scholarly journals Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

2010 ◽  
Vol 6 ◽  
pp. 966-972 ◽  
Author(s):  
Yang Li ◽  
Wentao Gao
Keyword(s):  
Elemental Analysis ◽  
Condensation Reaction ◽  
Sodium Ethoxide ◽  
Efficient Synthesis ◽  
H Nmr

A simple and efficient synthesis of novel 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles, utilizing sodium ethoxide as a catalyst via a Friedländer condensation reaction between 3-acetyl-9-ethyl-9H-carbazole or 3,6-diacetyl-9-ethyl-9H-carbazole and β-aminoaldehydes or β-aminoketones is described. All of the title compounds were obtained in good yields of 52–72% and their structures were confirmed by IR, 1H NMR, MS, and elemental analysis.

An efficient synthesis of 3-alkyl-2-diversity-substituted benzofuro[3,2-d]pyrimidin-4(3H)-one derivatives

2019 ◽  
Vol 43 (5-6) ◽  
pp. 201-204 ◽  
Author(s):  
Hong-Mei Wang ◽  
Tian-Shuai Wang ◽  
Sheng-Jie He ◽  
Zong-Yun Chen ◽  
Yang-Gen Hu
Keyword(s):  
Mass Spectrometry ◽  
Sodium Ethoxide ◽  
Catalytic Amount ◽  
Alkyl Halides ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
Excess Carbon ◽  
H Nmr ◽  
Aliphatic Esters ◽  
C Nmr

Benzofuro[3,2- d]pyrimidine derivatives are prepared using aza-Wittig reactions of iminophosphoranes with n-butyl isocyanate at 40–50 °C to give carbodiimide intermediates, which are reacted with nitrogen-oxygen-containing nucleophiles to give 3-alkyl-2-amino (aryloxy/alkoxy)-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in satisfactory yields in the presence of a catalytic amount of sodium ethoxide or K2CO3. The iminophosphorane also reacts directly with excess carbon disulfide, followed by n-propylamine; further reaction with alkyl halides or halogenated aliphatic esters in the presence of anhydrous K2CO3 produces the corresponding 2-alkylthio-3-n-propyl-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in good yields. Their structures of the products are confirmed by 1H NMR, 13C NMR, mass spectrometry, infrared and elemental analysis.

scholarly journals Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives

2015 ◽  
Vol 51 ◽  
pp. 115-124
Author(s):  
Haresh G. Kathrotiya ◽  
Yogesh T. Naliapara
Keyword(s):  
Aromatic Amine ◽  
Elemental Analysis ◽  
Condensation Reaction ◽  
High Yield ◽  
Experimental Procedure ◽  
H Nmr ◽  
Quinoxaline Derivatives ◽  
Ft Ir ◽  
C Nmr

A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

scholarly journals Microwave-Assisted Synthesis of Arylidene Acetophenones

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Sheauly Khatun ◽  
M. Z. H. Khan ◽  
Khodeza Khatun ◽  
M. A. Sattar
Keyword(s):  
Microwave Irradiation ◽  
Microwave Heating ◽  
Spectral Data ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Efficient Synthesis ◽  
H Nmr ◽  
Microwave Assisted

An efficient synthesis of arylidene acetophenones have been achieved by using the microwave heating in comparison to the conventional heating. In this work compound 1-phenyle-3-(4-droxyphenyle)-2-propen-1-one, 1-(4-chlorophenyle)-3-phenyle-2-propen-1-one, and 1-(4-chlorophenyle)-3-(4-hydroxyphenyle)-2-propen-1-one have been synthesized by the condensation reaction between aromatic aldehydes and substituted acetophenones under microwave irradiation. The compounds of aldehydes and acetophenones were used as benzaldehyde, parahydroxybenzaldehyde, acetophenone, and parachloroacetophenone. The result shows that the time taken for the reaction was reduced from the conventional 1-2 hours to 60–120 seconds. The yield of the compounds in the conventional heating was moderate while the highest yield of 90–98% was observed in MWI method. The structure of the compounds was characterized by their IR,1H-NMR spectral data.

Synthesis and fungicidal activity of dehydroabietyl-1,2,4-triazolo-thiazolidinones

Holzforschung ◽  
2013 ◽  
Vol 67 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Xue-Tang Xu ◽  
Xian-Li Ma ◽  
Wen-Gui Duan ◽  
Li Chen ◽  
Bo Cen ◽  
...  
Keyword(s):  
Fusarium Graminearum ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Condensation Reaction ◽  
Alternaria Solani ◽  
Aromatic Aldehydes ◽  
Dehydroabietic Acid ◽  
Cercospora Arachidicola ◽  
H Nmr ◽  
C Nmr

Abstract In search of novel potent bioactive compounds, a series of novel dehydroabietic acid derivatives bearing 1,2,4-triazolo-thiazolidinone moieties were designed and synthesized. Seven compounds were synthesized of the type 6-substituted benzylidene-3-dehydroabietyl-thiazolo[2,3-c][1,2,4]triazol-5-ones. To this purpose a condensation reaction was performed with 3-dehydroabietyl-thiazolo[2,3-c][1,2,4]triazol-5-one and various aromatic aldehydes. All the title compounds were analyzed and characterized by means of IR, MS, 1H NMR, 13C NMR, and elemental analysis. A preliminary bioassay showed that, at a concentration of 50 μg ml-1, the target compounds exhibited the best fungicidal activity against Fusarium graminearum (F. graminearum) of the five fungi tested (F. oxysporum f. cucumerinum, Alternaria solani, Physalospora piricola, Cercospora arachidicola, and F. graminearum).

scholarly journals Synthesis of some New Quinoxalines Bearing Pyridinyl Thiazole Moiety

2015 ◽  
Vol 52 ◽  
pp. 74-83
Author(s):  
Haresh G. Kathrotiya ◽  
Yogesh T. Naliapara
Keyword(s):  
Elemental Analysis ◽  
Condensation Reaction ◽  
Mass Spectral Data ◽  
Structural Class ◽  
Mass Spectral ◽  
H Nmr ◽  
Chemical Structures ◽  
Quinoxaline Derivatives ◽  
Ft Ir ◽  
C Nmr

Keeping the objective to build up a new structural class of quinoxaline, a new series of quinoxaline derivatives bearing the pyridinyl thiazole nucleus have been synthesized by base-catalyzed chloro-amine condensation reaction approach. The protocol offers expeditious and easy synthesis with excellent yield. The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.

