
History Of

Abstract This article provides a historical overview of melanoma, involving the knowledge of this neoplasm from antiquity to the present. Selected people who made key descriptions of the disease, its symptoms, and treatment methods were listed. The classification of melanoma, which is used in therapeutic management nowadays, is briefly discussed. Additionally, we describe circulating tumour cells and the selected diagnostic methods associated with their detection and characteristics. The aim of this article is to present a historical outline of melanoma, as well as its classification and the development of laboratory methods of its diagnosis. In addition, we have also provided a comparison of historical and current knowledge of this malignancy.

Adenomyosis – its possible effect on endometrial function and receptivity

2021 ◽  
Vol 86 (3) ◽  
pp. 205-209
Author(s):  
Karel Crha ◽  
◽  
Michal Ješeta ◽  
Radovan Pilka ◽  
Pavel Ventruba ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Current Knowledge ◽  
Histopathological Examination ◽  
Transvaginal Ultrasound ◽  
Embryo Implantation ◽  
Diagnostic Methods ◽  
Mesenchymal Transition ◽  
New Information

Summary Objective: There have been many studies on adenomyosis, which can impair the quality of life of a woman. There are various kinds of opinions on the pathogenesis, diagnostics and treatment of adenomyosis. The goal of this article is to present the current knowledge of adenomyosis and its impact on the endometrial function and receptivity. Methods: PubMed/Medline, Web of Sciences and Scopus were searched for the articles in English indexed until February 2021 with terms of: adenomyosis, endometrial receptivity, and infertility. Results: Recent studies on angiogenesis and epithelial-mesenchymal transition in the endometrium bring new information on the ethiology and pathogenesis of adenomyosis. In clinical practice, the main diagnostic methods of adenomyosis include transvaginal ultrasound, magnetic resonance imaging or hysteroscopy, although the definitive confirmation is set by histopathological examination. The rules of #Enzian classification of endometriosis should be applied for the classification of adenomyosis. The treatment of adenomyosis should consider individual clinical presentation and reproductive plans of a patient and should be performed in centers for the treatment of endometriosis. Conclusion: Adenomyosis affects endometrial vascularisation and epithelial-mesenchymal transition/mesenchymal-epithelial transition; thus, it can be the cause of irregular uterine bleeding or embryo implantation failure. The research and analysis of endometrial proteome could lead to the new ways of adenomyosis treatment.

scholarly journals Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease

2013 ◽  
Vol 39 (6) ◽  
pp. 728-741 ◽  
Author(s):  
Daniel Antunes Silva Pereira ◽  
Alexandre de Melo Kawassaki ◽  
Bruno Guedes Baldi
Keyword(s):  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Connective Tissue Disease ◽  
Current Knowledge ◽  
Pulmonary Involvement ◽  
Pathophysiological Role ◽  
History Of

The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest the presence of a rheumatic disease, are routinely performed at various referral centers. When interstitial lung involvement is the condition that allows the definitive diagnosis of connective tissue disease and the classical criteria are met, there is little debate. However, there is still debate regarding the significance, relevance, specificity, and pathophysiological role of autoimmunity in patients with predominant pulmonary involvement and only mild symptoms or formes frustes of connective tissue disease. The purpose of this article was to review the current knowledge of autoantibody positivity and to discuss its possible interpretations in patients with ILD and without clear etiologic associations, as well as to enhance the understanding of the natural history of an allegedly new disease and to describe the possible prognostic implications. We also discuss the proposition of a new term to be used in the classification of ILDs: lung-dominant connective tissue disease.

Intramuscular Haemangioma of the Extensor Pollicis Brevis Muscle with Periosteal Reaction of the Radius: A Case Report and Review of the Literature

2007 ◽  
Vol 35 (5) ◽  
pp. 724-730 ◽  
Author(s):  
EH Kayias ◽  
GI Drosos ◽  
KI Kazakos ◽  
C Iatrou ◽  
KS Blatsoukas ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Periosteal Reaction ◽  
Review Of The Literature ◽  
Tissue Mass ◽  
Bone Changes ◽  
History Of ◽  
Intramuscular Haemangioma ◽  
History Of Pain ◽  
The Right

We report the rare case of a histologically proven mixed-type intramuscular haemangioma, adjacent to the periosteum of the radius, that caused a periosteal reaction. We also carried out a review of the literature relevant to this case. A 28-year-old male professional drummer presented with an 8-month history of pain and swelling of the dorsal aspect of the right radius. Diagnosis was established on the basis of plain radiographs and magnetic resonance imaging, and was confirmed by histology. The lesion was treated solely by resection of the soft-tissue mass. The patient remained asymptomatic 4 years post-operatively, with no radiographic signs of recurrence. From a review of the literature, it is evident that the terminology for haemangiomas causing regional bone changes is unclear. A new classification of the intramuscular haemangiomas is proposed in order to distinguish between lesions that, according to current knowledge, exhibit radiological and clinical areas of overlap.

