scholarly journals Experimental infection with Baylisascaris potosis in chickens

2020 ◽  
Vol 57 (4) ◽  
pp. 384-387
Author(s):  
K. Taira ◽  
M. Ueda ◽  
H. K. Ooi
Keyword(s):  
Public Health ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Paratenic Host ◽  
Larva Migrans ◽  
Post Inoculation ◽  
Foodborne Disease ◽  
Public Health Importance ◽  
The Mean ◽  
The Brain

SummaryThe larvae of the genus Baylisascaris can cause larva migrans in mammals and birds. This study investigated the larval migration of Baylisascaris potosis, the roundworm of kinkajou (Potos flavus), in chickens and the associated clinical manifestations of the host. Thirty-six 3-week-old chickens divided into 6 groups were orally inoculated with 3,000 B. potosis eggs/chick. Each group of chicken was necropsied at days 1, 2, 3, 7, 30 and 90 PI (post inoculation), and the number of larvae in various organs were counted until day 90 PI. No clinical signs were observed in chickens during the study. Larvae were detected from the liver, lungs or breast-muscles of 13/36 (36.1%) chickens. The mean total number of larvae in the liver, lungs and breast-muscles at days 1, 2, 3, 7, 30 and 90 PI were 0.34, 0.17, 1.66, 1.01, 0.17 and 0, respectively. No larvae were found in the brain, eyes, hid-limb muscles, heart, kidneys and spleen. Although infectivity of larvae in egg-inoculated chickens was low, the present study demonstrated that B. potosis larvae can migrate in chickens tissues up to day 30 PI. The result suggests that chickens can serve as a paratenic host for B. potosis and may underline a public health importance of B. potosis infection as a potential foodborne disease in humans.

Clinico-Haematological Alterations in Goats Affected with Ruminal Acidosis

2017 ◽  
Vol 13 (02) ◽  
Author(s):  
P. R. Chavelikar ◽  
G. C. Mandali ◽  
D. M. Patel
Keyword(s):  
Clinical Signs ◽  
Clinical Manifestations ◽  
Nasal Discharge ◽  
Mean Values ◽  
Ruminal Acidosis ◽  
Reduced Body ◽  
Muscle Twitching ◽  
Haematological Profile ◽  
The Mean ◽  
Severity Of The Disease

Ruminal acidosis is one of the most important clinical emergencies in sheep and goats resulting into high mortality rate. In the present study, eight healthy farm goats and 24 goats presented to the TVCC of the college with clinical signs of ruminal acidosis like anorexia, tympany, increased pulse and respiratory rate, reduced body temperature, doughy rumen, enteritis, oliguria, grinding of teeth, purulent nasal discharge, muscle twitching, arched back, dehydration and recumbency with rumen liquor pH below 6 were examined for haematological alterations using autohaematoanalyzer. Among various haematological parameters evaluated from acidotic goats, the mean values of Hb (12.21±0.17 vs. 10.86±0.15 g/dl), TEC (14.28±0.16 vs. 12.04±0.36 ×106/ μl), TLC (13.43±0.11 vs. 11.11±0.27 ×103/μl), PCV (36.91±0.53 vs. 29.88±0.55%), neutrophils (64.54±0.93 vs. 28.13±0.92%), MCV (23.38±0.37 vs. 19.38±1.34 fl) and MCH (7.03±0.08 vs. 6.31±0.25 pg) were found significantly increased, while the mean values of lymphocytes (28.00±0.82 vs. 65.38±0.80%) and MCHC (24.55 ±0.26 vs. 34.88±0.97 g/dl) were decreased significantly from the base values of healthy goats. It was concluded that ruminal acidosis induced due to accidental heavy ingestion of readily fermentable carbohydrate rich grains and food waste significantly altered the haematological profile concurrent with clinical manifestations in goats, and hence can be used to assess the severity of the disease.

Clinical Significance of Cryofibrinogenemia: Possible Pathophysiological Link with Raynaud’s Phenomenon

2011 ◽  
Vol 39 (1) ◽  
pp. 119-124 ◽  
Author(s):  
MUHAMMAD S. SOYFOO ◽  
AHMED GOUBELLA ◽  
ELIE COGAN ◽  
JEAN-CLAUDE WAUTRECHT ◽  
ANNICK OCMANT ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Raynaud's Phenomenon ◽  
Clinical Findings ◽  
University Hospital ◽  
Significant Difference ◽  
Primary Raynaud’S Phenomenon ◽  
The Mean ◽  
Mean Concentration

