Newly Synthesized Micro-Nano Transition Metal Complexes of Hexadecanoic Acid as Anti-Microbial Agents: Synthesis, Characterization, and Biological Investigations

The synthesis of several metal complexes of d-block elements of hexadecanoic acid (palmitic acid) and its antimicrobial activity was reported in this study. UV-Vis and FT-IR spectroscopy studies were used to characterize and confirm the produced metal complexes by the shift in the absorbance and the formation of M-O linkage. The X-ray diffraction method was mainly used to examine the crystallographic faces of the complexes based on the transition metals. Thermal gravimetric investigation revealed that all metal palmitate complexes had high thermal stability in the range of 250-300°C. The metal complexes of hexadecanoic acid were examined for microbicidal activity against diverse bacterial strains and fungal pathogens using the agar well diffusion method. The copper palmitate complex presented excellent antibacterial activity among the other metal complexes. These outcomes suggest of using fatty acid metal complexes as a suitable candidate in several biomedical applications.

A Fighting Stance Against the “Next Big One” Post-SARS-CoV-2/COVID-19 in Contemporaneous Social Imagery and Journalism

Humanity has to first survive the present SARS-CoV-2/COVID-19 pandemic moment, and then it has to learn from it in order to better handle a similar challenge in the near-, medium-, and far-future. This work explores what an 800+ social imageset from Google Images (seeded with the phrase “COVID19 and future”) and a 724-article journalistic articleset around COVID-19 (with mentions of “future”) suggest about how the general public is thinking about the future either living with COVID-19 or post-COVID-19, at the micro (individual), meso (group, organizational), and macro (societal, global) levels. This work considers what a fighting stance against future pathogenic microbial agents may look like in a broad public mindset based on contemporaneous public data, analyzed both manually and partially computationally.

Identification and antimicrobial susceptibility of microbial agents of otitis externa in dogs

In this study, a total of 277 unmedicated dogs with otitis externa were used. Overall, 413 agents were isolated from 277 ear swab samples; 52.7% of the cases were mono-infections (146 cases), and 37.1% of the cases were poly-infections (103 cases). In 10.1% (28) of the cases, neither bacteria nor yeasts were isolated. Coagulase-positive Staphylococcus spp. were the most frequently isolated bacteria and were found in 90 (21.8%) of the samples. Fifty-eight samples, (14%) were positive for Staphylococcus aureus, 51 (12.3%) for Pseudomonas aeruginosa, 27 (6.5%) for Proteus mirabilis, 27 (6.5%) for Malassezia pachydermatis, 21 (5%) for Corynebacterium spp., 21 (5%) for β-haemolytic Streptococcus spp., 15 (3.6%) for Staphylococcus pseudointermedius, 12 (2.9%) for Proteus spp., 12 (2.9%) for Escherichia coli, 9 (2.1%) for Acinetobacter calcoaceticus, 7 (1.6%) for Trichophyton mentagrophytes, 5 (1.2%) for Staphylococcus auricularis, and 46 (11.1%) for different bacteria and yeasts. A total of 14 different bacteria and yeasts were isolated and identified. Kirby-Bauer antibiotic susceptibility testing was carried out for 10 different antibiotics. The bacterial isolates were found to be resistant to amoxicillin-clavulanic acid (45%), gentamycin (28%), ampicillin/cloxacillin (69%), tobramycin (28%), amikacin (23%), enrofloxacin (47%), chloramphenicol (58%), doxycycline (65%), lincomycin/spectinomycin (58%) and polymyxin B (62%). In conclusion, it is important to test the antimicrobial sensitivity of aetiological agents of otitis externa before treatment so as to prevent the development of antibiotic resistance in bacteria and yeasts.

Initial Development of Hymeneae courbaril (Linnaeus.) (FABACEAE) under inoculation of edophytic bacteria from Bacillus and Herbaspirillum genus / Desenvolvimento inicial de Hymeneae courbaril (Linnaeus.) (FABACEAE) sob inoculação de bactérias endofíticas dos gêneros Bacillus e Herbaspirillum

The rise of environmental problems and the need for recovery of degraded areas have caused interest in the knowledge of native Brazilian species. One of the major barriers to replanting native forests is the production of seedlings of species that can fuel reforestation programs. Hymenaea courbaril is a forest species, has great forest and environmental importance and is very suitable for plants in degraded areas, which can be restored by vegetation, recommended for silvipastoral, pasture afforestation and others. One of the major barriers to replanting native forests is the production of seedlings of species that can fuel reforestation programs. One solution is how growth promoting bacteria that are part of the plant's resident population and are not phytopathogenic. These bacteria can be used to treat micropropagated seeds, explants and seedlings incorporated into the plant substrate. Thus, due to the lack of studies with growth-promoting bacteria in tree species, the aim of this work is to evaluate or development of H. courbaril seedlings. Inoculants are inoculated with growth-promoting endophytes using biometric parameters such as plant size. collection, leaf number, plant height, root system length, biomass and dry matter of shoot and root system. In general the bacteria Herbaspirillum sp. the best result was obtained when an inoculation directly in the soil, presenting greater development of biometric characters. For the genus Bacillus sp. seed inoculation provided further development of the plants. This study contributes to future research and recommends the use of microbial agents to promote H. courbaril growth.

INFECTION AS A RISK FACTOR FOR GALLBLADDER CANCERLITERATURE REVIEW.

Gallbladder cancer (GBC) is the 6th most common gastrointestinal malignancy and most common hepatobiliary malignancy representing 85-90% worldwide with an annual incident of 2/1,00,000 and marked 1 geographical and ethnic variability and known for late diagnosis and poor outcome. High rates of gallbladder carcinoma are seen in different parts of the world like South America (Chilli, Bolivia, and 2 Ecuador) as well as in some parts of India (specically in north IndiaUP, Bihar, Delhi, West Bengal, Assam, and Madhya Pradesh, mostly in Gangetic belt), Pakistan, Japan, and Korea. In north India, gallbladder cancer is 10 times more common in comparison to south India. R 3 Kanthan et al . (2015) divides the risk factor for GBC into four broad groups: i)Patient demography, ii) GB abnormalities, iii)patient exposure to a specic chemical, genetic and molecular factors, iv) Infection. This study says that not only gallbladder stones but also infection by some microbial agents like salmonella and helicobacter also having contributory risk factors