EUTHANASIA - A CHOICE BETWEEN DEATH AND DEATH (THE VIEW OF EUROPE AND RUSSIA)

В современном научном дискурсе появляется много интересных тем, рассматривающих самые острые проблемы социума, и одна из них - табуированная тема - эвтаназия. Эта проблема носит междисциплинарный характер. Философы, в рамках биоэтики, осмысливают нравственные аспекты, психологи «решают» дилемму «хорошо/плохо», «убийство/самоубийство/гуманный акт помощи», юристы прорабатывают нормативно-правовые акты по защите, зачастую трудносовместимых, прав пациентов/врачей/выгодополучателей, медики, сталкиваясь с «невыносимой физической и психологической болью» пациентов и близких родственников, предлагают свои варианты решения проблемы, физики, химики, генетики не остаются в стороне, развивая нейротехнологии, регенеративную медицину, фармакологию, био- и генные технологии. Политики, разворачивая широкие дискуссии о морально-этической стороне этого вопроса, российском традиционализме, либеральных ценностях, устраивая политические дебаты, разрабатывают дивиденды. Социологи, рассматривая эту социальную проблему, замеряют «градус общественного мнения». Общество, как живой сложносоставной организм, опираясь на свои ментальные программы, реагирует по-разному: от полного неприятия («человеческая жизнь - божественный дар») до однозначной легализации процедуры «достойной смерти, качественной смерти». Одна из важных проблем медицинского профессионального сообщества - проблема обеспечения «достойной смерти» неизлечимо больных пациентов и связанная с ней проблема эвтаназии. Мнение полярно. На понимание медиками проблем легализации эвтаназии оказывают влияние разновекторные факторы: во-первых, ценностные установки, во-вторых, опыт и место работы (врачи паллиативных отделений, хосписов, онкологи, имеющие большой стаж работы, более склоны к легализации эвтаназии), в-третьих, техническое, технологическое, фармакологическое обеспечение медицинского учреждения, в-четвертых, нормативно-правовая составляющая. Many interesting topics appear in the modern scientific discourse. They consider the most acute problems of society and one of them is a taboo topic - euthanasia. This problem is of an interdisciplinary nature. Philosophers within the framework of bioethics comprehend the moral aspects. Psychologists "solve" the dilemma of "good/bad", "murder/suicide/humane act of assistance". Lawyers are working on regulatory legal acts to protect the rights of patients/doctors/beneficiaries, which are often difficult to replace. Doctors, facing the "unbearable physical and psychological pain" of patients and close relatives, offer their own solutions to the problem, physicists, chemists, geneticists do not stay away, developing neurotechnologies, regenerative medicine, pharmacology, bio and gene technologies. Politicians also do not stand aside, unfolding broad discussions, arranging political debates, developing dividends. Sociologists considering this social problem measure the "degree of public opinion". Society as a living complex organism relying on its mental programs reacts in different ways: from complete rejection to legalization of this procedure. One of the important problems of the medical professional community is the problem of ensuring a “dignified death” of terminally ill patients and the related problem of euthanasia. The opinion of doctors is polar. Doctor`s understanding of the problems of legalizing euthanasia is influenced by various factors: firstly, values, secondly, experience and place of work (doctors of palliative departments, hospices, oncologists with long work experience are more inclined to legalize euthanasia), thirdly, technical, technological, pharmacological support of a medical institution, and fourthly, the regulatory component

INTERACTOMICS AND PERSONALIZED PHARMACOTHERAPY - PRESENT AND LOOKING INTO THE FUTURE

The review highlights the advances in natural science that form the basis of the concept of personalized and precision medicine (PPM). The provisions of PPM (prediction, prevention, personalization) are disclosed and modern molecular genetic tools are shown, which are used in leading scientific and practical biomedical centers to improve the quality of treatment of patients with multifactorial diseases (MFD). The main principles of molecular genetic biomarking of MFDs, as well as gene technologies (CRISPR, non-coding RNA, etc.) used in medical practice and at the stage of clinical trials are highlighted. Particular attention is paid to molecular genetic methods of targeted therapy for cancer, including antitumor vaccines. Scientific developments in the field of prediction and preventive treatment of MFD are considered - precision healing technologies of tomorrow. The main provisions of interactomics as an interdisciplinary field of natural science are highlighted, as well as the applied aspects of this section of fundamental science for the creation of diagnostic and treatment-and-prophylactic technologies of a new generation.

