As a natural phenomenon, thunder and lightning have a major impact on human production and life. As an important part of lightning protection technology, the main task of the lightning mobile positioning system is to detect and determine the location of lightning and, at the same time, provide more accurate lightning discharge parameters for lightning research. It is a new technology that serves the entire society and is in urgent need of development. This paper aims to study the trend prediction of thunderstorm cloud based on the monitoring data of the thunder and lightning mobile positioning system. In this thesis, the inverse distance-weighted interpolation method can be used to determine the lightning area and the principle of lightning monitoring and positioning, and the classification of lightning and the practical significance of lightning mobile positioning system monitoring are also studied. Finally, the Hurst index of this paper can reveal the trend elements in the time series well through the experiment, so as to judge the lightning strikes. At the same time, it also introduces everyone’s satisfaction survey on the lightning mobile positioning system. The results of this paper show that the lightning mobile positioning system has been widely used in our country’s meteorological monitoring stations, and it plays a very important role in our national defense lightning strikes and effectively realizes the lightning strike prediction in the monitoring process, which can better enable the competent department to take timely and accurate measures to prevent lightning strikes. Experimental analysis shows that the accuracy of the lightning mobile positioning system has reached 92%, and the practicability has reached 88%.