scholarly journals The history of research of the ophthalmic aspects of hypertension

2021 ◽  
Vol 9 (1) ◽  
pp. 14-18
Author(s):  
Aleksandra Krasińska ◽  
Agata Brązert ◽  
Jarosław Kocięcki
Keyword(s):  
Diagnostic Methods ◽  
Hypertensive Retinopathy ◽  
Cotton Wool Spots ◽  
Microvascular Changes ◽  
History Of Research ◽  
Organ Systems ◽  
History Of ◽  
Funduscopic Examination ◽  
Retinal Exudates

Abstract The awareness of the widespread influence of hypertension on various organ systems is ever increasing. Changes associated with this disease can be observed in the heart, brain, kidneys, but also the organ of vision. These usual microvascular changes are defined as hypertensive retinopathy. During a funduscopic examination, abnormalities such as narrowing of arterioles, symptoms of arteriole and vein intersection, cotton wool spots, intra-retinal exudates, retinal haemorrhages, and in severe cases even swelling of the optic disc and macula. This review presents an overview of the changes at the fundus of the eye that may occur in patients with hypertension, as well as problems with the classification of hypertensive retinopathy over the years, and the development of diagnostic methods in ophthalmology and fundoscopic imaging. Running title: The history of hypertensive retinopathy research

Pathology of the urachus. History of the issue and current state of the problem

2021 ◽  
Vol 11 (2) ◽  
pp. 141-152
Author(s):  
Dmitriy N. Shchedrov ◽  
Igor S. Shormanov ◽  
Sergey V. Kotov ◽  
Eugene V. Morozov
Keyword(s):  
Laparoscopic Approach ◽  
Comparative Assessment ◽  
Diagnostic Methods ◽  
Malignant Neoplasms ◽  
Current State ◽  
Modern Classification ◽  
History Of ◽  
Adults And Children ◽  
Gender Aspect

Based on the analysis of literature sources, modern data are presented on the nosological structure of urachus diseases in adults and children, diagnostic methods, as well as treatment tactics for various anatomical variants of anomalies in the development of the urinary duct. A modern classification of urachal malformations caused by disorders of its obliteration is presented. Various modifications of the laparoscopic approach are considered for the most common types of this pathology. The reasons for the development of malignant neoplasms from the urachus tissue, including in the gender aspect, are described, and a comparative assessment of the methods of surgical treatment of urachus tumors is given.

scholarly journals Reverse “Y” Shape Fistula - a Paricularity in the Evolution of Postanal Space Abscesses

2020 ◽  
Vol 70 (12) ◽  
pp. 4504-4506
Keyword(s):  
Advancement Flap ◽  
Diagnostic Methods ◽  
Perineal Fistula ◽  
Anatomical Features ◽  
Lesion Type ◽  
Horseshoe Fistula ◽  
History Of ◽  
Postanal Space

Horseshoe fistula, with an incidence of less than 3% of the total perianal fistulas, is an atypical lesion not included in the classification of Parks. Its specificity is given by the anatomical features of the postanal space, respectively the presence of the anococcygeal ligament. This type of perineal fistula has a particular tract in shape of a reverse „Y”. We present the cases of 12 patient diagnosed with posterior horseshoe fistula with deep postanal space abscess surgically treated during 2013-2017. The study is retrospective and observative and it includes the history of the disease, the diagnostic methods, the surgical procedures performed and the postoperative evolution. As far as we are concerned, we based our approach on the advancement flap literature data, as well as on the role of the anococcygeal ligament in the pathology of this lesion type. After optimal control of the purulent collection from the postanal space and after the remission of local inflammatory phenomena, a correct advancement flap technique succeeds most often to resolve the septic area of the crypt of origin. We believe that current standards on the functional outcomes of these types of lesions require techniques that avoid the slow elastic cutting of the sphincter, minimizing the risk of incontinence. Keywords: postanal space abscess; anococcygeal ligament; horseshoe fistula; advancement flap

scholarly journals Evolutionary history and classification of Micropia retroelements in Drosophilidae species

2019 ◽  
Author(s):  
Juliana Cordeiro ◽  
Tuane L. Carvalho ◽  
Vera L. da S. Valente ◽  
Lizandra J. Robe
Keyword(s):  
Regulatory Networks ◽  
Evolutionary History ◽  
Current Knowledge ◽  
Natural Populations ◽  
Model Organism ◽  
Genomic Databases ◽  
New Genes ◽  
Gypsy Group ◽  
History Of