Objective.To describe the clinical findings and prevalence of patients with cryofibrinogenemia (CF) and to determine whether CF is associated with primary Raynaud’s phenomenon.Methods.Between June 2006 and December 2009, 227 patients were tested for CF in a single university hospital. Forty-five patients with primary Raynaud’s phenomenon were tested for CF.Results.A total of 117 patients with CF without cryoglobulinemia were included. The main clinical manifestations included skin manifestations (50%) and arthralgia (35%). There were 67 patients with primary CF and 50 patients with secondary CF. There was no significant difference in the mean concentration of the cryoprecipitate in primary CF as compared to the secondary form (172 ± 18.6 vs 192 ± 20.9 mg/dl, respectively; p = 0.41). Highest concentrations of cryoprecipitate were observed in those containing fibrinogen only as compared to cryoprecipitates containing fibrinogen and fibronectin (301 ± 43.5 vs 125 ± 10.6 mg/dl; p < 0.001). Patients having skin necrosis (n = 3) had significantly higher values of cryofibrinogen compared to those without necrosis (638 ± 105 vs 160 ± 10.2 mg/dl; p = 0.0046). Among the 45 patients with primary Raynaud’s phenomenon, 36 had associated CF. There was no significant difference in the mean concentration of the cryoprecipitate in these patients compared to those with primary CF.Conclusion.There seems to be a significant correlation between cryofibrinogen concentration and the severity of the clinical signs, particularly when cryoprecipitate is composed of fibrinogen alone. CF might have a possible pathophysiological role in primary Raynaud’s phenomenon.

scholarly journals Epidemiological and Clinical Characteristics of Patients with COVID-19 in Arak, Iran

2020 ◽  
Vol 13 (1) ◽  
pp. 712-717
Author(s):  
Morteza Mousavi-Hasanzadeh ◽  
Hossein Sarmadian ◽  
Fatemeh Safi ◽  
Mohammad Jamalian ◽  
Amir Almasi-Hashiani
Keyword(s):  
Clinical Characteristics ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Case Fatality ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Mean ◽  
Mixed Ground ◽  
Taste And Smell ◽  
Muscle Ache

Background: The number of confirmed cases of COVID-19 is increasing. Here we present the clinical characteristics and outcomes of COVID-19 in Arak, Iran. Methods: In this study, 139 COVID-19 confirmed cases from 15 February to 15 March 2020 in Arak, Iran, were investigated. The clinical signs, symptoms, laboratory and radiological findings and outcomes were analyzed. Results: The mean age of the patients was 55.41 years (S.D.: 17.11) and 55.40% of them were males. 26.81% of patients had recently traveled to other epidemic cities. The most common clinical manifestations were fever (71.64%), cough (67.16%), shortness of breath (55.22%), muscle ache (50.00%) and the most prevalent complications were taste and smell disruption (29.5%), weakness (22.3%), anorexia (20.1%) and acute respiratory distress syndrome (ARDS) (15.8%). Almost half of the patients had lymphopenia, an elevated level of erythrocyte sedimentation rate (ESR) and C - reactive protein (CRP). In terms of outcome, 9.3% of patients needed an ICU admission as a result of ARDS in which 15.32% were directly admitted to the ICU. 43.2% of patients have been discharged and the case fatality rate (CFR) was estimated as 11.5%. Conclusion: COVID-19 pneumonia usually occurred at an age older than 50 years and in the male gender. The most common initial clinical laboratories and radiological presentations are fever, cough, lymphopenia with elevated CRP and ESR and Bilateral mixed ground-glass opacities with consolidation.

scholarly journals Review on Epidemiology, Control and Public Health Importance of Bovine Fasciolosis

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Feyisa TT ◽  
Keyword(s):  
Public Health ◽  
Life Cycle ◽  
Intermediate Host ◽  
Bile Ducts ◽  
Fasciola Hepatica ◽  
Previous History ◽  
Clinical Signs ◽  
Farm Animals ◽  
Economic Losses ◽  
Public Health Importance

Fascioliasis is a trematode zoonotic snail-borne disease of public health and economic importance. Fasciolosis is a parasitic disease that affects most population of cattle and it exists in almost all parts of the world. It is caused by commonly known species of liver fluke that are Fasciola hepatica and Fasciola gigantica, which mainly affects domestic ruminants. Fasciolosis is more apparent in young cattle and is usually chronic in nature. Adult flukes in the bile ducts cause inflammation, biliary obstruction, distraction of liver tissue and anemia. Fasciolosis is the major burden for Animal production and by direct or indirect economic losses at different part of our country. Diagnosis of fasciolosis is based primarily on clinical signs and seasonal occurrence in endemic areas but previous history of fasciolosis on the farm or identification of snail habitats; postmortem examinations, hematological tests and examination of faeces for fluke eggs are useful. The life cycle of Fasciola spp. is a typical of digenetic treamatodes. Eggs laid by the adult parasite in the bile ducts of their hosts pass into the duodenum with the bile. The life cycle of Fasciola goes through the intermediate host and several developmental stages in the intermediate host. On a herd basis, clinical signs of fluke infection are usually vague (i.e., reduced productivity) and can be difficult to differentiate from the effects of less-thanoptimal management or other chronic disease conditions. Transmission of fasciolosis infection is depending on the presence of “lymnea snail”, host and final host. Among many parasitic problems of farm animals, fasciolosis is a major disease which imposes economic impact on livestock production particularly of cattle and sheep and it has public health importance as it have zoonotic value.

