This work is devoted to the studies of optimal perturbation and its transient growth characteristics in Spiral Poiseuille flow (SPF). The Poiseuille number [Formula: see text], representing the dimensionless axial pressure gradient, is varied from 0 to 20,000. The results show that for the axisymmetric case, with the increase of axial shear, the peaks of the amplitudes of azimuthal and radial velocities are both shifted towards the inner cylinder, and a second peak appears near the outer cylinder for both velocity components. Viewing the time evolution of azimuthal shear contribution [Formula: see text] and axial shear contribution [Formula: see text] to the kinetic energy growth of the optimal perturbation, while [Formula: see text] is large enough ([Formula: see text], 20,000), the Reynolds stress mechanism in the meridional plane [Formula: see text] is dominant for the transient growth behavior in SPF relative to anti-lift-up mechanism, which is dominant in the absence of axial flow for co-rotating Taylor–Couette flow with wide gap. For the oblique mode with azimuthal wave number [Formula: see text], which becomes the optimal azimuthal mode over a wide range of azimuthal wave number ([Formula: see text]–10) when [Formula: see text] is large enough, the peaks of the amplitudes of azimuthal and radial velocities are both shifted towards the outer cylinder, opposite to the axisymmetric case.