Updates on the versatile quinoline heterocycles as anticancer agents

Quinoline motifs have befallen significant molecules due to their assortment of interest in medicine, chemical synthesis, coordination chemistry, also in the field of applied chemistry. Therefore, various researchers have produced these molecules as objective structures and studied their natal potential. The current chapter endows with concise attention about cancer, anticancer agents, sources (natural) of quinoline, and together with an innovative scope of quinoline-related medicines. Further, the present section gives knowledge concerned with the anticancer activity of synthesized quinolines and their derivatives.

The Ups and Downs of Mechanism Realism: Functions, Levels, and Crosscutting Hierarchies

Mechanism realists assert the existence of mechanisms as objective structures in the world, but their exact metaphysical commitments are unclear. We introduce Local Hierarchy Realism (LHR) as a substantive and plausible form of mechanism realism. The limits of LHR reveal a deep tension between two aspects of mechanists’ explanatory strategy. Functional decomposition identifies locally relevant entities and activities, while these same entities and activities are also embedded in a nested hierarchy of levels. In principle, a functional decomposition may identify entities engaging in causal interactions that crosscut the hierarchical structure of composition relations, violating the mechanist’s injunction against interlevel causation. We argue that this possibility is realized in the example of ephaptic coupling, a subsidiary process of neural computation that crosscuts the hierarchy derived from synaptic transmission. These considerations undermine the plausibility of LHR as a general view, yet LHR has the advantages that (i) its metaphysical implications are precisely stateable; (ii) the structure it identifies is not reducible to mere aggregate causation; and (iii) it clearly satisfies intuitive and informal definitions of mechanism. We conclude by assessing the prospects for a form of mechanism realism weaker than LHR that nevertheless satisfies all three of these requirements.

Perception and experience of daylight – Reflections of an architect

The information contained in light from our surroundings is often taken for granted because of its ubiquity, and the subliminal nature of the way we normally use it. Revealing the richness and depth of our common human experience through the unexpected qualities of light is seen as an artistic opportunity. An architectural training enables the integration of a subjective and qualitative experience, with the ‘objective’ structures that we are surrounded by. The built space can act as a ‘neutral’ reference onto which the complexity of daylight is superimposed. The author, trained as an architect, has been involved for more than 30 years in the design and construction of non-gallery artworks that engage the experience of natural light in public and semi-public spaces. This practitioner reflection discusses the relation of the position of the observer and sources of light, and how the movement of the viewer acts as a catalyst for revealing their situation through six works of various scales that the author worked on in New York; Boston; Abu Dhabi; London; and Berlin.

Los grupos de investigación consolidados en la praxeología de la Comunicación

The praxeological approach serves to discover the dialectical relationships between the objective structures that condition human action (praxis) of, in this case, the scientific research processes, and the structured dispositions that are updated in academic debates. The MapCom Project drew up a cartographic repository of consolidated research groups in Spanish universities with undergraduate and postgraduate degrees in Communication, as well as a census of researchers active in the Spanish university with degrees in Communication, surveyed them, and organized debate sessions in Madrid, Barcelona and Malaga in 2016 on communication research, which were the first university meetings held in this regard in Spain, applying the Phillips 66 technique. The main results detect the limitations faced by the praxeology of research in communication because there is a reciprocal exclusion between "Fostering the strength of research groups" and the "ANECA effect", said exclusion comes from confronting the policy of cooperation between groups with the policy of individualistic competitiveness and choosing between collective convergence in the production of knowledge or the individual fight for getting re-knowledge.

The Problem of Nature in Hegel's Philosophy of Right

The notion of being-at-home-in-otherness is the distinctive way of thinking of freedom that Hegel develops in his social and political thought. When I am at one with myself in social and political structures (institutions, rights and the state) they are not external powers to which I am subjected but are rather constitutive of my self-relation, that is my self-conception is mediated and expanded through those objective structures. How successfully Hegel may achieve being-at-home-in-otherness with regard to these objective structures of right in the Philosophy of Right is arguable. What is at issue in this paper is however to argue that there is a blind spot in the text with regard to nature. In Ethical Life the rational subject's passions and inclinations are brought into the subject such that she is ‘with herself’ in them; with regard to external nature no such reconciliation is achieved or even attempted. In Abstract Right external nature is effectively dominated by and subsumed into the will and it is never something in which one is with oneself. It remains outside the model of freedom that Hegel develops in the Philosophy of Right. There is something troubling about this formulation, since it excludes nature from freedom, but also something accurate, as it reflects the unresolved attitude of moderns to the natural world.

