Peculiar Periprosthetic Fracture Involving Trochanteric Region Along With Shaft of Femur in a 68-Year Male Treated With Locking Plate Fixation and Additional Augmentation with Cable – A Case Report and Review of Literature

Tubercle bacilli has been known to live in symbiosis with mankind since centuries. Tubercle bacilli mainly causes pulmonary disease but extra pulmonary manifestations are fairly common with spine being the most common site

Patterns of Distant Metastases in Patients With Triple-Negative Breast Cancer –– A Population-Based Study

Background Currently, the prognosis of triple-negative breast cancer (TNBC) patients remained poor mainly due to resistance, recurrence, metastasis and severe side effects. The study provided systematic insights into the patterns of TNBC distant metastases (DM), as well as investigating the related elements for the prognosis prediction of TNBC patients on the basis of on large sample. Methods We screened eligible patients with triple-negative breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. Besides, we analyzed differences in baseline characteristics among patients with diverse modes of metastasis. Meanwhile, we calculated proportional mortality ratio (PMR) and the expression of proportional trends in different patients. Subsequently, Kaplan-Meier (KM) analysis was employed to investigate the survival outcomes. Finally, the predictive and prognostic factors of DM were identified. Results In this study, we included 24,822 TNBC patients, including 1,026 DM patients and 23,796 non-DM patients. At the time of initial diagnosis, 4.1% of patients had DM, and 36.9% had multiple metastases. According to the study, the most common sites of metastasis in DM patients were bone (251 cases) and lung (244 cases), while the least common organ of metastasis was brain (37 cases). Age, tumor grade, T, N and marital status were deemed as risk elements of DM. T stage, insurance status, marital status, surgery treatment, chemotherapy, number of metastatic sites and metastatic sites also effect the diagnosis of DM significantly. Conclusion Our study showed that the most common site of metastasis in TNBC patients with DM was bone and the least common site was brain. Different modes of metastasis have different survival and prognostic characteristics. Thus, our research may have important implications for the clinical practice of TNBC patients in the future.

An aggressive fibromatosis in the palm of a female child: A rare case

Aggressive fibromatosis is the locally aggressive benign tumor of mesenchymal origin. It can be found in any part of the body. However, abdomen is the most common site of this lesion. It has a predilection to females between 15 and 60 years. We report the case of a 16-month-old female child with an aggressive fibromatosis in her right palm. The location and age of presentation make this a rare case. She was diagnosed by histopathological examination and the mass was excised. The patient was advised for follow-up examination due to the high degree of recurrence of this tumor.

The clinical study of dermatophytosis in a tertiary care hospital of konkan region, Maharashtra

Dermatophytes are aerobic fungi that produce proteases that digest keratin and allows colonization, invasion and infection of the stratum corneum of the skin, the hair shaft, and the nail. This study was an attempt on the part of the author to find out the incidence and various clinico-epidemiological characteristics of Dermatophytosis in skin OPD of Tertiary care Hospital, B.K.L.W.R.M.C., Dervan. The study was carried on 2444 patients of Dermatophytosis attending the OPD, out of which 49.79% of the cases were Tinea Cruris (TC). The age group of 11-20 years showed maximum prevalence of Dermatophytosis (22.17%). 58% of the patients had diffuse lesions. Body involvement was seen in 87% of cases. Itching was the most common condition associated with Dermatophytosis. 35% of the patients reported with family history of Tinea Cruris.Circumscribed variety of TC was found to be most common variant mostly observed in 2and 4 decade, with a male preponderance. Groin was the most common site with multiple lesions. Nail changes was most commonly associated with TC.

Extranodal Non-Hodgkin Lymphoma: A Rare Presentation Involving the Pancreas

Non-Hodgkin lymphoma (NHL) is a cancer of the immune system, and accounts for 90% of all lymphomas. When lymphoma is discovered outside of the immune system, it is considered extranodal lymphoma. Any organ can be the primary site of NHL, with the gastrointestinal tract being the most common site of involvement. This case study explores the sonographic discovery of an uncommon presentation of NHL with an extranodal mass originating from the pancreatic body and tail, and further extending into the splenic hilum.

Metabolite profiling reveals complex relationship between developing xylem metabolism and intra-ring checking in Pinus radiata

Globally, there has been an increasing amount of wood harvested from younger, fast-growing trees derived from plantation forests. As a consequence, producers and industrial consumers of wood products are becoming increasingly concerned with not only growth rates, but specific wood attributes that affect processing efficiencies and final product quality. Intra-ring checking is a problem that down-grades an unacceptably high proportion of radiata pine clearwood. Methods of identifying trees prone to this undesirable behaviour have been relatively destructive and time consuming, and from a breeding perspective, to date, there is no reliable method of predicting which selected progeny will later show a propensity to check. Using 120, 7-year-old Pinus radiata clones sampled from a common site, displaying difference in the propensity to form intra-ring checks, a GC/MS-based global metabolic profiling technique was employed to demonstrate that metabolomics can be used to accurately identify the checking phenotype. Metabolic profiling coupled with statistical tests was then used to develop models with greater than 90% efficiency to predict the intra-ring checking phenotype. Moreover, an inspection of unique metabolites contributing to the models indicated that coniferin, which is often found as a storage compound in rays, is a strong indicator of intra-ring checking, and indeed those genotypes that displayed the propensity to check inherently had a greater number of ray cells per unit area.

