Serum lipids, arterial blood pressure and body weight in relation to the menopause: results from a population study of women in Goteborg, Sweden

To determine under resting, unstressed conditions the circulating glucocorticoid concentrations that best maintain sensitivity of the vascular smooth muscle and baroreceptor responses to vasoactive agents, rats with vascular cannulas were sham-adrenalectomized (sham) or adrenalectomized (ADRX) and provided with four levels of corticosterone replacement (approximately 100 mg fused pellets of corticosterone: cholesterol 0, 20, 40, and 80% implanted subcutaneously at the time of adrenal surgery). Changes in vascular and baroreflex responses were determined after intravenous injection of varying doses of phenylephrine and nitroglycerin with measurement of arterial blood pressure and heart rate in the conscious, chronically cannulated rats. Vascular sensitivity was decreased, and resting arterial blood pressure tended to be decreased in the adrenalectomized rats; both were restored to normal with levels of corticosterone (40%), which also maintained body weight gain, thymus weight, and plasma corticosteroid binding globulin concentrations at normal values. The baroreflex curve generated from the sham group was different from the curves generated from the ADRX+0, 20, and 40% groups, but not different from that of the ADRX+80% group, suggesting that the baroreflex is maintained by higher levels of corticosterone than are necessary for the maintenance of the other variables. These data demonstrate that physiological levels of corticosterone (40% pellet) restore vascular responsiveness, body weight, thymus weight, and transcortin levels to normal in ADRX rats, whereas higher levels (80% pellet) are necessary for restoration of the baroreflex.

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Serum lipids and arterial blood pressure in relation to waist-to-hip ratio in young males

American Journal of Clinical Nutrition ◽

10.1093/ajcn/57.5.697 ◽

1993 ◽

Vol 57 (5) ◽

pp. 697-698 ◽

Cited By ~ 1

Author(s):

N Katsilambros ◽

E Georgiadis ◽

C Aliferis ◽

L Papandreou ◽

D Triantaphyllou ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

Serum Lipids ◽

Waist To Hip Ratio ◽

Young Males ◽

Arterial Blood

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ARTERIAL BLOOD PRESSURE SERUM LIPIDS AND CARDIOVASCULAR COMPLICATIONS IN FAMILIES OF HYPERTENSIVE CHILDREN

Acta Paediatrica ◽

10.1111/j.1651-2227.1982.tb09406.x ◽

1982 ◽

Vol 71 (2) ◽

pp. 235-238 ◽

Cited By ~ 2

Author(s):

CHR. CASSIMOS ◽

V. AIVAZIS ◽

S. KARAMPERIS ◽

G. VARLAMIS ◽

V. KATSOUYANNOPOULOS

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

Serum Lipids ◽

Cardiovascular Complications ◽

Arterial Blood

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Arterial blood pressure and serum lipids in a population of children and adolescents from Southern Italy: The Calabrian Sierras Community Study (CSCS)

International Journal of Cardiology ◽

10.1016/j.ijcard.2012.11.045 ◽

2013 ◽

Vol 168 (2) ◽

pp. 1108-1114 ◽

Cited By ~ 14

Author(s):

Francesco Martino ◽

Paolo Emilio Puddu ◽

Giuseppe Pannarale ◽

Chiara Colantoni ◽

Cristina Zanoni ◽

...

Keyword(s):

Blood Pressure ◽

Children And Adolescents ◽

Arterial Blood Pressure ◽

Serum Lipids ◽

Southern Italy ◽

Community Study ◽

Arterial Blood

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SKIN–FOLD THICKNESS IN RELATION TO BODY WEIGHT AND ARTERIAL BLOOD PRESSURE

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1962.tb19919.x ◽

1962 ◽

Vol 2 (1) ◽

pp. 13-15 ◽

Cited By ~ 13

Author(s):

G. Palmai

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Arterial Blood Pressure ◽

Skin Fold Thickness ◽

Arterial Blood ◽

Skin Fold

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Exaggerated natriuresis during clamping of systemic NO supply in healthy young men

Clinical Science ◽

10.1042/cs20110144 ◽

2011 ◽

Vol 122 (2) ◽

pp. 63-73 ◽

Cited By ~ 5

Author(s):