scholarly journals Induced Neurocysticercosis in Rhesus Monkeys (Macaca mulatta) Produces Clinical Signs and Lesions Similar to Natural Disease in Man

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
N. Chowdhury ◽  
A. Saleque ◽  
N. K. Sood ◽  
L. D. Singla
Keyword(s):  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Epileptic Seizures ◽  
Cognitive Responses ◽  
Chronic Inflammatory Response ◽  
Experimental Animal Models ◽  
Liquefactive Necrosis ◽  
The Brain

Neurocysticercosis is a serious endemic zoonosis resulting in increased cases of seizure and epilepsy in humans. The genesis of clinical manifestations of the disease through experimental animal models is poorly exploited. The monkeys may prove useful for the purpose due to their behavior and cognitive responses mimicking man. In this study, neurocysticercosis was induced in two rhesus monkeys each with 12,000 and 6,000 eggs, whereas three monkeys were given placebo. The monkeys given higher dose developed hyperexcitability, epileptic seizures, muscular tremors, digital cramps at 10 DPI, and finally paralysis of limbs, followed by death on 67 DPI, whereas the monkeys given lower dose showed delayed and milder clinical signs. On necropsy, all the infected monkeys showed numerous cysticerci in the brain. Histopathologically, heavily infected monkeys revealed liquefactive necrosis and formation of irregular cystic cavities lined by atrophied parenchymal septa with remnants of neuropil of the cerebrum. In contrast, the monkeys infected with lower dose showed formation of typical foreign body granulomas characterized by central liquefaction surrounded by chronic inflammatory response. It was concluded that the inflammatory and immune response exerted by the host against cysticerci, in turn, led to histopathological lesions and the resultant clinical signs thereof.

scholarly journals Evaluation of Selected Outcomes of Combination Antiretroviral Therapy: Yemen Cohort Retrospective Descriptive Studies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mayada Faisal Nabih ◽  
Sharifa Ezat Wan Puteh ◽  
Amrizal Muhammad Nur
Keyword(s):  
Public Health ◽  
Treatment Outcomes ◽  
Retention Rate ◽  
Clinical Manifestations ◽  
Hiv Treatment ◽  
Female Ratio ◽  
Treatment Services ◽  
Male Female Ratio ◽  
Poor Treatment ◽  
The Mean

AbstractIn 2007, HIV treatment services were established in five main governorates out of twenty-two which resulted in low access to services and poor treatment outcomes. The main goal of this study was to evaluate and analyse the selected treatment outcomes of eight cohorts of PLHIV who were treated with cART during 2007–2014. The method used was a retrospective descriptive study of 1,703 PLHIV who initiated cART at five public health facilities. The results: Retention rate was less than 80%, male: female ratio 1.661, with a mean age of 35 years (±9.2 SD), 85% had been infected with HIV via heterosexual contact. 65% of patients presented with clinical stages 3 and 4, and 52% of them were initiated cART at a CD4 T-cell count ≤200 cells/mm. 61% of cART included Tenofovir and Efavirenz. TB treatment started for 5% of PLHIV, and 22% developed HIV-related clinical manifestations after cART initiation. 67% of PLHIV had experienced cART substitution. The mean AIDS-mortality rate was 15% and the mean LTFU rate was 16%. Conclusion: Although cART showed effectiveness in public health, mobilization of resources and formulation of better health policies are important steps toward improving access to cART and achieving the desired treatment outcomes.

scholarly journals Dengue fever and chikungunya virus infections: identification in travelers in Uganda – 2017

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
John T. Kayiwa ◽  
Annet M. Nankya ◽  
Irene Ataliba ◽  
Charity A. Nassuna ◽  
Isaac E. Omara ◽  
...  
Keyword(s):  
Public Health ◽  
Dengue Fever ◽  
Chikungunya Virus ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Final Diagnosis ◽  
Differential Diagnoses ◽  
Global Public Health ◽  
Emerging Viruses ◽  
Public Health Importance