A Rare Case of Squamous Cell Carcinoma Presented with Multiple Discharging Sinus Over the Posterior Aspect of Left Thigh

Squamous cell carcinoma is the second most common cutaneous malignancy. The most important etiological factor is chronic exposure to the ultraviolet rays and hence exposed areas of the body are the most common site of squamous cell carcinoma. It is very uncommon for SCC to occur at unexposed areas of the body, and it is usually associated with long standing ulcers, sinus or immunosuppression. Here we are reporting a rare of Squamous Cell carcinoma which developed from multiple discharging sinus over the posterior aspect of left thigh in a 67 year old male.

P-OGC65 Patterns and timing of recurrence following resection of oesophago-gastric adenocarcinoma

Background Recurrence following resection of oesophago-gastric adenocarcinoma (OGA) is frequent and associated with poor outcomes. Predictors of site, timing and mechanisms driving recurrence is poorly defined, which limits the development of anti-metastatic agents. The aim of this study was to investigate the patterns and timing of recurrence following resection of OGA. Methods Retrospective review of a prospectively maintained resection database from the Glasgow Royal Infirmary oesophago-gastric unit of patients undergoing surgery for OGA. Primary outcomes were recurrence and cancer specific death following surgery. Recurrence patterns were defined as liver, lung, peritoneal, locoregional only and other distant groups. The latter is a heterogenous group that do not include any liver, lung, or peritoneal metastases. Results N = 635 patients were identified having undergone surgical resection of OGA. Of these, n = 262 developed confirmed recurrent disease. Liver metastases (n = 86, 33%) were the most common site of recurrence, followed by peritoneal (n = 35, 13%), lung (n = 33, 13%) locoregional only (n = 51, 20%) and other distant sites (n = 57, 22%). Liver recurrence was associated with significantly worse disease specific (19.1 vs 28.2 months, P < 0.001) and recurrence free survival (P = 0.006). There was no association between site of recurrence and known prognostic clinicopathological factors, including anaerobic threshold (P = 0.810), nodal status (P = 0.088), pathological T-stage (P = 0.357), differentiation (P = 0.195), deprivation index (P = 0.996), perineural (P = 0.475) or lymphovascular (P = 0.422) invasion. Conclusions Liver metastases is the most common site of recurrence following surgery for OGA. Prognostic clinical and pathological factors do not determine the site of recurrence, suggesting that molecular features of the primary tumour determine and promotes recurrence patterns. Further study to delineate the molecular and microenvironment factors driving recurrence patterns is urgently required.

Prevalence of Denture-Related Stomatitis in Edentulous Patients at a Tertiary Dental Teaching Hospital

Oral mucosal lesions can be uncomfortable and can result in a poorer oral health related quality of life. This can be seen especially in edentulous patients who are mostly elderly and have comorbid diseases such as Diabetes Mellitus, which can impair their ability to withstand oral infections. In South Africa, one of the most unequal countries in the world, almost 50% of the population is edentulous and this prevalence increases as age increases. The aim of this cross-sectional study was to determine the prevalence of denture-related stomatitis in subjects who presented to a tertiary institution in Cape Town, South Africa for new complete dentures and to determine the risk indicators associated with it. Three hundred and ninety-six folders of participants who received complete dentures during the period 2014–2019 were included in this study. Categorical data was displayed as frequencies and percentages and a multiple adjusted logistic regression was used to determine associations between Candida and certain risk indicators. The prevalence of denture-related stomatitis was 25.76% (n = 102). Almost 75% (n = 225) females and 72.63% (n = 69) males had no denture-related stomatitis. The most common site for candidiasis in this population was the palate and tonsillar area (40.2%, n = 41) and the least common site was the upper ridge (2.94%, n = 3). Candidiasis, in edentulous patients are highly prevalent in this population and more needs to be done to prevent it.

Epidemiological snapshot of carcinoma lung at a tertiary cancer centre of Bihar, India

Background: According to the GLOBOCAN 2020 report, the estimated incidence of lung cancer in India was 72,510 in all ages and both sexes. In incidence, lung cancer ranked fourth overall among the various types of cancer. To study epidemiological profile in terms of clinical presentation, stage, risk factors and factors associated with late stage presentations at a newly established tertiary cancer care hospital BiharMethods: This was a retrospective-prospective analysis of collected data of histopathologically proven lung cancer cases in the Outpatients department (OPD) of Department of Radiotherapy, All India Institute of Medical Sciences (AIIMS), Patna over a period of 2.5 years from March 2018 to October 2020.Results: There were 140 patients, with a median age of 56 years, 59.28% (n=83) were smokers, 37.14% (n=52) used chewing tobacco, 24.28% (n=34) worked on earthen stoves and 15% (n=21) had passive smoking exposure. The male-to-female ratio was 1.64:1. Non-small cell lung carcinoma comprised 87.85% (n=123), stage IV presentation in 76.42% (n=107) cases with the most common site of metastases being bone (35.51%, 38 patients). IHC was performed on 64 patients (45.71%) of total 140 patients of which 51 patients were of adenocarcinoma histology. 35.29% (n=18) were EGFR positive and 28.57% (n=4) tested ALK positive. 4 patients tested for ROS-1 were negative. 32.14% (n=45) cases were treated empirically for Tuberculosis on the finding of chest X-ray only.Conclusions: Majority of the patients were males in advanced stage. Bone is the most common site of metastases. Long empirical treatments lead to late presentations.