Rhino-orbital Mucormycosis in a COVID-19 Patient: The First Case in Malaysia

Mucormycosis is an aggressive and potentially fatal fungal infection caused by fungi of the order Mucorales. There has been an increase in the number of cases of rhino-orbital mucormycosis in people with COVID-19, particularly in India. Rhino-orbital-cerebral mucormycosis is the most common manifestation of mucormycosis associated with COVID-19. We report the first case of rhino-orbital mucormycosis in a diabetic patient with SARS-CoV-2 infection in Malaysia. The diagnosis of mucormycosis was confirmed by histopathological examination, but the fungal culture and PCR results were negative. He was treated with antifungal therapy and had extensive debridement. Treatment of mucormycosis requires a multidisciplinary approach that includes addressing underlying risk factors, effective antifungal therapy, and surgical debridement.

An Unusual Presentation of Cutaneous Alternariosis with Bullous Lesions in A Patient with Diabetes Mellitus

Diabetes mellitus considered to represent an immunodeficient state significantly predisposes patients to all types of opportunistic invasive fungal infection. However, very few cases of cutaneous alternariosis associated with diabetes have been reported previously. Herein, we describe a rare case of cutaneous alternariosis in an elderly diabetic patient with antecedent local trauma.

Autoregression of Neovascularization of the Disc (NVD) and Neovascularization Elsewhere in the Retina (NVE) in Type I Diabetic Patient

Spontaneous resolution of NVD or NVE is very rare, to the best of our knowledge, only five cases reported in the literatures. In this paper we reported a case of spontaneous regression of NVD and NVE in fundus of type one young diabetic female patient with history of bariatric surgery 1 year prior to presentation. Patient was followed up for 2 years with stable clinical course and without developing any further DR and without receiving any treatment. we assumed that this autoregression of neovascularization could be related to her blood sugar control secondary to bariatric surgery. We noticed also all the previous reported five cases were young ages (31, 46, 27,26 and 19). This suggest the possibility of difference in the pathogenesis of proliferative retinopathy between type 1 and type II. Further studies are needed.

Bone Markers (BMKs) and its Relation with Peripheral Neuropathy (PNP) in Type 2 Diabetic Patient (T2DM) in Basrah

The aim of this study was to evaluate differences in bone metabolism by calculating markers of bone turnover (C-terminal telopeptide and osteocalcin) with type 2 diabetes and patients in diabetic peripheral neuropathy patients compared with those without diabetic peripheral neuropathy.

Diabetes Mellitus: Worst Comorbidity to have in COVID-19 Pandemic

Background: Diabetic patients have shown the worst clinical manifestation of the COVID-19. They are at higher risk of being infected and producing severe clinical outcomes, challenging to manage. Also, the share of the diabetic patient among case fatalities is large. Summary: COVID-19 is a disease pandemic that has spread worldwide. All sections and age groups of people worldwide have been affected by the pandemic. Diabetes mellitus is the worst disease to have in OVID-19, as studies have shown some adverse clinical outcome that needs sophisticated medical attention. In lack of resources and overwhelmed infrastructure, the availability of these is tricky. Conclusion: More study is needed about the bidirectional relationship between COVID-19 and diabetes mellitus so that a clearer picture can be emerged out of the fogged situation. Diabetes is already grappling the world, which is suggested by increasing the number of diabetic patient’s number worldwide. Especially in COVID-19, it has become a challenge to contain the disease along with all these comorbidities. The immunosuppressive state brought about by various underlying medical conditions like diabetes mellitus is suitable ground for novel coronavirus to propagate itself.

Mucormycosis of the external and middle ear complicated by parotid abscess and facial paralysis: A very rare case report

Mucormycosis is a serious and relatively rare invasive fungal infection. The rhino-orbito-cerebral localization is the most frequent. Mucormycosis of external ear with facial palsy is extremely rare. We describe a case of mucormycosis of the external ear complicated by parotid abscess and facial palsy in a diabetic patient.