Jane A. Simonsen ◽

Mona S. Rasmussen ◽

Werner Vach ◽

Poul F. Høilund-Carlsen ◽

Peter Bie

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Arterial Blood Pressure ◽

Sodium Excretion ◽

Volume Expansion ◽

Renal Plasma Flow ◽

Peripheral Resistance ◽

Young Men ◽

System Activity ◽

Arterial Blood

NO (nitric oxide) may be involved in fluid homoeostasis. We hypothesized that increases in NO synthesis contribute to acute, saline-induced natriuresis, which, therefore, should be blunted when NO availability is stabilized. Young men were studied during simultaneous infusions of L-NAME [NG-nitro-L-arginine methyl ester; bolus of 750 μg·kg−1 of body weight and 8.3 μg·min−1·kg−1 of body weight] and SNP (sodium nitroprusside), the latter at a rate preventing L-NAME from increasing total peripheral resistance (‘NO-clamping’). Slow volume expansion (saline, 20 μmol of NaCl·min−1·kg−1 of body weight for 3 h) was performed with and without concomitant NO-clamping. NO-clamping itself decreased RPF (renal plasma flow; P~0.02) and tended to decrease arterial blood pressure [MABP (mean arterial blood pressure)]. Volume expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P<0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p-aminohippurate), GFR [glomerular filtration rate; by using 51Cr-labelled EDTA] and plasma [Na+] and [K+] remained constant. Volume expansion increased sodium excretion (P<0.02) at constant filtered load, but more so during NO-clamping than during control (+184% compared with 52%; P<0.0001). Urinary nitrate/nitrite excretion increased during volume expansion; plasma cGMP and plasma vasopressin were unchanged. The results demonstrate that NO-clamping augments sodium excretion in response to volume expansion at constant MABP and GFR, reduced RPF and decreased renin system activity, a response termed hypernatriuresis. The results indicate that mediator(s) other than MABP, RPF, GFR and renin system activity contribute significantly to the homoeostatic response to saline loading, but the specific mechanisms of hypernatriuresis remain obscure.

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The physiological significance of body weight at birth for subsequent age periods of life

Kazan medical journal ◽

10.17816/kmj2323 ◽

2012 ◽

Vol 93 (2) ◽

pp. 330-334

Author(s):

Yu D Karpenko

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Birth Weight ◽

Arterial Blood Pressure ◽

Random Variable ◽

The Body ◽

Examination Period ◽

Arterial Blood ◽

Cardio Vascular ◽

Birth Body Weight

Aim. To study the significance of the features of early development of a child’s body, estimated on the basis of the anthropometric data at birth for subsequent age periods. Methods. The study involved practically healthy 1-5 year students with normal birth weight, 439 males and 112 females, mean age was 21.13±±0.08 years. Measurements of systolic and diastolic arterial blood pressure were performed using an automated tonometer, heart rate variability was studied on a computer electrocardiography device in accordance with the generally accepted guidelines. Conducted was a multiple regression analysis, in which as an independent random variable were the age and height of the mother, the sex of the newborn, the serial number of delivery, and as a dependent variable - the birth body weight. Results. Established was a significant correlation between birth body weight and body length (β=0.163; p=0.000), maternal age (β=0.137; p=0.001), month (season) of birth (β=-0.2012; p=0.003) and sex (β=-0.1009; p=0.003) of the child. Noted was a correlation of the respiration rate with the body weight at birth both during the semester period (r=-0.2; p=0.05) and during the examination period (r=0.26; p=0.03). Conclusion. During the examination period the correlation between birth weight and the values of functional parameters (respiratory rate, tidal volume, arterial blood pressure) of the students increases, therefore, birth body weight among the surveyed students was a predictor of the functional state of the respiratory system, cardio-vascular and autonomic nervous systems.

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Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats

PeerJ ◽

10.7717/peerj.11110 ◽

2021 ◽

Vol 9 ◽

pp. e11110

Author(s):

Reham Z. Hamza ◽

Abdel Aziz A. Diab ◽

Mansour H. Zahra ◽

Ali K. Asalah ◽

Mai S. Attia ◽

...

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Arterial Blood Pressure ◽

Mean Arterial Blood Pressure ◽

Histopathological Examination ◽

Female Rats ◽

Serum Urea ◽

Pregnant Rats ◽

Arterial Blood ◽

Total Urine

Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria. Thirty-three pregnant female rats were divided into three groups; group: 1 (normal pregnant rats), group: 2 (preeclamptic rats); where rats were injected subcutaneously with 75 mg L-NAME/ kg body weight/day beginning from 9th to 20th day of pregnancy andgroup 3 (apelin-13 treated preeclamptic rats); In which L-NAME-induced preeclamptic rats were subcutaneously injected with 6 × 10−8 mol apelin-13/kg body weight/twice daily starting from 6th to 20th day of pregnancy. In all groups, mean arterial blood pressure, total urine protein, serum urea, creatinine, nitric oxide (NO), endothelin-1 (ET-1), interleukin–6 (IL-6) and malondialdhyde (MDA) were measured. Histopathological examination of kidney tissues was also done. preeclamptic rats showed significantly increased mean arterial blood pressure, total urine proteins, serum urea, creatinine, ET-1, IL-6, and MDA, but revealed a significantly decreased serum NO level. On the other hand, apelin treatment significantly improved these parameters together with amelioration of kidney histoarchitecture in the treated group. In conclusion, apelin may be a potentially curative candidate for prohibiting kidney damage and have a therapeutic benefit in PE rat models.

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