scholarly journals Infantile Hemangiomas: An Update on Pathogenesis and Treatment

2021 ◽  
Vol 10 (20) ◽  
pp. 4631
Author(s):  
Małgorzata Kowalska ◽  
Wojciech Dębek ◽  
Ewa Matuszczak
Keyword(s):  
Current Knowledge ◽  
Combined Therapy ◽  
Natural Course ◽  
Vascular Tumors ◽  
Treatment Methods ◽  
Indications For Treatment ◽  
Active Observation ◽  
Insufficient Response ◽  
Basic Treatment

Infantile hemangiomas are the most common benign vascular tumors in infancy. This review includes an update on the current knowledge on pathogenesis, a discussion on indications for treatment, and a review of the mechanisms underlying the different treatment methods. Although most infantile hemangiomas require only active observation because of their natural course, which results in involution, about 10% present with complications that require immediate treatment. The basic treatment includes systemic and topical options. In cases of insufficient response or rebound growth, other forms of treatment should be considered. In some cases, combined therapy might be initiated.

scholarly journals Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders

2009 ◽  
Vol 11 (1) ◽  
pp. 45-62 ◽  
Keyword(s):  
Children And Adolescents ◽  
Depressive Disorders ◽  
Current Knowledge ◽  
Unipolar Depression ◽  
Depressive Illness ◽  
Developmental Differences ◽  
Natural Course ◽  
Response To Treatment ◽  
Childhood And Adolescence ◽  
Full Potential

Depressive illness beginning early in life can have serious developmental and functional consequences. Therefore, understanding the disorder during this developmental stage is critical for determining its etiology and course, as well as for developing effective intervention strategies. This paper summarizes current knowledge regarding the etiology, phenomenology, correlates, natural course, and consequences of unipolar depression in children and adolescents. Using adult depression as a framework, the unique aspects of childhood and adolescence are considered in order to better understand depression within a developmental context. The data suggest that the clinical presentation, correlates, and natural course of depression are remarkably similar across the lifespan. There are, however, important developmental differences. Specifically, the familial and psychological context in which depression develops in youngsters is associated with variability in the frequency and nature of depressive symptoms and comorbid conditions among children and adolescents. Maturational differences have also been identified in the neurobiological correlates of depression. These developmental differences may be associated with the observed variability in clinical response to treatment and longitudinal course. Characterization of the developmental differences will be helpful in developing more specific and effective interventions for youngsters, thereby allowing them to reach their full potential as adults.

scholarly journals The history of melanoma diagnostics

2021 ◽  
Vol 9 (3) ◽  
pp. 132-137
Author(s):  
Paula Kamińska ◽  
Karolina Buszka ◽  
Michał Nowicki ◽  
Joanna Budna-Tukan
Keyword(s):  
Current Knowledge ◽  
Diagnostic Methods ◽  
Therapeutic Management ◽  
Historical Overview ◽  
Circulating Tumour Cells ◽  
Laboratory Methods ◽  
Treatment Methods ◽  
Historical Outline ◽  
History Of

Abstract This article provides a historical overview of melanoma, involving the knowledge of this neoplasm from antiquity to the present. Selected people who made key descriptions of the disease, its symptoms, and treatment methods were listed. The classification of melanoma, which is used in therapeutic management nowadays, is briefly discussed. Additionally, we describe circulating tumour cells and the selected diagnostic methods associated with their detection and characteristics. The aim of this article is to present a historical outline of melanoma, as well as its classification and the development of laboratory methods of its diagnosis. In addition, we have also provided a comparison of historical and current knowledge of this malignancy.

scholarly journals Application of derinat and titanium glycerosolvate aquacomplex in treatment of destructive forms of erysipelas

2017 ◽  
Vol 176 (6) ◽  
pp. 71-75
Author(s):  
E. A. Brazhnik ◽  
A. A. Glukhov ◽  
M. V. Aralova
Keyword(s):  
Immune System ◽  
Soft Tissues ◽  
Combined Therapy ◽  
Treatment Results ◽  
Fourth Group ◽  
The Third ◽  
Purulent Wounds ◽  
Efficacy Of Treatment ◽  
Basic Treatment ◽  
Regeneration Processes

OBJECTIVE. The authors researched the ways of improvement of treatment results in patients with complicated forms of erysipelas. MATERIAL AND METHODS. There were examined 68 patients with erysipelas complicated by abscess, phlegmon or necrosis of soft tissues. Basic treatment was used for the first group of patients. Combination of basic treatment and application of titanium glycerosolvate aquacomplex were carried out in the second group. Basic treatment and immunomodulator Derinat were applied in the third group. Combined therapy including titanium glycerosolvate aquacomplex and Derinat was used in the fourth group. RESULTS. Prescription of Derinat for patients with erysipelas allowed doctors to eliminate symptoms of general intoxication in more earlier terms compared with сonventional treatment. The application of Derinat stimulated T-and B-сomponents of immune system. The local application of Tizol facilitated to earlier decrease of inflammation and it stimulated regeneration processes in the wound. CONCLUSIONS. The therapy of destructive forms of erysipelas which included Derinat and Tizol shortened the terms of cleansing and repair of purulent wounds. This method increased the efficacy of treatment of given class of patients.

