Unpacking overtourism as a discursive formation through interdiscursivity

Purpose As tourism destinations grapple with declines in tourist arrivals due to COVID-19 measures, scholarly debate on overtourism remains active, with discussions on solutions that could be enacted to contain the excessive regrowth of tourism and the return of “overtourism”. As social science holds an important role and responsibility to inform the debate on overtourism, this paper aims to understand overtourism by examining it as a discursive formation. Design/methodology/approach The paper explores recurring thematic threads in scholarly overtourism texts, given the phrases coherence as a nodal-point is partially held in place by a collective body of texts authored by a network of scholars who have invested in it. The paper uses interdiscursivity as an interpretative framework to identify overlapping thematic trajectories found in existing discourses. Findings Overtourism, as a discursive formation, determines what can and should be said about the self-evident “truths” of excessive tourist arrivals, the changes tourists bring to destinations and the range of discursive solutions available to manage or end overtourism. As the interpellation of these thematic threads into scholarly texts is based on a sense of crisis and urgency, the authors find that the themes contain rhetoric, arguments and metaphors that problematise tourists and construct them as objects in need of control and correction. Originality/value While the persistence of the discursive formation will be determined by the degree to which scholarly and other actors recognise themselves in it, this paper may enable overtourism scholars to become aware of the limits of their discursive domain and help them to expand the discourse or weave a new one.

The Time of Patriarchs Peter IV and Damian As the Nodal Point of the Genesis of the Coptic Church: Problems and Proposed Solutions

Introduction. The article examines a recently put forward hypothesis that the time of the Coptic Church’s final genesis was the period of the Alexandrian anti-Chalcedonian Patriarchs Peter IV (576–578) and Damian (578–607). Methods. A comparative research method and factor analysis are used. The main research task is to identify all the factors that contributed to the making of full-fledged ecclesiastical structures by the Theodosians (one of the trends of the Egyptian Miaphysites), and a correlation of these factors with each other to single out the main of them. Analysis. The successful establishment of the Miaphysites (Theodosian) episcopate resulted from the configuration of objective and subjective factors. Objective factors include the following: the weakening of control by the central authorities over the structures of the Miaphysites after Justinian I (482/483–565), the increasing regionalization of the empire and the strengthening of the role of local elites in the provinces, the growing importance of the Coptic language in secular and clerical office work. Subjective factors include the victory of the Miaphysite Patriarch Peter IV over his rival Theodore and the appearance of Damian as Peter’s successor. Results. On the whole, the proposed hypothesis quite thoroughly explains the emergence of the Coptic Church during the period. However, it has several disadvantages, which open up a number of prospects for further researches. Firstly, there is almost no explanation for the success of Damian’s personnel policy. Secondly, insufficient attention was paid to the Egyptian anti-Chalcedonian monasticism. From the author’s point of view, Egyptian Miaphysite monks, suffering from the pressure of the central and local authorities after the Chalcedonian schism, managed to establish an effective network functioned as a “rhizome”, on which the episcopate risen during Peter’s and Damian’s time relied primarily in rebuilding stable ecclesiastical structures in Egypt.

Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo

Matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) are regarded as important clinical targets due to their nodal-point role in inflammatory and oncological diseases. Here, we aimed at isolating and characterizing am MMP-2 and-9 inhibitor (MMPI) from Lupinus albus and at assessing its efficacy in vitro and in vivo. The protein was isolated using chromatographic and 2-D electrophoretic procedures and sequenced by using MALDI-TOF TOF and MS/MS analysis. In vitro MMP-2 and 9 inhibitions were determined on colon adenocarcinoma (HT29) cells, as well as by measuring the expression levels of genes related to these enzymes. Inhibitory activities were also confirmed in vivo using a model of experimental TNBS-induced colitis in mice, with oral administrations of 15 mg·kg−1. After chromatographic and electrophoretic isolation, the L. albus MMP-9 inhibitor was found to comprise a large fragment from δ-conglutin and, to a lower extent, small fragments of β-conglutin. In vitro studies showed that the MMPI successfully inhibited MMP-9 activity in a dose-dependent manner in colon cancer cells, with an IC50 of 10 µg·mL−1 without impairing gene expression nor cell growth. In vivo studies showed that the MMPI maintained its bioactivities when administered orally and significantly reduced colitis symptoms, along with a very significant inhibition of MMP-2 and -9 activities. Overall, results reveal a novel type of MMPI in lupine that is edible, proteinaceous in nature and soluble in water, and effective in vivo, suggesting a high potential application as a nutraceutical or a functional food in pathologies related to abnormally high MMP-9 activity in the digestive system.