AbstractArboviruses are (re-) emerging viruses that cause significant morbidity globally. Clinical manifestations usually consist of a non-specific febrile illness that may be accompanied by rash, arthralgia and arthritis and/or with neurological or hemorrhagic syndromes. The broad range of differential diagnoses of other infectious and non-infectious etiologies presents a challenge for clinicians. While knowledge of the geographic distribution of pathogens and the current epidemiological situation, incubation periods, exposure risk factors and vaccination history can help guide the diagnostic approach, the non-specific and variable clinical presentation can delay final diagnosis. This case report summarizes the laboratory-based findings of three travel-related cases of arbovirus infections in Uganda. These include a patient from Bangladesh with chikungunya virus infection and two cases of dengue fever from Ethiopia. Early detection of travel-imported cases by public health laboratories is important to reduce the risk of localized outbreaks of arboviruses such as dengue virus and chikungunya virus. Because of the global public health importance and the continued risk of (re-) emerging arbovirus infections, specific recommendations following diagnosis by clinicians should include obtaining travel histories from persons with arbovirus-compatible illness and include differential diagnoses when appropriate.

scholarly journals Clinical manifestations and hematological and serological findings in children with dengue infection

2011 ◽  
Vol 51 (3) ◽  
pp. 157 ◽  
Author(s):  
Mulya Rahma Karyanti
Keyword(s):  
Public Health ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Dengue Shock Syndrome ◽  
Signs And Symptoms ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
The Mean ◽  
Serological Data

Background Dengue hemorrhagic fever (DHF) is endemic to Indonesia and remains a public health problem, with its highest incidence in children. There have been few reports on the clinical, hematological and serological data in children \\lith dengue.Objective To assess the clinical and laboratory profiles of children \\lith dengue infection in Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Methods Clinical, hematological and serological infonnation from children diagnosed v.ith dengue infection in Cipto Mangunkusumo Hospital were collected from 2007 to 2009.Results Of611 children admitted with dengue, 143 (23.4%) had dengue fever (DF), 252 (41.2%) had DHF grades I and II; and 216 (35.4%) had DHF grades III and IV. Of the 81 cases where dengue serotypes were identified, 12.3% were DENV1, 35.8% were DENV-2, 48.2% were DENV-3 and 3.7% were DENV-4. Mean age of subjects was 8.9 years (SD 4.4), and 48.4% of cases were boys. The mean length of fever before hospital admission was 4.2 days (SD 1.1) and mean length of stay in the hospital was 4 days (SD 2.7). Common symptoms observed were petechiae, hepatomegaly and epistaxis. Complications found mostly in those with dengue shock syndrome (DSS) were hematemesis (30 cases, 4.9% of all patients), encephalopathy (19 cases, 3.1 %) and melena (17 cases, 2.8%).Conclusion Signs and symptoms of fever, bleeding manifestations and thrombocytopenia were present in children 'With DF and DHF, while signs of increased vascular permeability were found only in those 'With DHF. Encephalopathy and gastrointestinal bleeding were found mostly in DSS cases. At admission, leukopenia was found in more DF patients than in DHF patients. Absence of leukopenia may be a sign of more severe dengue infection. 

scholarly journals Listeriosis in Spain based on hospitalisation records, 1997 to 2015: need for greater awareness

2019 ◽  
Vol 24 (21) ◽  
Author(s):  
Zaida Herrador ◽  
Alin Gherasim ◽  
Rogelio López-Vélez ◽  
Agustín Benito
Keyword(s):  
Public Health ◽  
Public Health Problem ◽  
Risk Groups ◽  
Safety Education ◽  
Public Health Importance ◽  
Food Safety Education ◽  
The North ◽  
Food Borne ◽  
Increasing Trend ◽  
The Mean

Introduction Listeriosis is a food-borne disease of public health importance that has recently been involved in prolonged outbreaks. Despite its relevance, listeriosis is under-reported in many European countries. Aim We aimed to describe listeriosis epidemiology in Spain from 1997–2015. Methods We performed a retrospective study using the Spanish hospitalisation database. We calculated the mean number of hospitalisations per year and region. Pregnancy and neonatal-related listeriosis rates were computed. Relation between death and the presence of underlying health conditions was explored. Results Between 1997–2015, 5,696 listeriosis hospitalisations occurred, showing a constantly increasing trend. Higher hospitalisation rates were located in the north of the country compared to southern regions. The age group ≥ 65 years old was the most represented (50%). Pregnant women and newborns accounted for 7% and 4% of hospitalisations, respectively. An underlying immunocompromising condition was present in 56.4% of patients: cancer (22.8%), diabetes mellitus (16.6%) and chronic liver disease (13.1%). Death occurred in 17% of patients, more frequently among those ≥ 65 years old (67.5%), with sepsis (39.9%) or with meningoencephalitis (19.2%). Conclusion Listeriosis is an emergent public health problem in Spain that calls for targeted action. Further prevention strategies are urgently needed, including food safety education and messaging for all at-risk groups.

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