AbstractCurrent knowledge indicates TEs have been shaping the evolution of genomes and host species, contributing to the creation of new genes and promoting rearrangements frequently associated with new regulatory networks. Support for these hypothesis frequently result from studies with model species, and Drosophila detaches as a great model organism to the study of TEs. Micropia belongs to the Ty3/Gypsy group of LTR retroelements, and comprises one of the least studied Drosophila transposable elements. In this study, we assessed the evolutionary history of Micropia within Drosophilidae, while trying to assist in the classification of this TE. At first, we analyzed its presence in the genome of several species from natural populations and then, based on searches within genomic databases, we retrieved Micropia-like sequences from distinct Drosophilidae species genomes. We expanded the knowledge of Micropia distribution within Drosophila, and detected an array of divergent sequences, which allowed subdividing this retroelement in 20 subfamilies. Even so, a patchy distribution of Micropia sequences within the Drosophilidae phylogeny could be identified combined with incongruences of the species and the Micropia phylogenies. Comparing dS values between Micropia and host nuclear sequences, we found several cases of unexpected high levels of similarity between Micropia sequences found in divergent species. All these findings propose a hypothesis to the evolution of Micropia within Drosophilidae, including several VTTs and HTTs events, associated to ancestral polymorphisms and recurrent Micropia sequences diversification.

Karl Marx’s Legacy: The Historical Overview

2007 ◽  
pp. 87-103
Author(s):  
R. Nureev
Keyword(s):  
Marxist Theory ◽  
Neoclassical Economic ◽  
Historical Overview ◽  
Economic Theories ◽  
The Future ◽  
History Of ◽  
Western Marxism

The article is devoted to the history of reception and interpretation of the ideas of Marx and Engels. The author considers the reasons for divergence between Marxist and neoclassical economic theories. He also analyzes the ways of vulgarization of Marx’s theory and the making of Marxist voluntarism. It is shown that the works of Marx and Engels had a certain potential for their over-simplified interpretations. The article also considers academic ("Western") Marxism and evaluates the prospects of Marxist theory in the future.

To Understand the Informal (on the Book BY V. L. Tambovtsev “Economics of Informal Institutions”)

2015 ◽  
pp. 151-158
Author(s):  
A. Zaostrovtsev
Keyword(s):  
Social Psychology ◽  
Detailed Analysis ◽  
Human Behavior ◽  
Interdisciplinary Approach ◽  
Informal Institutions ◽  
Economic Thought ◽  
History Of ◽  
Original Classification

The review considers the first attempt in the history of Russian economic thought to give a detailed analysis of informal institutions (IF). It recognizes that in general it was successful: the reader gets acquainted with the original classification of institutions (including informal ones) and their genesis. According to the reviewer the best achievement of the author is his interdisciplinary approach to the study of problems and, moreover, his bias on the achievements of social psychology because the model of human behavior in the economic mainstream is rather primitive. The book makes evident that namely this model limits the ability of economists to analyze IF. The reviewer also shares the author’s position that in the analysis of the IF genesis the economists should highlight the uncertainty and reject economic determinism. Further discussion of IF is hardly possible without referring to this book.

The Accuracy of ACR TI-RADS Classification of Neck Ultrasound as a First-Line Diagnostic Approach for Thyroid Neoplasms in Pediatric Patients: A Retrospective Study

2018 ◽  
Vol 5 (1) ◽  
pp. 13-23
Author(s):  
Nikolai S. Grachev ◽  
Elena V. Feoktistova ◽  
Igor N. Vorozhtsov ◽  
Natalia V. Babaskina ◽  
Ekaterina Yu. Iaremenko ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Predictive Value ◽  
Thyroid Nodules ◽  
Pediatric Patients ◽  
Thyroid Neoplasms ◽  
Diagnostic Methods ◽  
Diagnostic Approach ◽  
First Line ◽  
Neck Ultrasound

Background.Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is the gold standard in diagnosing the pathological nature of undetermined thyroid nodules. However, in some instances limitations and shortcomings arise, making it insufficient for determining a specific diagnosis.Objective.Our aim was to evaluate the effectiveness of ACR TI-RADS classification of neck ultrasound as a first-line diagnostic approach for thyroid neoplasms in pediatric patients.Methods.A retrospective analysis was made of FNA and US protocols in 70 patients who underwent the examination and treatment at Dmitry Rogachev National Research Center between January 2012 and August 2017. In the retrospective series 70% (49/70) of patients undergone FNA and 43% (30/70) of them undergone repeated FNA. All US protocols were interpreted according to ACR TI-RADS system by the two independent experts. The clinical judgment was assessed using the concordance test and the reliability of preoperative diagnostic methods was analized.Results.According to histologic examination protocols, benign nodules reported greater multimorbidity 29% (20/70), compared with thyroid cancer 17% (12/70), complicating FNA procedure. A statistically significant predictor of thyroid cancer with a tumor size ACR TI-RADS showed a significant advantage of ACR TI-RADS due to higher sensitivity (97.6 vs 60%), specificity (78.6 vs 53.8%), positive predictive value (87.2 vs 71.4%), and negative predictive value (95.7 vs 41.2%). Concordance on the interpreted US protocols according to ACR TI-RADS classification between two experts was high, excluding accidental coincidence.Conclusion.The data support the feasibility of US corresponding to the ACR TI-RADS classification as a first-line diagnostic approach for thyroid neoplasm reducing the number of unnecessary biopsies for thyroid nodules.

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