Vibration control of a linear flexible beam structure excited by multiple harmonics

This paper deals with designing a control force to create nodal point(s) having zero displacement and/or zero slope at selected locations in a vibrating beam structure excited by multiple harmonic forces. It is shown that the steady state vibrations at desired points can be eliminated using applied control forces. The control forces design method is implemented using dynamic Green’s functions that transform the equations of motion from differential to algebraic equations, in which the resulting solution is analytic and exact. The control problem is greatly simplified by utilizing the superposition principle that leads to calculating the control forces to create node(s) for each excitation frequency independently. The calculated control forces can be realized using passive elements such as masses and springs connected to the beam having reaction forces equal to the calculated control forces. The effectiveness of the proposed method is demonstrated on various cases using numerical examples. Through examples, it was shown that creating node(s) with zero deflection, as well as zero slope, not only results in isolated stationary points, but also suppresses the vibrations along a wide region of the beam.

Whose Sidewalk?

Home is a nodal point in a series of polarities, including family-community; space-place; inside-outside; private-public; domestic-social. These may not be stable but seem both solidified and undermined as they play out their meaning and practice in and through the home. The “public” is traditionally the state’s domain, while the “private” the citizens’. But where does “private” end and “public” begin? Can a border or boundary be placed between the two? Is such a boundary culture-specific or universal? Is it static or dynamic? Scholars often perceive borders as barriers and bridges, porous and impenetrable, and border studies have shown that urban entities have their own internal and external borders. I argue that such internal urban micro-boundaries can be found in the domain of domestic space, separating the private from the public, and that they are dynamic and constantly negotiated. Not necessarily marked, they are acknowledged by a mutual and tacit agreement, a social and cultural consensus. In this paper, I focus on common expansions of private into public space in Limassol, Cyprus, and the ways in which, this social consensus is achieved through the use of several tactics. As I illustrate, all these tactics seem to transform public space into private, on a symbolic level. The paper’s contribution lies in the examination of this type of boundary, which has received little academic attention, as well as in the introduction of the term “tactics of inhibition.”

Maß (Moderation, Measure)

This entry on Maß (moderation, measure) explores a concept that has not received much attention in Goethe scholarship and makes a case for its usefulness and versatility in tracking how Goethe addresses a philosophical issue with a history stretching at least back to Aristotle’s conception of “the golden mean.” It shows how Goethe’s writings respond to numerous issues connected with the concept of moderation, ranging from the problem of self-moderation, when an individual’s own internal calibration comes in conflict with societal norms, to the more theoretical question of how to define the correct standard of measure (Maßstab). The discussion of moderation in Goethe’s work is, to be sure, coupled with its opposite, namely the potentially deadly threat of immoderation and excess, such as one finds in Die Leiden des jungen Werthers (1774; The Sorrows of Young Werther), Wilhelm Meisters Lehrjahre (1795; Wilhelm Meister’s Apprenticeship), and Torquato Tasso (1790). Such potential conflicts, which also raise questions of where to position the standard of measure (Maßstab) of behavior, lead naturally into contexts of scientific experimentation, as in Goethe’s essay “Der Versuch als Vermittler von Objekt und Subjekt” (1792; The Experiment as Mediator of Object and Subject), where such standards take on a different valence from their role in mathematically based natural sciences. In addition, Goethe’s novel, Die Wahlverwandtschaften (1809; Elective Affinities), provides a poetic model where conflicts between individually and socially calibrated notions of measure and moderation play out with major ethical consequences. The entry concludes with a reflection on different kinds of aesthetic experience, each with its particular understanding of Maß: the individual’s appreciation of the sublime, the theatrical performance, and the embodiment of the self through poetic meter. Throughout these examples, the entry will underscore the role of narrative constraints: regardless of whether the medium is prose or poetry, one finds that questions of Maß as moderation in Goethe’s writings are often accompanied by questions of narrative control and excess. The following overview and analysis of Maß in Goethe’s writing will show that this term is a nodal point of ethical, epistemological, and aesthetic concerns.

