<p>Previous coupled climate-ice sheet modeling studies indicate that the warming threshold leading to multi-millennial, large-scale deglaciation of the Greenland Ice Sheet (GrIS) is in the range of 1.6-3.0 K above the pre-industrial climate. These studies either used an intermediate complexity RCM (Robinson et al. 2012) or a low resolution GCM (Gregory et al., 2020) coupled to a zero-order ISM. Here, we investigate the warming threshold and long-term response time of the GrIS using the higher-order Community Ice Sheet Model version 2 (CISM2, Lipscomb et al. 2019), forced with surface mass balance (SMB) calculated with the Community Earth System Model version 2 (CESM2, Danabasoglu et al. 2020). We use different forcing climatologies from a coupled CESM2/CISM2 simulation under high greenhouse gas forcing (Muntjewerf et al. 2020), where each climatology corresponds to a different global warming level in the range of 1-8.5 K above the pre-industrial climate. The SMB, which is calculated in CESM2 using an advanced energy balance scheme at multiple elevation classes (Muntjewerf et al. 2020), is downscaled during runtime to CISM2, thus allowing to account for the surface elevation feedback. In all the simulations the forcing is cycled until the ice sheet is fully deglaciated or has reached a new equilibrium. In a first set of simulations, we find that for a warming level higher than 5.2 K above pre-industrial the ice sheet will disappear, with the timing ranging between 2000 (+8.5 K) and 6000 years (+5.2 K). At a warming level of 2.8 K above pre-industrial, the ice loss does not exceed 2 m SLE, and most of the retreat occurs in the first 10,000 years in the south-west and central-west basins. In contrast, with a higher warming level of 3.6 K above pre-industrial as much as 7 m SLE of ice are loss in 20,000 years, with primary contributions from the western, northern and north-eastern basins. We will conclude by showing preliminary results from a second set of simulations focusing on the 2.8-3.6 K warming above pre-industrial interval.</p>