Theories of Social Networks

Theories of social networks offer abstract perspectives of what social networks are and how they are connected to other features of the social world. This chapter gives an overview of three recent perspectives: (1) Theorists of action (Burt, Coleman, Lin, Hedström) regard social networks as objective structures restricting or enabling individual action. Networks become a resource (social capital) that actors strive to maximize. (2) Authors following pragmatism or symbolic interactionism (Emirbayer, Martin, Crossley) consider social networks as patterns of subjective meaning arising out of the interaction between actors. This approach is linked to field theoretical thinking, considering networks as arising out of the mutual orientation in fields. (3) Relational sociologists (White, Tilly, Mische, Padgett, Fuhse) treat social networks as infused with meaning that is processed in communication/transaction/switchings between actors. Relational sociology has been amended to study networks of symbols and the communicative dynamics of social networks.

Mediatization from Within: A Plea for Emic Approaches to Media-Related Social Change

Based on a literature review, this article shows that current mediatization scholarship is characterized by what Pike (1967) refers to as etic accounts. These accounts forward theoretical categories on media-related social change to conclude that our age is characterized by deepened and expanded media reliance. However, such theoretical extrapolation takes place not from, but at the expense of, people’s lived experiences, that is, emic accounts of mediatization in everyday life. This article is an attempt to insert the etic/emic distinction to mediatization research in order to develop more reflexive and composite accounts. Drawing on examples from a representative survey and qualitative interviews conducted over twenty years, the article problematizes etic-oriented conceptions of mediatization. Emic analyses expose how perceptions of media reliance shift over time and thus underscore the need to develop research strategies that simultaneously consider the objective structures of the social (mediatized) world and subjective meaning-making structures.

Shopping dreams: Oneiric imagination, consumption, and identity projects among US young adults

Scholars working in consumer culture studies have long recognized the significance of the imagination in directing consumption. Largely unconsidered in such studies, however, is nighttime dreaming, a state of consciousness in which consumers regularly engage with the meanings, materialities, identity projects, and objective structures associated with consumption. Synthesizing insights from the anthropology of dreaming with emerging models in the neurosciences, we enlarge discussions of the imagination by examining young US women’s dreams about consumption. Contrary to the Freudian notion that dreams are a-historical and limited to intrapsychic concerns, we demonstrate that dreams realistically simulate the routine, cognitive, multisensory, social, and culturally enframed experiences of waking life. Dreamers do more, however, than mechanically rehearse consumption activities—they also often ponder dimensions of consumer culture that trouble them, including inequalities related to social class, gender, and race. In the oblique mode of oneiric subjectivity, they thereby sometimes advance a commentary on the larger cultural arenas in which daytime consumption is performed. Dreaming, we argue, offers a novel lens through which to surface intimate and highly textured aspects of consumer consciousness that are otherwise difficult to scrutinize. Our analysis thus responds to recent calls in consumer studies for expanding the project of probing consumers’ imaginative states and their implicit and emergent moral dispositions.

El terrorismo de Estado en Argentina (1976-1983). Reflexiones en torno a las prácticas de violencia contra las mujeres en los campos de concentración

Este trabajo, propone un acercamiento a una dimensión de las prácticas del terrorismo de Estado en Argentina: la tortura en los campos de concentración. Más específicamente, sobre la tortura que padecieron las mujeres durante su cautiverio. Para ello, analizamos la experiencia de cuatro militantes políticas, secuestradas en la provincia de Entre Ríos. El trabajo repasa tres momentos bien diferenciados, el antes, el durante y el después del terrorismo de Estado. Cada uno de ellos, permite entender cómo se modifican las estructuras objetivas del Estado para exterminar a los grupos reducidos a una otredad negativizada. This paper proposes an approach to a dimension of the practices of State terrorism in Argentina: torture in the concentration camps. More specifically, about the torture suffered by women during their captivity. For this, we analyze the experience of four political activists, kidnapped in the province of Entre Ríos. The text reviews three distinct moments, the before, during and after State terrorism. Each one of them allows, without deflating the magnitude of what happened, understanding how the objective structures of the State are modified to exterminate the reduced groups to a negativized otherness.