Topological Magnets: Functions Based on Berry Phase and Multipoles

Macroscopic responses of magnets are often governed by magnetization and, thus, have been restricted to ferromagnets. However, such responses are strikingly large in the newly developed topological magnets, breaking the conventional scaling with magnetization. Taking the recently discovered antiferromagnetic (AF) Weyl semimetals as a prime example, we highlight the two central ingredients driving the significant macroscopic responses: the Berry curvature enhanced because of nontrivial band topology in momentum space, and the cluster magnetic multipoles in real space. The combination of large Berry curvature and multipole enables large macroscopic responses such as the anomalous Hall and Nernst effects, the magneto-optical effect, and the novel magnetic spin Hall effect in antiferromagnets with negligible net magnetization, but also allows us to manipulate these effects by electrical means. Furthermore, nodal-point and nodal-line semimetallic states in ferromagnets may provide the strongly enhanced Berry curvature near the Fermi energy, leading to large responses beyond the conventional magnetization scaling. These significant properties and functions of the topological magnets lay the foundation for future technological development such as spintronics and thermoelectric technology. Expected final online publication date for the Annual Review of Condensed Matter Physics, Volume 13 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis

STING is a nodal point for cellular innate immune response to microbial infections, autoimmunity and cancer; it triggers the synthesis of the antiviral proteins, type I interferons. Many DNA viruses, including Herpes Simplex Virus 1 (HSV1), trigger STING signaling causing inhibition of virus replication. Here, we report that HSV1 evades this antiviral immune response by inducing a cellular microRNA, miR-24, which binds to the 3’ untranslated region of STING mRNA and inhibits its translation. Expression of the gene encoding miR-24 is induced by the transcription factor AP1 and activated by MAP kinases in HSV1-infected cells. Introduction of exogenous miR-24 or prior activation of MAPKs, causes further enhancement of HSV1 replication in STING-expressing cells. Conversely, transfection of antimiR-24 inhibits virus replication in those cells. HSV1 infection of mice causes neuropathy and death; using two routes of infection, we demonstrated that intracranial injection of antimiR-24 alleviates both morbidity and mortality of the infected mice. Our studies reveal a new immune evasion strategy adopted by HSV1 through the regulation of STING and demonstrates that it can be exploited to enhance STING’s antiviral action.

African Witchcraft and Religion among the Yoruba: Translation as Demarcation Practice within a Global Religious History

For years, self-identified witches have demanded the public acknowledgement of witchcraft as “religion” in Nigeria. These political debates are reflected in a long-ongoing scholarly discussion about whether “witchcraft” in Africa should be regarded as religion or not. At its core, this discussion concerns the quest for African meanings. I argue that we should focus on the translingual practice as the reason for today’s perception of “African” and “European” differences as incommensurable. Tracing back today’s understanding of witchcraft among the Yoruba (àjé), the Alatinga anti-witchcraft movement of the early 1950s becomes the nodal point of Yoruba witchcraft history. Discussing the Alatinga as translingual practice, I understand Yoruba witchcraft concepts as products of a global religious history. Only in the aftermath of the Alatinga, a hybrid movement, did the need arise to demarcate “African” and “European” meanings. Thus, Yoruba translingual practice has also affected European understandings of religion and witchcraft today.