Military Economy and Economic Growth: Bidirectional Effects in Transition Economies of Eurasia

Recently, the worrisome rise of military economy in Eurasian transition economies has raised concerns on what is behind this trend and what are its economic consequences. Based on the evidence from 26 Eurasian countries selected into two subgroups “Russia+10” and “15 Central and Eastern European” (CEE) countries over the period from 1991 to 2019, this article focuses on the military economy overview in this region and demonstrates the result of panel data estimations of bidirectional relation between military economy indicators and economic growth. The study shows that in “Russia+10,” military expenditures to GDP and to government spending have a positive effect on growth, and economic growth has a negative influence on these two indicators. Moreover, armed forces to labor forces have a positive bidirectional relation with economic growth in “Russia+10.” For the samples of “15 CEE” and all Eurasian countries, there are not always statistically significant results to offer clear conclusion on bidirectional effects between military expenditures to GDP and to budget expenses and economic growth. Armed forces to labor forces show a positive effect on growth in Eurasia and “15 CEE” countries.

Identifying therapeutic drug targets using bidirectional effect genes

Prioritizing genes for translation to therapeutics for common diseases has been challenging. Here, we propose an approach to identify drug targets with high probability of success by focusing on genes with both gain of function (GoF) and loss of function (LoF) mutations associated with opposing effects on phenotype (Bidirectional Effect Selected Targets, BEST). We find 98 BEST genes for a variety of indications. Drugs targeting those genes are 3.8-fold more likely to be approved than non-BEST genes. We focus on five genes (IGF1R, NPPC, NPR2, FGFR3, and SHOX) with evidence for bidirectional effects on stature. Rare protein-altering variants in those genes result in significantly increased risk for idiopathic short stature (ISS) (OR = 2.75, p = 3.99 × 10−8). Finally, using functional experiments, we demonstrate that adding an exogenous CNP analog (encoded by NPPC) rescues the phenotype, thus validating its potential as a therapeutic treatment for ISS. Our results show the value of looking for bidirectional effects to identify and validate drug targets.

Assessment of BRDF Impact on VIIRS DNB from Observed Top-of-Atmosphere Reflectance over Dome C in Nighttime

The Day–Night Band (DNB) imaging sensor of the Visible Infrared Imaging Radiometer Suite (VIIRS) adds nighttime monitoring capability to the Suomi National Polar-Orbiting Partnership and National Oceanic and Atmospheric Administration 20 weather satellite launched in 2011 and 2017, respectively. Nighttime visible imagery has already found diverse applications, but image quality is often unsatisfactory. In this study, variations in observed top-of-atmosphere (TOA) reflectance were examined in terms of nighttime bidirectional effects. The Antarctica Dome C ground site was selected due to high uniformity. First, variation of reflectance was characterized in terms of viewing zenith angle, lunar zenith angle, and relative lunar azimuth angle, using DNB data from 2012 to 2020 and Miller–Turner 2009 simulations. Variations in reflectance were observed to be strongly anisotropic, suggesting the presence of bidirectional effects. Then, based on this finding, three popular bidirectional reflectance distribution function (BRDF) models were evaluated for effectiveness in correcting for these effects on the nighttime images. The observed radiance of VIIRS DNB was compared with the simulated radiance respectively based on the three BRDF models under the same geometry. Compared with the RossThick-LiSparseReciprocal (RossLi) BRDF model and Hudson model, the Warren model has a higher correlation coefficient (0.9899–0.9945) and a lower root-mean-square-error (0.0383–0.0487). Moreover, the RossLi BRDF model and Hudson model may have similar effects in the description of the nighttime TOA over Dome C. These findings are potentially useful to evaluate the radiometric calibration stability and consistency of nighttime satellite sensors.