scholarly journals Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 37
Author(s):  
Biswajita Pradhan ◽  
Rabindra Nayak ◽  
Srimanta Patra ◽  
Bimal Prasad Jit ◽  
Andrea Ragusa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bioactive Compounds ◽  
Marine Algae ◽  
Inflammatory Diseases ◽  
Bioactive Metabolites ◽  
Therapeutic Implications ◽  
Beneficial Effects ◽  
Synthetic Drugs ◽  
Photosynthetic Organisms ◽  
Leading Role

In addition to cancer and diabetes, inflammatory and ROS-related diseases represent one of the major health problems worldwide. Currently, several synthetic drugs are used to reduce oxidative stress; nevertheless, these approaches often have side effects. Therefore, to overcome these issues, the search for alternative therapies has gained importance in recent times. Natural bioactive compounds have represented, and they still do, an important source of drugs with high therapeutic efficacy. In the “synthetic” era, terrestrial and aquatic photosynthetic organisms have been shown to be an essential source of natural compounds, some of which might play a leading role in pharmaceutical drug development. Marine organisms constitute nearly half of the worldwide biodiversity. In the marine environment, algae, seaweeds, and seagrasses are the first reported sources of marine natural products for discovering novel pharmacophores. The algal bioactive compounds are a potential source of novel antioxidant and anticancer (through modulation of the cell cycle, metastasis, and apoptosis) compounds. Secondary metabolites in marine Algae, such as phenolic acids, flavonoids, and tannins, could have great therapeutic implications against several diseases. In this context, this review focuses on the diversity of functional compounds extracted from algae and their potential beneficial effects in fighting cancer, diabetes, and inflammatory diseases.

scholarly journals Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 459 ◽  
Author(s):  
Ji Kim ◽  
Jae-Eun Lee ◽  
Kyoung Kim ◽  
Nam Kang
Keyword(s):  
Bioactive Compounds ◽  
Marine Algae ◽  
Health Benefits ◽  
Value Added ◽  
Present Review ◽  
Beneficial Effects ◽  
Aging Properties ◽  
Cosmetic Formulations ◽  
Health Promoting ◽  
Thickening Agents

Marine algae are considered to be an abundant sources of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrates are the major and abundant constituent of marine algae and have been utilized in cosmetic formulations, as moisturizing and thickening agents for example. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for their various properties beneficial to skin, including antioxidant, anti-melanogenic and skin anti-aging properties. Therefore, marine algae carbohydrates have potential skin health benefits for value-added cosmeceutical applications. The present review focuses on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

scholarly journals Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes

2015 ◽  
Vol 20 (1) ◽  
Author(s):  
Margherita La Marca ◽  
Laura Pucci ◽  
Roberto Bollini ◽  
Rossella Russo ◽  
Francesca Sparvoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phaseolus Vulgaris ◽  
Bioactive Compounds ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Antioxidant Effect ◽  
Phaseolus Vulgaris L ◽  
Detoxifying Enzymes ◽  
Nrf2 Pathway ◽  
Beneficial Effects

AbstractThe role and beneficial effects of plant and food extracts against various diseases induced by oxidative stress have received much attention in recent years. Legumes are rich in bioactive compounds, and some studies suggest a correlation between their consumption and a reduced incidence of diseases. Primary cultures of rat hepatocytes were used to investigate whether and how an extract obtained from a fermented powder of bean named Lady Joy (Phaseolus vulgaris L.) is able to regulate antioxidant and detoxifying enzymes through the NRF2 pathway, inhibit NF-kB activation, and reduce H

scholarly journals Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

2018 ◽  
Author(s):  
Ji Hye Kim ◽  
Jae-Eun Lee ◽  
Kyoung Heon Kim ◽  
Nam Joo Kang
Keyword(s):  
Bioactive Compounds ◽  
Marine Algae ◽  
Health Benefits ◽  
Value Added ◽  
Skin Aging ◽  
Beneficial Effects ◽  
Cosmetic Formulations ◽  
Health Promoting ◽  
Anti Oxidant ◽  
Thickening Agents

Marine algae have been considered as abundant source of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrate is a major and abundant constitute of marine algae that have been utilized in cosmetic formulations, such as moisturizing and thickening agents. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for various skin beneficial properties, such as anti-oxidant, anti-melanogenic and anti-skin aging. Therefore, marine algae carbohydrates have potential of skin health benefits for value-added cosmeceutical application. The present review focused on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

Benefits of coffee consumption for human health: an overview

2022 ◽  
Vol 18 ◽  
Author(s):  
Jéssica Petrine Castro Pereira ◽  
Fernanda Aparecida Castro Pereira ◽  
Carlos José Pimenta
Keyword(s):  
Chlorogenic Acid ◽  
Human Health ◽  
Bioactive Compounds ◽  
Inflammatory Diseases ◽  
Coffee Consumption ◽  
Antimutagenic Activity ◽  
Organoleptic Properties ◽  
Beneficial Effects ◽  
High Antioxidant Activity