Synthesis and optical properties of tetrapyrazino-porphyrazines containing camphorquinone group

2009 ◽  
Vol 13 (07) ◽  
pp. 794-797 ◽  
Author(s):  
Chun Keun Jang ◽  
Seung Hwan Byun ◽  
Song Hak Kim ◽  
Do Kyung Lee ◽  
Jae Yun Jaung
Keyword(s):  
Optical Properties ◽  
Nmr Spectroscopy ◽  
Fluorescence Spectroscopy ◽  
Elemental Analysis ◽  
Infrared Radiation ◽  
Condensation Reaction ◽  
Visible Spectroscopy ◽  
H Nmr ◽  
Uv Visible ◽  
Tof Ms

2,3-dicyanopyrazine and metallophthalocyanines were synthesized with magnesium containing (±)camphorquinone substituent. 2,3-dicyanopyrazine was prepared by condensation reaction of diaminomaleonitrile (DAMN) with 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione (1). The tetrapyrazinoporphyrazine was characterized by a combination of UV-visible spectroscopy, fluorescence spectroscopy, infrared radiation, elemental analysis, MALDI-TOF-MS and 1H NMR spectroscopy.

scholarly journals Design and Synthesis of Crown Ether Functionalized Imidazoles as a New type of Building Blocks

2012 ◽  
Vol 9 (4) ◽  
pp. 2128-2133
Author(s):  
Sheng-Hui Li ◽  
Jing Xia
Keyword(s):  
Crown Ether ◽  
Elemental Analysis ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Esi Ms ◽  
Design And Synthesis ◽  
H Nmr ◽  
New Type

A simple, convenient and efficient synthesis for a series of crown ether functionalized imidazoles from benzo-15-crown-5 (B15C5), benzo-18-crown-6 (B18C6), imidazole (Im), 2-methylimidazole (mIm), benzimidazole (bIm) and 2-methyl benzimidazole (mbIm) is reported. All these compounds obtained were characterized by IR,1H NMR, ESI-MS and elemental analysis.

Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides

1995 ◽  
Vol 60 (7) ◽  
pp. 1236-1241 ◽  
Author(s):  
Martin Doležal ◽  
Jiří Hartl ◽  
Antonín Lyčka ◽  
Vladimír Buchta ◽  
Želmíra Odlerová
Keyword(s):  
Nucleophilic Substitution ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Substituted Anilines ◽  
H Nmr

Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides I-X. The structures of compounds were confirmed by elemental analysis, UV, IR and 1H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against M. tuberculosis in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide (I), whose efficacy was the same as that of pyrazinecarboxamide.

scholarly journals Ambient-Temperature Synthesis of (E)-N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine

Molbank ◽  
10.3390/m1250 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1250
Author(s):  
Diana Becerra ◽  
Justo Cobo ◽  
Juan-Carlos Castillo
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Ambient Temperature ◽  
Magnesium Sulfate ◽  
Elemental Analysis ◽  
Condensation Reaction ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Temperature Synthesis ◽  
Tert Butyl

We report the ambient-temperature synthesis of novel (E)-N-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanamine 3 in 81% yield by a condensation reaction between 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and 2-pyridinecarboxaldehyde 2 in methanol using magnesium sulfate as a drying agent. The N-pyrazolyl imine 3 was full characterized by IR, 1D, and 2D NMR spectroscopy, mass spectrometry, and elemental analysis.

scholarly journals Synthesis and antioxidant properties of 2-(3-(hydroxyimino)methyl)-1H-indol-1-yl)acetamide derivatives

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Chandravadivelu Gopi ◽  
Magharla Dasaratha Dhanaraju
Keyword(s):  
Antioxidant Activity ◽  
Condensation Reaction ◽  
Antioxidant Properties ◽  
Side Chain ◽  
Antioxidant Power ◽  
H Nmr ◽  
Antioxidant Agents ◽  
Phenyl Rings ◽  
Ferric Reducing Antioxidant Power ◽  
Ft Ir

Abstract Background The main aim of this work was to synthesise a novel N-(substituted phenyl)-2-(3-(hydroxyimino) methyl)-1H-indol-1-yl) acetamide derivatives and evaluate their antioxidant activity. These compounds were prepared by a condensation reaction between 1H-indole carbaldehyde oxime and 2-chloro acetamide derivatives. The newly synthesised compound structures were characterised by FT-IR, 1H-NMR, mass spectroscopy and elemental analysis. Furthermore, the above-mentioned compounds were screened for antioxidant activity by using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. Result The antioxidant activity result reveals that most of the compounds were exhibiting considerable activity in both methods and the values are very closer to the standards. Among the synthesised compounds, compound 3j, 3a and 3k were shown remarkable activity at low concentration. Conclusion Compounds 3j, 3a and 3k were shown highest activity among the prepared analogues due to the attachment of halogens connected at the appropriate place in the phenyl ring. Hence, these substituted phenyl rings considered as a perfect side chain for the indole nucleus for the development of the new antioxidant agents.

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