Invalid Modernism contributes to an intersectional moment in disability studies by looking at aesthetics through non-conforming bodies and minds. It also offers an intersectional understanding of modernism by studying the representation of physical and cognitive difference during a period marked by progressive reforms in health, labor, and welfare. Readings of texts by Henry James, Samuel Beckett, Virginia Woolf, William Carlos Williams, James Joyce, Djuna Barnes, Oscar Wilde, F. T. Marinetti, Jean Toomer, an opera by Alexander Zemlinsky, and paintings and constructions of Dadaists and Surrealists are set against historical developments in sexology, medical discourse, and eugenics and anthropometry. Modernist works are well known for challenging formal features of narration and representation, but this challenge has often been enabled by shell-shocked veterans, tubercular heroines, blind soothsayers, invalid aesthetes, and neurasthenic women. Such figures complicate an aesthetics of autonomy by which modernism is often understood. Since its evolution in the eighteenth century modern aesthetics has been seen in terms of judgments based on detached appreciation. What begins as a private sensory response to an object or natural formation results in a disinterested judgment about the value of that response. By looking at modernist aesthetics through a disability optic, Invalid Modernism attempts to restore the missing body to aesthetic discourse through figures marked by medical discourse of the period as “invalid” subjects.