cyclic prodrugs
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Developments in the synthesis of new functionalized bisphosphonate drug candidates such as cyclic prodrugs

2016 ◽  
Vol 191 (11-12) ◽  
pp. 1504-1508 ◽  
Author(s):  
V. A. Pavlov ◽  
F. H. Ebetino ◽  
M. W. Lundy ◽  
J. Joly ◽  
R. L. Dobson ◽  
...  
Keyword(s):  
Drug Candidates ◽  
Cyclic Prodrugs

ChemInform Abstract: Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogues with Improved Membrane Permeability.

ChemInform ◽  
2010 ◽  
Vol 30 (30) ◽  
pp. no-no
Author(s):  
Binghe Wang ◽  
Wei Wang ◽  
Gian P. Camenisch ◽  
Jennifer Elmo ◽  
Huijuan Zhang ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Cyclic Prodrugs

ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability

ChemInform ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. no-no
Author(s):  
Binghe Wang ◽  
Daxian Shan ◽  
Wei Wang ◽  
Huijuan Zhang ◽  
Olafur Gudmundsson ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Opioid Peptides ◽  
Cyclic Prodrugs

A comparison of the effects of p-glycoprotein inhibitors on the blood–brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE)

2009 ◽  
Vol 98 (6) ◽  
pp. 2227-2236 ◽  
Author(s):  
Hui Ouyang ◽  
Thomas E. Andersen ◽  
Weiqing Chen ◽  
Rebecca Nofsinger ◽  
Bente Steffansen ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Opioid Peptide ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Cyclic Prodrugs ◽  
Glycoprotein Inhibitors

Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

2009 ◽  
Vol 98 (1) ◽  
pp. 349-361 ◽  
Author(s):  
Hui Ouyang ◽  
Weiqing Chen ◽  
Thomas E. Andersen ◽  
Bente Steffansen ◽  
Ronald T. Borchardt ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Metabolic Enzymes ◽  
Opioid Peptide ◽  
Intestinal Cell ◽  
Cyclic Prodrugs

Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa

2009 ◽  
Vol 98 (1) ◽  
pp. 337-348 ◽  
Author(s):  
Thomas E. Andersen ◽  
Bente Steffansen ◽  
Ronald T. Borchardt ◽  
Hui Ouyang ◽  
Weiqing Chen
Keyword(s):  
Intestinal Mucosa ◽  
Opioid Peptide ◽  
Intestinal Cell ◽  
Efflux Transporters ◽  
Cyclic Prodrugs

Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides

2006 ◽  
Vol 49 (4) ◽  
pp. 1261-1270 ◽  
Author(s):  
Bianca M. Liederer ◽  
Tarra Fuchs ◽  
David Vander Velde ◽  
Teruna J. Siahaan ◽  
Ronald T. Borchardt
Keyword(s):  
Amino Acid ◽  
Opioid Peptides ◽  
Cyclic Prodrugs
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