Public Consultation on Proposed Revisions to Norway’s Gene Technology Act: An Analysis of the Consultation Framing, Stakeholder Concerns and the Integration of Non-Safety Considerations

In Norway, genetically modified organisms (GMOs) are regulated through the Gene Technology Act of 1993, which has received international attention for its inclusion of non-safety considerations. In 2017, the Norwegian Biotechnology Advisory Board triggered a process to revise the Act that included a public consultation and resulted in the “Proposal for relaxation.” Using poststructuralist discourse analysis, we critically analyze the premises and processes through which the proposal for relaxation was developed—including the public consultation—to understand the range of stakeholder concerns and how these concerns shaped the final proposal. We find that the proposal does not include all concerns equally. The Norwegian Biotechnology Advisory Board’s privileging of technological matters and its preference for tier-based regulation skewed the proposal in a way that reduced broader societal concerns to technological definitions and marginalized discussion of the social, cultural, and ethical issues raised by new gene technologies. To prevent such narrowing of stakeholder concerns in the future, we propose Latour’s model for political economy as a tool to gauge the openness of consultations for biotechnology regulation.

Biotechnology.

Biotechnology is the fusion of biology and technology. It changes and improves the characteristics of an organism at a cellular and molecular level for the benefit of mankind. Unlike conventional plant breeding methods, biotechnological techniques operate at tissue, cell, protoplast and molecular level for the genetic modification and subsequent screening for superior genotypes (Gosal et al., 2010). Biotechnology in a broad sense has been practiced for centuries for curd making, food preservation, pickle making and fermentation. However, biotechnology got a boost during the 1970s with the discovery of restriction enzymes, which led to the development of a variety of gene technologies; it is thus considered to be the greatest scientific revolution of the 20th century.

3D Visualizations of Multiple Coronaviruses on Whole Genomes

COVID-19 triggered by SARS-CoV-2 has become a common problem faced by people all over the world. With the development of bioinformatics and the breakthrough progress of gene technologies. It is a challenging topic to use genomic datasets for SARS-CoV-2 research. In this paper, a 3D visualization method is pro-posed to show the A9 module of the metagenomic analysis system MAS. Seven coronaviruses of genera were illustrated and briefly analyzed. Comparing the visualization results, various SARS-CoV-2 genomes were represented as 2D and 3D maps under different conditions. Through related specific projections, the characteristics of the coronavirus can be observed intuitively from the projection results to provide an effective viewpoint for studying viral genomes.

The use of gene technologies in the genomic-index assessment of producers of Canadian breeding

The article provides an assessment of the use of gene technologies in the genomic-index assessment of producers in the conditions of farms in the Moscow region, which allows to provide dairy farming with high-quality breeding material. Genomic index assessment accelerates the breeding goal achievement process. It contributed to an increase in the productivity of cattle, an increase in the profitability of cattle breeding, which allows to reduce the time for creating breeding herds of dairy cattle by 2 times. Of the 15 bulls, 10 (67%) were evaluated by the A1-A3 breeding categories. Two bulls were categorized as neutral. The bull Ecuador received the A2B1 breeding categories. The daughters of this bull are fat and milk enhancers, which is 4.46%, with a milk yield of 12432 kg of milk.

The Use of Genetic and Gene Technologies in Shaping Modern Rapeseed Cultivars (Brassica napus L.)

Since their domestication, Brassica oilseed species have undergone progressive transformation allied with the development of breeding and molecular technologies. The canola (Brassica napus) crop has rapidly expanded globally in the last 30 years with intensive innovations in canola varieties, providing for a wider range of markets apart from the food industry. The breeding efforts of B. napus, the main source of canola oil and canola meal, have been mainly focused on improving seed yield, oil quality, and meal quality along with disease resistance, abiotic stress tolerance, and herbicide resistance. The revolution in genetics and gene technologies, including genetic mapping, molecular markers, genomic tools, and gene technology, especially gene editing tools, has allowed an understanding of the complex genetic makeup and gene functions in the major bioprocesses of the Brassicales, especially Brassica oil crops. Here, we provide an overview on the contributions of these technologies in improving the major traits of B. napus and discuss their potential use to accomplish new improvement targets.

3D Visualizations of Multiple Coronaviruses on Whole Genomes

COVID-19 triggered by SARS-CoV-2 has become a common problem faced by people all over the world. With the development of bioinformatics and the breakthrough progress of gene technologies. It is a challenging topic to use genomic datasets for SARS-CoV-2 research. In this paper, a 3D visualization method is proposed to show the A9 module of the metagenomic analysis system MAS. Seven coronaviruses of genera were illustrated and briefly analyzed. Comparing the visualization results, various SARS-CoV-2 genomes were represented as 2D & 3D maps under different conditions. Through related specific projections, the characteristics of the coronavirus can be observed intuitively from the projection results to provide an effective viewpoint for studying viral genomes.

Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Chronic infection with viral hepatitis is a major risk factor for liver injury and hepatocellular carcinoma (HCC). One major contributing factor to the chronicity is the dysfunction of virus-specific T cell immunity. T cells engineered to express virus-specific T cell receptors (TCRs) may be a therapeutic option to improve host antiviral responses and have demonstrated clinical success against virus-associated tumours. This review aims to give an overview of TCRs identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field. TCR isolation pipelines, liver homing signals, cell type options, as well as safety considerations will be discussed herein.