scholarly journals Clinical and electromyographic evaluation of the effectiveness of the use of interference currents and traction therapy in the treatment of patients with vertebral radiculopathy

2020 ◽  
Vol 19 (6) ◽  
pp. 384-390
Author(s):  
Parvis Yа. Akhundov ◽  
Sadagat G. Huseynova
Keyword(s):  
Compound Muscle Action Potential ◽  
Combined Therapy ◽  
Life Quality ◽  
Pain Syndrome ◽  
Control Group ◽  
Complex Treatment ◽  
Treatment Methods ◽  
Rehabilitative Treatment ◽  
Combined Use

Background. Relevance of elaboration of lumbosacral radiculopathy (LSR) treatment methods is сonditioned by widespread of this pathology. Pain syndrome (PS) reducing activity and life quality of workable patients is the most prevailing clinical manifestation of this disease. Сonservative treatment methods of LSR directed to decrease pain, oedema and compression of nerve roots as well as contributing to сonductivity improvement include medication, physiotherapeutic and orthopaedic treatment. Aims: Clinical neurophysiological justification of combined use of interference therapy (IT) and spine traction (ST) in complex treatment of vertebral LSR. Materials and methods. The first-control group (n=32) who were treated by using ST as a treatment. The second ― treatment group (n=32) included those who were treated by using the IT and ST on the same day. All patients had radicular syndromes. All patients passed the lumbar MRI scan. PS was estimated according to the visual-analogic scale (VAS) and McGills questionnaire. Estimation of life quality of patients was based on Roland-Morris questionnaire. Electromyography registered dynamics of impulse conduction on motor fibres, as well as parametеrs of compound muscle action potential and H-reflex. Results. Positive effect of combined use of interference therapy with spine traction in complex treatment of vertebral radiculopathy patients are proved. It has been established that the therapeutic effect of the complex application of IT and ST lies in the improvement in the afferent and efferent links of the neuromotor apparatus, as well as the functional state of the spinal alpha-motoneurons associated with the acceleration of the regenerative processes. Conclusion. Results of the clinical neurophysiological investigation, carried out before and after rehabilitative treatment allow to recommend combined therapy of IT and ST for treatment of vertebral LSR.

scholarly journals A Review on Occurrence and Spread of Antibiotic Resistance in Wastewaters and in Wastewater Treatment Plants: Mechanisms and Perspectives

2021 ◽  
Vol 12 ◽  
Author(s):  
Cansu Uluseker ◽  
Krista Michelle Kaster ◽  
Kristian Thorsen ◽  
Daniel Basiry ◽  
Sutha Shobana ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Wastewater Treatment ◽  
Activated Sludge ◽  
Mathematical Models ◽  
Wastewater Treatment Plants ◽  
Current Knowledge ◽  
Treated Wastewater ◽  
Resistant Bacteria ◽  
Sludge Treatment ◽  
Treatment Methods

This paper reviews current knowledge on sources, spread and removal mechanisms of antibiotic resistance genes (ARGs) in microbial communities of wastewaters, treatment plants and downstream recipients. Antibiotic is the most important tool to cure bacterial infections in humans and animals. The over- and misuse of antibiotics have played a major role in the development, spread, and prevalence of antibiotic resistance (AR) in the microbiomes of humans and animals, and microbial ecosystems worldwide. AR can be transferred and spread amongst bacteria via intra- and interspecies horizontal gene transfer (HGT). Wastewater treatment plants (WWTPs) receive wastewater containing an enormous variety of pollutants, including antibiotics, and chemicals from different sources. They contain large and diverse communities of microorganisms and provide a favorable environment for the spread and reproduction of AR. Existing WWTPs are not designed to remove micropollutants, antibiotic resistant bacteria (ARB) and ARGs, which therefore remain present in the effluent. Studies have shown that raw and treated wastewaters carry a higher amount of ARB in comparison to surface water, and such reports have led to further studies on more advanced treatment processes. This review summarizes what is known about AR removal efficiencies of different wastewater treatment methods, and it shows the variations among different methods. Results vary, but the trend is that conventional activated sludge treatment, with aerobic and/or anaerobic reactors alone or in series, followed by advanced post treatment methods like UV, ozonation, and oxidation removes considerably more ARGs and ARB than activated sludge treatment alone. In addition to AR levels in treated wastewater, it examines AR levels in biosolids, settled by-product from wastewater treatment, and discusses AR removal efficiency of different biosolids treatment procedures. Finally, it puts forward key-points and suggestions for dealing with and preventing further increase of AR in WWTPs and other aquatic environments, together with a discussion on the use of mathematical models to quantify and simulate the spread of ARGs in WWTPs. Mathematical models already play a role in the analysis and development of WWTPs, but they do not consider AR and challenges remain before models can be used to reliably study the dynamics and reduction of AR in such systems.