Background: Coffee is one of the most consumed beverages worldwide and is popular for its characteristic flavor and rich organoleptic properties. Aim: Based on published articles, the aims of this review are i) study the association between coffee consumption and benefits to human health; ii) the effects of coffee consumption on some pathologies; and iii) provide a description of coffee’s bioactive compounds. Discussion: Coffee presents bioactive compounds, which include phenolic compounds, especially chlorogenic acid (caffeoylquinic acid), trigonelline, and diterpenes, such as cafestol and kahweol. These compounds are related to the beneficial effects for human health, including high antioxidant activity, antimutagenic activity, hepatoprotective action, reduced incidence of type 2 diabetes mellitus, reduced risk of cardiovascular diseases, decreased incidence of inflammatory diseases, reduced menopausal symptoms, and others. Coffee’s bioactive compounds are caffeine, chlorogenic acid, trigonelline, cafestol and kahweol, which are closely related to coffee’s beneficial effects. Conclusion: The present review clarified that the benefits of moderate coffee consumption outweigh the associated risks.

scholarly journals Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging

Biology ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 30 ◽  
Author(s):  
Sunil J. Wimalawansa
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Systemic Inflammation ◽  
Aging Process ◽  
Inflammatory Diseases ◽  
Cost Effective ◽  
Hypovitaminosis D ◽  
Beneficial Effects ◽  
Age Related ◽  
Mitochondrial Functions

Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone, has beneficial effects on several body systems other than the musculoskeletal system. Both 25 dihydroxy vitamin D [25(OH)2D] and its active hormonal form, 1,25-dihydroxyvitamin D [1,25(OH)2D] are essential for human physiological functions, including damping down inflammation and the excessive intracellular oxidative stresses. Vitamin D is one of the key controllers of systemic inflammation, oxidative stress and mitochondrial respiratory function, and thus, the aging process in humans. In turn, molecular and cellular actions form 1,25(OH)2D slow down oxidative stress, cell and tissue damage, and the aging process. On the other hand, hypovitaminosis D impairs mitochondrial functions, and enhances oxidative stress and systemic inflammation. The interaction of 1,25(OH)2D with its intracellular receptors modulates vitamin D–dependent gene transcription and activation of vitamin D-responsive elements, which triggers multiple second messenger systems. Thus, it is not surprising that hypovitaminosis D increases the incidence and severity of several age-related common diseases, such as metabolic disorders that are linked to oxidative stress. These include obesity, insulin resistance, type 2 diabetes, hypertension, pregnancy complications, memory disorders, osteoporosis, autoimmune diseases, certain cancers, and systemic inflammatory diseases. Vitamin D adequacy leads to less oxidative stress and improves mitochondrial and endocrine functions, reducing the risks of disorders, such as autoimmunity, infections, metabolic derangements, and impairment of DNA repair; all of this aids a healthy, graceful aging process. Vitamin D is also a potent anti-oxidant that facilitates balanced mitochondrial activities, preventing oxidative stress-related protein oxidation, lipid peroxidation, and DNA damage. New understandings of vitamin D-related advances in metabolomics, transcriptomics, epigenetics, in relation to its ability to control oxidative stress in conjunction with micronutrients, vitamins, and antioxidants, following normalization of serum 25(OH)D and tissue 1,25(OH)2D concentrations, likely to promise cost-effective better clinical outcomes in humans.

scholarly journals Protective Effects of SPA0355, a Thiourea Analogue, Against Lipopolysaccharide-Induced Acute Kidney Injury in Mice

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 585 ◽  
Author(s):  
Jung-Yeon Kim ◽  
Jaechan Leem ◽  
Hyo-Lim Hong
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Cell Apoptosis ◽  
Immune Cell ◽  
Inflammatory Diseases ◽  
Kidney Injury ◽  
Tubular Cell ◽  
Protective Effects ◽  
Beneficial Effects ◽  
P53 Signaling

