LRP::FLAG Reduces Phosphorylated Tau Levels in Alzheimer’s Disease Cell Culture Models

2020 ◽  
pp. 1-16
Author(s):  
Katelyn Cuttler ◽  
Monique J. Bignoux ◽  
Tyrone C. Otgaar ◽  
Stephanie Chigumba ◽  
Eloise Ferreira ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Phosphorylated Tau ◽  
Culture Models ◽  
Cell Culture Models ◽  
Disease Cell

scholarly journals Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang Su Kwak ◽  
Kevin J. Washicosky ◽  
Emma Brand ◽  
Djuna von Maydell ◽  
Jenna Aronson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Neural Cell ◽  
Tau Pathology ◽  
Culture Models ◽  
Cell Culture Models ◽  
Human Neural Cell

scholarly journals LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8556 ◽  
Author(s):  
Jose F. Abisambra ◽  
Tina Fiorelli ◽  
Jaya Padmanabhan ◽  
Peter Neame ◽  
Inge Wefes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Human Cell ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease

2021 ◽  
Author(s):  
Pascal-L. Stahr ◽  
Rekha Grewal ◽  
Gunter P. Eckert ◽  
Cornelia M. Keck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Dissolution Rate ◽  
Aqueous Solubility ◽  
Prevention And Treatment ◽  
Culture Models ◽  
Poorly Soluble ◽  
Kinetic Solubility ◽  
Cell Culture Models

Abstract Poor aqueous solubility of drug substances is associated with poor bioavailability and thus hampers the effective use of many potent active pharmaceutical ingredients. Various strategies to overcome poor solubility are available, whereby drug nanocrystals represent one of the most powerful formulation strategies to enhance the kinetic solubility and dissolution rate of poorly soluble drugs. Nanocrystals are simply obtained by milling large-sized drug powders to sizes < 1 µm. The so obtained nanocrystals possess an increased dissolution rate and kinetic solubility when compared with larger-sized bulk material. The aim of this study was to produce differently sized hesperetin nanocrystals and to investigate the influence of nanocrystal size on the bioefficacy of the natural antioxidant hesperetin in two cell culture models for the prevention and treatment of Alzheimer’s disease. Results showed that the testing of poorly soluble compounds is challenging and requires incredibly careful characterization. Reasons for this are possible changes of the formulations in cell culture media which can occur due to various reasons. If the changes are not considered, results obtained can be misleading and even lead to a false interpretation of the results obtained. Besides, results demonstrate the increase in dissolution rate with decreasing particle size that is especially pronounced with particle sizes < 200 nm. Data also provide clear evidence that smaller nanocrystals with higher kinetic solubility possess higher antioxidant capacity. This results in lower amounts of free radicals in the cell culture models, suggesting that hesperetin nanocrystals, that improve the poor aqueous solubility of hesperetin, are promising for the prevention and treatment of Alzheimer’s disease. Graphical abstract "Image missing"

Beneficial Effects of Sideritis scardica and Cichorium spinosum against Amyloidogenic Pathway and Tau Misprocessing in Alzheimer’s Disease Neuronal Cell Culture Models

2018 ◽  
Vol 64 (3) ◽  
pp. 787-800 ◽  
Author(s):  
Ioanna Chalatsa ◽  
Demetrios A. Arvanitis ◽  
Eleni V. Mikropoulou ◽  
Athina Giagini ◽  
Zeta Papadopoulou-Daifoti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Neuronal Cell ◽  
Neuronal Cell Culture ◽  
Beneficial Effects ◽  
Culture Models ◽  
Cell Culture Models

Integrated paper-based 3D platform for long-term cell culture and in situ cell viability monitoring of Alzheimer's disease cell model

Talanta ◽  
2021 ◽  
Vol 223 ◽  
pp. 121738
Author(s):  
Meng-Meng Liu ◽  
Hui Liu ◽  
Shan-Hong Li ◽  
Yu Zhong ◽  
Yao Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Cell Viability ◽  
Cell Model ◽  
Disease Cell

scholarly journals A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

2020 ◽  
Vol 14 ◽  
Author(s):  
Mercedes A. Hernández-Sapiéns ◽  
Edwin E. Reza-Zaldívar ◽  
Ricardo R. Cevallos ◽  
Ana L. Márquez-Aguirre ◽  
Karlen Gazarian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Three Dimensional ◽  
Cell Culture Model ◽  
Culture Model ◽  
Disease Cell
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