A seven-bend-achromat lattice option for the HALF storage ring

The Hefei Advanced Light Facility (HALF) is a soft X-ray diffraction-limited storage ring being designed with an energy of about 2.2 GeV and an emittance goal of less than 100 pm·rad. The present HALF lattice is a modified hybrid six-bend-achromat (6BA) lattice with a long and a short straight section in each cell. In this paper, a 7BA lattice is designed for HALF as a promising option, which follows the main feature of hybrid 7BA lattice, but to have a compact configuration and lower emittance, all bends in this lattice are combined-function bends and reverse bends. The designed HALF storage ring has a circumference of 388.8 m and 20 identical cells. Two solutions with different betatron tunes are studied for this lattice. One with smaller tunes has better nonlinear dynamics performance allowing for off-axis injection, which has a natural emittance of 67 pm·rad. The other with larger tunes has very small beta functions at the straight section as well as lower natural emittance of 59 pm·rad, which can enhance the brightness of insertion device (ID) radiation. The intra-beam scattering effect and ID radiation properties are also presented in this paper.

Compensating the cell-induced light scattering effect in light-based bioprinting using deep learning

Digital light processing (DLP)-based 3D printing technology has the advantages of speed and precision comparing with other 3D printing technologies like extrusion-based 3D printing. Therefore, it is a promising biomaterial fabrication technique for tissue engineering and regenerative medicine. When printing cell-laden biomaterials, one challenge of DLP-based bioprinting is the light scattering effect of the cells in the bioink, and therefore induce unpredictable effects on the photopolymerization process. In consequence, the DLP-based bioprinting requires extra trial-and-error efforts for parameters optimization for each specific printable structure to compensate the scattering effects induced by cells, which is often difficult and time-consuming for a machine operator. Such trial-and-error style optimization for each different structure is also very wasteful for those expensive biomaterials and cell lines. Here, we use machine learning to learn from a few trial sample printings and automatically provide printer the optimal parameters to compensate the cell-induced scattering effects. We employ a deep learning method with a learning-based data augmentation which only requires a small amount of training data. After learning from the data, the algorithm can automatically generate the printer parameters to compensate the scattering effects. Our method shows strong improvement in the intra-layer printing resolution for bioprinting, which can be further extended to solve the light scattering problems in multilayer 3D bioprinting processes.

Visualization of Forward Light Scatter in Opacified Intraocular Lenses and Straylight Assessment

Background: Qualitative visualization of forward light scatter and quantitative straylight measurement of intraocular lenses (IOLs). Methods: We analyzed two calcified IOL-explants, the Euromaxx ALI313Y (Argonoptics GmbH) and the LS-312 MF30 (Oculentis BV), one IOL with artificially induced glistenings (PC-60AD, Hoya), and one control (CT Asphina 409MP, Carl Zeiss Meditec AG) free of any opacification. Analysis included light microscopy, qualitative light scatter visualization using ray propagation imaging technique, and quantitative straylight measurement using C-Quant (Oculus). Results: More light scattering effect—visible as increased light intensity outside the IOL’s main focus—was evident in all opacified IOLs than the control. The highest straylight levels were observed in the Euromaxx (289.71 deg2/sr), which showed extensive granular deposits throughout its optic, followed by the MF30 (78.58 deg2/sr), which only showed opacification in its center. The glistenings-IOL demonstrated numerous microvacuoles within the optic and had straylight levels of 22.6 deg2/sr, while the control showed the lowest straylight levels (1.7 deg2/sr). Conclusions: Ray propagation imaging technique allowed qualitative assessment of off-axis veils of light that result from increased forward light scattering. Straylight was increased in all opacified lenses compared to the clear control lens. The IOL opacifications are significant sources of glare.