Inflammation and oxidative stress plays an essential role in the pathophysiology of sepsis-associated acute kidney injury (AKI). SPA0355, a thiourea analogue, has been shown to display beneficial effects against a variety of inflammatory diseases arising from its anti-inflammatory and anti-oxidant properties. However, the potential protective effects of SPA0355 against lipopolysaccharide (LPS)-induced AKI have not been explored. The aim of this study was to evaluate the effects of SPA0355 on LPS-induced AKI and investigate its underlying mechanisms. We found that renal dysfunction and histological abnormalities after LPS injection were significantly ameliorated by SPA0355. The compound also reduced renal expression of tubular injury markers. Mechanistically, SPA0355 significantly suppressed plasma and tissue levels of inflammatory cytokines and immune cell infiltration with inhibition of nuclear factor kappa-B p65 signaling. In addition, elevated levels of 4-hydroxynonenal and malondialdehyde after LPS injection were significantly decreased by SPA0355. The compound also regulated expression of pro-oxidant and antioxidant enzymes after LPS injection. Moreover, SPA0355 attenuated LPS-induced tubular cell apoptosis via inhibition of p53 signaling pathway. Altogether, these results suggest that SPA0355 protects against LPS-induced AKI through suppressing inflammation, oxidative stress, and tubular cell apoptosis and might be a potential preventive option for the disease.

scholarly journals Cocoa Polyphenols and Their Potential Benefits for Human Health

2012 ◽  
Vol 2012 ◽  
pp. 1-23 ◽  
Author(s):  
I. Andújar ◽  
M. C. Recio ◽  
R. M. Giner ◽  
J. L. Ríos
Keyword(s):  
Oxidative Stress ◽  
Human Health ◽  
Metabolic Disorders ◽  
Ldl Cholesterol ◽  
Intestinal Inflammation ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Neutrophil Infiltration ◽  
Beneficial Effects ◽  
Potential Benefits

This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid peroxidation and the protection of LDL-cholesterol against oxidation, and increase resistance to oxidative stress. The phenolics from cocoa also modify the glycemic response and the lipid profile, decreasing platelet function and inflammation along with diastolic and systolic arterial pressures, which, taken together, may reduce the risk of cardiovascular mortality. Cocoa polyphenols can also modulate intestinal inflammation through the reduction of neutrophil infiltration and expression of different transcription factors, which leads to decreases in the production of proinflammatory enzymes and cytokines. The phenolics from cocoa may thus protect against diseases in which oxidative stress is implicated as a causal or contributing factor, such as cancer. They also have antiproliferative, antimutagenic, and chemoprotective effects, in addition to their anticariogenic effects.

scholarly journals Bioactive Metabolites Produced by Cyanobacteria for Growth Adaptation and their Pharmacological Properties

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1061
Author(s):  
Pavitra Nandagopal ◽  
Anthony Nyangson Steven ◽  
Liong-Wai Chan ◽  
Zaidah Rahmat ◽  
Haryati Jamaluddin ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Intracellular Signaling ◽  
Bioactive Metabolites ◽  
Atmospheric Nitrogen ◽  
Extrinsic Factors ◽  
Photosynthetic Organisms ◽  
Cyanobacterial Species ◽  
Growth Adaptation ◽  
Intracellular Signaling Molecules ◽  
Adaptation Ability

Cyanobacteria are the most abundant oxygenic photosynthetic organisms inhabiting various ecosystems on earth. As with all other photosynthetic organisms, cyanobacteria release oxygen as a byproduct during photosynthesis. In fact, some cyanobacterial species are involved in the global nitrogen cycles by fixing atmospheric nitrogen. Environmental factors influence the dynamic, physiological characteristics, and metabolic profiles of cyanobacteria, which results in their great adaptation ability to survive in diverse ecosystems. The evolution of these primitive bacteria resulted from the unique settings of photosynthetic machineries and the production of bioactive compounds. Specifically, bioactive compounds play roles as regulators to provide protection against extrinsic factors and act as intracellular signaling molecules to promote colonization. In addition to the roles of bioactive metabolites as indole alkaloids, terpenoids, mycosporine-like amino acids, non-ribosomal peptides, polyketides, ribosomal peptides, phenolic acid, flavonoids, vitamins, and antimetabolites for cyanobacterial survival in numerous habitats, which is the focus of this review, the bioactivities of these compounds for the treatment of various diseases are also discussed.

scholarly journals Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1348
Author(s):  
Sheikh Rashel Ahmed ◽  
Muhammad Fazle Rabbee ◽  
Anindita Roy ◽  
Rocky Chowdhury ◽  
Anik Banik ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Inflammatory Diseases ◽  
Gastric Ulcers ◽  
Active Components ◽  
Synthetic Drugs ◽  
Bowel Diseases ◽  
Anti Inflammatory ◽  
Irritable Bowel ◽  
Biological Entities

When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

scholarly journals Oxidative Stress and Atopic Dermatitis

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 196 ◽  
Author(s):  
Lucrezia Bertino ◽  
Fabrizio Guarneri ◽  
Serafinella Patrizia Cannavò ◽  
Marco Casciaro ◽  
Giovanni Pioggia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Inflammatory Diseases ◽  
Inflammatory Skin Disease ◽  
Environmental Aspects ◽  
Pathogenetic Role ◽  
Chronic Inflammatory Diseases ◽  
Therapeutic Implications ◽  
Different Tissues

Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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