scholarly journals The use of combination of fibrinolytic therapy and abciximab in the treatment of the acute myocardial infarction with ST elevation

2002 ◽  
Vol 59 (6) ◽  
pp. 675-680
Author(s):  
Branko Gligic ◽  
Dragan Dincic ◽  
Slobodan Obradovic ◽  
Milic Markovic ◽  
Vjekoslav Orozovic
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Current Knowledge ◽  
Systolic Function ◽  
Combined Therapy ◽  
Reperfusion Therapy ◽  
Fibrinolytic Therapy ◽  
Coronary Syndrome ◽  
Platelet Receptor ◽  
St Elevation

Background. According to current knowledge, the best way to treat the acute myocardial infarction with ST elevation is primary transluminal coronary angioplasty, which can be performed only in the best equipped tertiary cardiology centers. As it was known that atherothrombosis was the essence of the acute coronary syndrome we wanted to examine the efficacy and safety of combined therapy of tissue plasminogen activator and glycoprotein IIbIIIa platelet receptor antagonist abciximab. Methods. The case is reported of combined abciximab and accelerate schedule of t-PA reperfusion therapy in a young patient with the extensive anterior acute myocardial infarction. Activated partial thromboplastin time and platelet count were regularly measured during therapy. Results. The combination of these two drugs did not cause any complication in our patient. According to early noninvasive parameters, successful reperfusion was achieved. Postinfarction period was without complications. Coronary angiography was performed 15 days after and was without pathological findings. Eighteen months later the event patient had neither chest pain, nor other complaints with slightly reduced R waves in middle precordial leads and hypokinesis of anterior apical segment of the left ventricle showing the signs of important systolic function impairment. Conclusion. Controlled studies are needed to prove the safety and the benefit of such combined reperfusion therapy and to show which kind of treatment is appropriate in every case considering the patient conditions and the facilities of coronary care unit.

scholarly journals Current treatment methods for sarcopenia in patients undergoing hemodialysis

2018 ◽  
Vol 8 (2) ◽  
pp. 36-42
Author(s):  
Aleksandr A Jakovenko
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Combined Therapy ◽  
Ideal Body Weight ◽  
Treatment Method ◽  
Current Treatment ◽  
Adequate Intake ◽  
Essential Nutrients ◽  
Treatment Methods ◽  
Ideal Body

Aim. To evaluate the effectiveness of combined post-dilution online hemodiafiltration therapy and ketoanalogue amino acid medications at a dose of 0.2 g/kg of ideal body weight/day for sarcopenia-correcting interventions in patients on hemodialysis with adequate intake of essential nutrients. Materials and methods. In total, 645 patients undergoing hemodialysis were examined. Nutritional status of all patients was evaluated to identify pre-sarcopenia and sarcopenia. In addition, leptin and interleukin-6 serum levels were determined. The patients with signs of sarcopenia were divided into three groups depending on the treatment method. Results. We demonstrated the effectiveness of combined post-dilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day for correction of sarcopenia in patients on hemodialysis. Conclusion. Combined therapy with post-dilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day is regarded as a pathogenetically grounded method for correction of sarcopenia in patients on hemodialysis with adequate intake of essential nutrients. (For citation: Jakovenko AA. Current treatment methods for sarcopenia in patients undergoing hemodialysis. Urologicheskie vedomosti. 2018;8(2):36-42. doi: 10.17816/uroved8236-42).

Epidermoid Carcinoma of the Floor of the Mouth: Surgical Therapy vs Combined Therapy VS Radiation Therapy

1980 ◽  
Vol 88 (6) ◽  
pp. 714-720 ◽  
Author(s):  
William R. Panje ◽  
Bruce Smith ◽  
Brian F. McCabe
Keyword(s):  
Surgical Therapy ◽  
Combined Therapy ◽  
Epidermoid Carcinoma ◽  
Stage Iii ◽  
Disease Stage ◽  
Preoperative Radiation ◽  
Tumor Spread ◽  
Treatment Methods ◽  
Floor Of Mouth ◽  
Irradiation Therapy

A retrospective analysis of 103 selected patients with floor-of-mouth epidermoid carcinoma compared the effectiveness of surgical therapy alone vs planned preoperative radiation combined therapy vs irradiation therapy. All three treatment methods appeared equally effective in irradicating stage I and II disease. Stage III floor-of-mouth epidermoid carcinoma was similarly controlled by either surgical therapy or combined therapy. Irradiation therapy alone was markedly inferior in treatment of stage III disease. Stage IV disease was poorly handled by any of the treatment methods. Histologic factors, tumor characteristics, tumor spread, nodal status, and staging did not appear in the majority of cases to significantly influence treatment selection or survival or both.

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